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    Pxn paxillin [ Mus musculus (house mouse) ]

    Gene ID: 19303, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pxnprovided by MGI
    Official Full Name
    paxillinprovided by MGI
    Primary source
    MGI:MGI:108295
    See related
    Ensembl:ENSMUSG00000029528 AllianceGenome:MGI:108295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pax
    Summary
    Enables BH4 domain binding activity; MAP-kinase scaffold activity; and neuropilin binding activity. Involved in positive regulation of angiogenesis and transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including focal adhesion assembly; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Located in focal adhesion and lamellipodium. Is expressed in several structures, including central nervous system; genitourinary system; immune system; inner ear; and lens. Orthologous to human PXN (paxillin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 49.8), colon adult (RPKM 41.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pxn in Genome Data Viewer
    Location:
    5 F; 5 56.1 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115630035..115694046)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115491970..115555987)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sirtuin 4 Neighboring gene STARR-seq mESC enhancer starr_14130 Neighboring gene predicted gene, 24265 Neighboring gene predicted gene, 24407 Neighboring gene 40S ribosomal protein S5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14131 Neighboring gene predicted gene 13840 Neighboring gene STARR-seq mESC enhancer starr_14132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:115984948-115985057 Neighboring gene STARR-positive B cell enhancer ABC_E1687 Neighboring gene STARR-positive B cell enhancer ABC_E671 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene microRNA 7029

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BH4 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables MAP-kinase scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables neuropilin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor complex adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables vinculin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403066.1NP_001389995.1  paxillin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159539
      UniProtKB/TrEMBL
      A0A1D5RMM8
      Related
      ENSMUSP00000148843.3, ENSMUST00000212819.3
    2. NM_001403067.1NP_001389996.1  paxillin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159539
      UniProtKB/TrEMBL
      Q99LE7
    3. NM_001403068.1NP_001389997.1  paxillin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC159539
      UniProtKB/TrEMBL
      A0A0J9YV30, Q99LE7
    4. NM_001403069.1NP_001389998.1  paxillin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC159539
      UniProtKB/TrEMBL
      A0A0J9YV30, Q99LE7
      Related
      ENSMUSP00000144459.2, ENSMUST00000202564.2
    5. NM_001403070.1NP_001389999.1  paxillin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC159539
      UniProtKB/TrEMBL
      A0A0J9YV30, Q99LE7
    6. NM_011223.4NP_035353.1  paxillin isoform alpha

      See identical proteins and their annotated locations for NP_035353.1

      Status: VALIDATED

      Source sequence(s)
      AC159539
      Consensus CDS
      CCDS19593.1
      UniProtKB/TrEMBL
      Q3UG90
      Related
      ENSMUSP00000069624.9, ENSMUST00000067268.15
      Conserved Domains (5) summary
      cd09407
      Location:383434
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09409
      Location:442494
      LIM3_Paxillin; The third LIM domain of paxillin
      cd09411
      Location:501552
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:324376
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    7. NM_133915.4NP_598676.2  paxillin isoform beta

      See identical proteins and their annotated locations for NP_598676.2

      Status: VALIDATED

      Source sequence(s)
      AC159539
      Consensus CDS
      CCDS39229.1
      UniProtKB/Swiss-Prot
      Q3TB62, Q3TZQ6, Q8VI36, Q8VI37
      UniProtKB/TrEMBL
      F8VQ28
      Related
      ENSMUSP00000083709.4, ENSMUST00000086523.7
      Conserved Domains (5) summary
      cd09338
      Location:476528
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:417468
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:535586
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:358410
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family

    RNA

    1. NR_175347.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159539

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115630035..115694046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254218.2XP_030110078.1  paxillin isoform X7

      UniProtKB/TrEMBL
      Q99LE7
      Conserved Domains (5) summary
      cd09338
      Location:343395
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:402453
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:225277
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      cl02475
      Location:284335
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam03535
      Location:1120
      Paxillin; Paxillin family
    2. XM_036164917.1XP_036020810.1  paxillin isoform X2

      UniProtKB/TrEMBL
      A0A1D5RMM8
      Conserved Domains (5) summary
      cd09338
      Location:842894
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:783834
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:901952
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:724776
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    3. XM_036164918.1XP_036020811.1  paxillin isoform X4

      UniProtKB/TrEMBL
      A0A1D5RMM8
      Conserved Domains (5) summary
      cd09338
      Location:753805
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:694745
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:812863
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:635687
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    4. XM_006530207.5XP_006530270.1  paxillin isoform X5

      Conserved Domains (1) summary
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    5. XM_006530205.4XP_006530268.1  paxillin isoform X3

      See identical proteins and their annotated locations for XP_006530268.1

      UniProtKB/TrEMBL
      A0A1D5RMM8
      Conserved Domains (5) summary
      cd09338
      Location:840892
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:781832
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:899950
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:722774
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:1120
      Paxillin; Paxillin family
    6. XM_006530204.4XP_006530267.1  paxillin isoform X3

      See identical proteins and their annotated locations for XP_006530267.1

      UniProtKB/TrEMBL
      A0A1D5RMM8
      Conserved Domains (5) summary
      cd09338
      Location:840892
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:781832
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:899950
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:722774
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:1120
      Paxillin; Paxillin family

    RNA

    1. XR_004942462.1 RNA Sequence