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    Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) [ Mus musculus (house mouse) ]

    Gene ID: 12123, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hrkprovided by MGI
    Official Full Name
    harakiri, BCL2 interacting protein (contains only BH3 domain)provided by MGI
    Primary source
    MGI:MGI:1201608
    See related
    Ensembl:ENSMUSG00000046607 AllianceGenome:MGI:1201608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DP5; Bid3; harakiri
    Summary
    Predicted to be involved in cellular response to potassium ion starvation; positive regulation of cellular component organization; and positive regulation of neuron apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in central nervous system; epidermis; olfactory epithelium; and peripheral nervous system ganglion. Orthologous to human HRK (harakiri, BCL2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 5.4), cortex adult (RPKM 4.2) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hrk in Genome Data Viewer
    Location:
    5 F; 5 58.16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118307829..118327543)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (118169764..118189478)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 8 Neighboring gene STARR-seq mESC enhancer starr_14188 Neighboring gene predicted gene, 26411 Neighboring gene predicted gene, 30522 Neighboring gene ring finger protein, transmembrane 2 Neighboring gene STARR-positive B cell enhancer ABC_E431 Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene predicted gene, 25076

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    activator of apoptosis harakiri
    Names
    BH3 interacting (with BCL2 family) domain, apoptosis agonist
    BH3-interacting domain-containing protein 3
    neuronal death protein DP5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007545.2NP_031571.1  activator of apoptosis harakiri

      See identical proteins and their annotated locations for NP_031571.1

      Status: VALIDATED

      Source sequence(s)
      AC110254, D83698
      Consensus CDS
      CCDS39236.1
      UniProtKB/Swiss-Prot
      P62816, P70678
      Related
      ENSMUSP00000057532.5, ENSMUST00000054836.7
      Conserved Domains (1) summary
      pfam15196
      Location:192
      Harakiri; Activator of apoptosis harakiri

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      118307829..118327543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)