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    Asns asparagine synthetase [ Mus musculus (house mouse) ]

    Gene ID: 27053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asnsprovided by MGI
    Official Full Name
    asparagine synthetaseprovided by MGI
    Primary source
    MGI:MGI:1350929
    See related
    Ensembl:ENSMUSG00000029752 AllianceGenome:MGI:1350929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Predicted to be involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and positive regulation of mitotic cell cycle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 65.1), liver E14.5 (RPKM 53.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asns in Genome Data Viewer
    Location:
    6 A1; 6 3.31 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (7675169..7693209, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (7675165..7693209, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tachykinin 1 Neighboring gene predicted gene, 35051 Neighboring gene SET pseudogene Neighboring gene STARR-seq mESC enhancer starr_15097 Neighboring gene STARR-seq mESC enhancer starr_15099 Neighboring gene STARR-seq mESC enhancer starr_15100 Neighboring gene STARR-seq mESC enhancer starr_15101 Neighboring gene STARR-seq mESC enhancer starr_15102 Neighboring gene RIKEN cDNA 1700012J15 gene Neighboring gene predicted gene, 35194

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression. Clerici S, et al. EMBO Mol Med, 2024 Jun. PMID 38684863, Free PMC Article
    2. Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation. Zhu Y, et al. Circulation, 2024 Jun 4. PMID 38586957,
    3. Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver. Iida S, et al. Biol Pharm Bull, 2013. PMID 24292060
    4. Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression. Grima-Reyes M, et al. Sci Adv, 2022 Jul 8. PMID 35857457, Free PMC Article
    5. Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. Ruzzo EK, et al. Neuron, 2013 Oct 16. PMID 24139043, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression.
      Title: Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression.
    2. Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation.
      Title: Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation.
    3. Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
      Title: Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
    4. Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.
      Title: Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.
    5. Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.
      Title: Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.
    6. Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.
      Title: Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.
    7. Asns is involved in the regulation of plasma glucose levels.
      Title: Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within asparagine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asparagine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to aldosterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to amino acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to follicle-stimulating hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to light stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    asparagine synthetase [glutamine-hydrolyzing]
    Names
    glutamine-dependent asparagine synthetase
    NP_001397534.1
    NP_001397535.1
    NP_001397536.1
    NP_001397537.1
    NP_001397538.1
    NP_036185.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410605.1 → NP_001397534.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

      Status: VALIDATED

      Source sequence(s)
      AC129291
      UniProtKB/Swiss-Prot
      Q3TJA1, Q61024, Q8BPC8
      UniProtKB/TrEMBL
      Q3TV20

    2. NM_001410606.1 → NP_001397535.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

      Status: VALIDATED

      Source sequence(s)
      AC129291
      UniProtKB/Swiss-Prot
      Q3TJA1, Q61024, Q8BPC8
      UniProtKB/TrEMBL
      Q3TV20
      Related
      ENSMUSP00000111204.2, ENSMUST00000115542.8

    3. NM_001410607.1 → NP_001397536.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

      Status: VALIDATED

      Source sequence(s)
      AC129291
      UniProtKB/Swiss-Prot
      Q3TJA1, Q61024, Q8BPC8
      UniProtKB/TrEMBL
      Q3TV20

    4. NM_001410608.1 → NP_001397537.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

      Status: VALIDATED

      Source sequence(s)
      AC129291
      UniProtKB/Swiss-Prot
      Q3TJA1, Q61024, Q8BPC8
      UniProtKB/TrEMBL
      Q3TV20

    5. NM_001410609.1 → NP_001397538.1  asparagine synthetase [glutamine-hydrolyzing] isoform b

      Status: VALIDATED

      Source sequence(s)
      AC129291

    6. NM_012055.5 → NP_036185.1  asparagine synthetase [glutamine-hydrolyzing] isoform a

      See identical proteins and their annotated locations for NP_036185.1

      Status: VALIDATED

      Source sequence(s)
      AC129291
      Consensus CDS
      CCDS19907.1
      UniProtKB/Swiss-Prot
      Q3TJA1, Q61024, Q8BPC8
      UniProtKB/TrEMBL
      Q3TV20
      Related
      ENSMUSP00000031766.6, ENSMUST00000031766.12
      Conserved Domains (1) summary
      PRK09431
      Location:1 → 560
      asnB; asparagine synthetase B; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      7675169..7693209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61024.3 GenPept UniProtKB/Swiss-Prot:Q61024

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