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    Ccnh cyclin H [ Mus musculus (house mouse) ]

    Gene ID: 66671, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccnhprovided by MGI
    Official Full Name
    cyclin Hprovided by MGI
    Primary source
    MGI:MGI:1913921
    See related
    Ensembl:ENSMUSG00000021548 AllianceGenome:MGI:1913921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330408H09Rik
    Summary
    Enables kinase activity. Predicted to be involved in several processes, including protein stabilization; regulation of G1/S transition of mitotic cell cycle; and transcription initiation at RNA polymerase II promoter. Located in male germ cell nucleus. Is expressed in cerebellum; cerebral cortex; cranium; limb mesenchyme; and telencephalon. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.7), CNS E18 (RPKM 11.2) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Ccnh in Genome Data Viewer
    Location:
    13 C3; 13 45.05 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (85337504..85361850)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (85189377..85213731)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35175 Neighboring gene STARR-seq mESC enhancer starr_35176 Neighboring gene smoothened homolog pseudogene Neighboring gene NADH-ubiquinone oxidoreductase chain 5-like Neighboring gene STARR-seq mESC enhancer starr_35177 Neighboring gene STARR-seq mESC enhancer starr_35178 Neighboring gene RAS p21 protein activator 1 Neighboring gene STARR-seq mESC enhancer starr_35180 Neighboring gene STARR-seq mESC enhancer starr_35181 Neighboring gene STARR-positive B cell enhancer mm9_chr13:85569683-85569983 Neighboring gene STARR-seq mESC enhancer starr_35182 Neighboring gene STARR-seq mESC enhancer starr_35183 Neighboring gene STARR-seq mESC enhancer starr_35184 Neighboring gene high mobility group box 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of CAK-ERCC2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIIH core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFIIK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIIK complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor TFIIK complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347587.1NP_001334516.1  cyclin-H isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK078059, BM899601, BQ032543, BY767531
      Consensus CDS
      CCDS84047.1
      UniProtKB/TrEMBL
      E9PWD3, Q3UUW5
      Related
      ENSMUSP00000129349.2, ENSMUST00000163600.8
    2. NM_001347588.1NP_001334517.1  cyclin-H isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AK078059, BM899601, BY767531
      UniProtKB/Swiss-Prot
      Q61458
    3. NM_023243.6NP_075732.1  cyclin-H isoform a

      See identical proteins and their annotated locations for NP_075732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK078059, BM899601, BY767531
      Consensus CDS
      CCDS26666.1
      UniProtKB/Swiss-Prot
      Q61458, Q9CVJ0, Q9JHV7
      UniProtKB/TrEMBL
      Q3UUW5
      Related
      ENSMUSP00000022030.5, ENSMUST00000022030.11
      Conserved Domains (3) summary
      TIGR00569
      Location:2308
      ccl1; cyclin ccl1
      smart00385
      Location:62152
      CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
      pfam16899
      Location:162262
      Cyclin_C_2; Cyclin C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      85337504..85361850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517325.4XP_006517388.1  cyclin-H isoform X1

      Conserved Domains (1) summary
      TIGR00569
      Location:2213
      ccl1; cyclin ccl1