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    Ifi206 interferon activated gene 206 [ Mus musculus (house mouse) ]

    Gene ID: 102639543, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ifi206provided by MGI
    Official Full Name
    interferon activated gene 206provided by MGI
    Primary source
    MGI:MGI:3646410
    See related
    Ensembl:ENSMUSG00000037849 AllianceGenome:MGI:3646410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4955; EG240921; Pyblhin-C
    Summary
    Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Predicted to be involved in several processes, including cellular response to interferon-beta; regulation of innate immune response; and regulation of macromolecule metabolic process. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 10.6), thymus adult (RPKM 10.0) and 6 other tissues See more
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    Genomic context

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    See Ifi206 in Genome Data Viewer
    Location:
    1 H3; 1 80.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173296051..173318884, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173468485..173491318, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03074 Neighboring gene STARR-seq mESC enhancer starr_03075 Neighboring gene cell adhesion molecule 3 Neighboring gene absent in melanoma 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175328755-175329056 Neighboring gene STARR-seq mESC enhancer starr_03076 Neighboring gene nuclear encoded tRNA arginine 5 (anticodon TCT) Neighboring gene STARR-positive B cell enhancer ABC_E2021 Neighboring gene STARR-seq mESC enhancer starr_03077 Neighboring gene STARR-positive B cell enhancer ABC_E1574 Neighboring gene STARR-seq mESC enhancer starr_03078 Neighboring gene STARR-positive B cell enhancer ABC_E5856 Neighboring gene STARR-positive B cell enhancer ABC_E11107 Neighboring gene STARR-seq mESC enhancer starr_03079 Neighboring gene STARR-seq mESC enhancer starr_03080 Neighboring gene STARR-positive B cell enhancer ABC_E10059 Neighboring gene STARR-positive B cell enhancer ABC_E4392 Neighboring gene interferon activated gene 214 Neighboring gene interferon activated gene 213 Neighboring gene STARR-positive B cell enhancer ABC_E11699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterisation of Ifi206: a new murine HIN-200 family member. Ludlow LE, et al. J Cell Biochem, 2008 Mar 1. PMID 17786933
    2. The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. Liu CJ, et al. J Biol Chem, 2005 Jan 28. PMID 15557274
    3. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
    4. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p206 represents the newest HIN-200 family member discovered. It has distinct pattern of expression however maintains many of the hallmarks of HIN-200 proteins. [Ifi206]
      Title: Cloning and characterisation of Ifi206: a new murine HIN-200 family member.
    2. interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation
      Title: The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of AIM2 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon activated gene 206
    Names
    signaling mucin HKR1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372436.1 → NP_001359365.1  interferon activated gene 206

      Status: VALIDATED

      Source sequence(s)
      AC084073
      Consensus CDS
      CCDS87925.1
      UniProtKB/TrEMBL
      G3UZV2
      Conserved Domains (4) summary
      cd08305
      Location:10 → 80
      Pyrin; a protein-protein interaction domain
      pfam05109
      Location:214 → 670
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02760
      Location:704 → 870
      HIN; HIN-200/IF120x domain
      pfam15265
      Location:131 → 285
      FAM196; FAM196 family

    2. NM_001372437.1 → NP_001359366.1  interferon activated gene 206

      Status: VALIDATED

      Source sequence(s)
      AC084073
      Consensus CDS
      CCDS87925.1
      UniProtKB/TrEMBL
      G3UZV2
      Related
      ENSMUSP00000134646.3, ENSMUST00000160565.4
      Conserved Domains (4) summary
      cd08305
      Location:10 → 80
      Pyrin; a protein-protein interaction domain
      pfam05109
      Location:214 → 670
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02760
      Location:704 → 870
      HIN; HIN-200/IF120x domain
      pfam15265
      Location:131 → 285
      FAM196; FAM196 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173296051..173318884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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