Dhrs4 dehydrogenase/reductase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dhrs4provided by MGI
Official Full Name: dehydrogenase/reductase 4provided by MGI
Primary source: MGI:MGI:90169
See related: Ensembl:ENSMUSG00000022210 AllianceGenome:MGI:90169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CR; RRD; NDRD; PHCR; PSCD; mouNRDR; D14Ucla2
Summary: Enables retinal dehydrogenase activity. Acts upstream of or within retinal metabolic process. Located in mitochondrion and peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 28.9), liver E18 (RPKM 24.8) and 28 other tissues See more
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55715880..55727797)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55478741..55490340)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An analysis of the relationship between the promoter characteristics and RNA expression of the DHRS4 gene cluster indicated that the development of CpG islands, in addition to the promoter sequence, during mammalian evolution could modulate the dose compensatory regulation of the copy number-varied DHRS4 gene cluster
Title: CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.
M. musculus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. M. musculus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
Title: Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130081 (e-PCR)
- UniSTS:213369

AI043103 (e-PCR)
- UniSTS:160389

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-keto sterol reductase activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables carbonyl reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ketone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinal metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 4

Names: NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; dehydrogenase/reductase (SDR family) member 4; peroxisomal short-chain alcohol dehydrogenase; short chain dehydrogenase/reductase family 25C member 2

NP_001033027.2

EC 1.1.1.184

EC 1.1.1.300

NP_109611.1

EC 1.1.1.184

EC 1.1.1.300

XP_030103712.1

EC 1.1.1.184

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037938.2 → NP_001033027.2 dehydrogenase/reductase SDR family member 4 isoform 1

See identical proteins and their annotated locations for NP_001033027.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC159002, AK146988, BQ032668, BY291911

Consensus CDS

CCDS27111.1

UniProtKB/Swiss-Prot

G3X8V7, Q99LB2, Q9EQU4

UniProtKB/TrEMBL

Q3UIB5

Related

ENSMUSP00000022821.7, ENSMUST00000022821.8

Conserved Domains (2) summary

cd08936
Location:24 → 279

CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR

PRK07231
Location:31 → 274

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
NM_030686.2 → NP_109611.1 dehydrogenase/reductase SDR family member 4 isoform 2

See identical proteins and their annotated locations for NP_109611.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC159002, AK018788, AW125533, BY291911

Consensus CDS

CCDS88668.1

UniProtKB/TrEMBL

Q9D2U3

Related

ENSMUSP00000154481.2, ENSMUST00000226168.2

Conserved Domains (1) summary

cl21454
Location:24 → 178

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

55715880..55727797

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247852.2 → XP_030103712.1 dehydrogenase/reductase SDR family member 4 isoform X1

Conserved Domains (1) summary

cl21454
Location:24 → 137

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins