U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gca grancalcin [ Mus musculus (house mouse) ]

    Gene ID: 227960, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gcaprovided by MGI
    Official Full Name
    grancalcinprovided by MGI
    Primary source
    MGI:MGI:1918521
    See related
    Ensembl:ENSMUSG00000026893 AllianceGenome:MGI:1918521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5133401E04Rik
    Summary
    Predicted to enable calcium ion binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be located in cytosol and plasma membrane. Is expressed in cerebral cortex ventricular layer and telencephalon ventricular layer. Orthologous to human GCA (grancalcin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 6.2), frontal lobe adult (RPKM 5.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gca in Genome Data Viewer
    Location:
    2 C1.3; 2 36.47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (62494671..62524453)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62664327..62694109)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene fibroblast activation protein Neighboring gene STARR-seq mESC enhancer starr_04642 Neighboring gene STARR-positive B cell enhancer ABC_E10108 Neighboring gene STARR-positive B cell enhancer ABC_E4458 Neighboring gene STARR-positive B cell enhancer ABC_E1006 Neighboring gene interferon induced with helicase C domain 1 Neighboring gene STARR-seq mESC enhancer starr_04644 Neighboring gene predicted gene, 39839 Neighboring gene STARR-seq mESC enhancer starr_04645 Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 7 Neighboring gene predicted gene, 22020 Neighboring gene predicted gene 13569

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145523.3NP_663498.1  grancalcin

      See identical proteins and their annotated locations for NP_663498.1

      Status: PROVISIONAL

      Source sequence(s)
      AK078915
      Consensus CDS
      CCDS16069.1
      UniProtKB/Swiss-Prot
      Q8BL53, Q8K3Z6, Q8VC88
      Related
      ENSMUSP00000028257.3, ENSMUST00000028257.3
      Conserved Domains (3) summary
      cd00051
      Location:67122
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:128183
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:97152
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      62494671..62524453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)