Ednrb endothelin receptor type B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ednrbprovided by RGD
Official Full Name: endothelin receptor type Bprovided by RGD
Primary source: RGD:2536
See related: EnsemblRapid:ENSRNOG00000010997 AllianceGenome:RGD:2536
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Etb; Ednra
Summary: Enables endothelin receptor activity and type 1 angiotensin receptor binding activity. Involved in several processes, including blood vessel diameter maintenance; cGMP-mediated signaling; and positive regulation of penile erection. Located in nuclear membrane. Used to study several diseases, including artery disease (multiple); lymphopenia; megacolon (multiple); portal hypertension; and type 2 diabetes mellitus. Biomarker of asthma; hepatopulmonary syndrome; and hypertension. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome; Waardenburg syndrome type 4A; and asthma. Orthologous to human EDNRB (endothelin receptor type B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 419.4), Brain (RPKM 227.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (87055490..87086765, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (80640839..80672115, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (88004775..88036354, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis.
Title: Activation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis.
ET-1 receptor type B (ETBR) overexpression associated with ICAM-1 downregulation leads to inflammatory attenuation in experimental autoimmune myocarditis.
Title: ET-1 receptor type B (ETBR) overexpression associated with ICAM-1 downregulation leads to inflammatory attenuation in experimental autoimmune myocarditis.
Role of Brain Endothelin Receptor Type B (ETB) in the Regulation of Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt Hypertensive Rats.
Title: Role of Brain Endothelin Receptor Type B (ET(B)) in the Regulation of Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt Hypertensive Rats.
Elevated renal afferent nerve activity in a rat model of endothelin B receptor deficiency.
Title: Elevated renal afferent nerve activity in a rat model of endothelin B receptor deficiency.
Brain size reductions associated with endothelin B receptor mutation, a cause of Hirschsprung's disease.
Title: Brain size reductions associated with endothelin B receptor mutation, a cause of Hirschsprung's disease.
Structural heart defects associated with ETB mutation, a cause of Hirschsprung disease.
Title: Structural heart defects associated with ET(B) mutation, a cause of Hirschsprung disease.
Endothelin B receptor dysfunction mediates elevated myogenic tone in cerebral arteries from aged male Fischer 344 rats.
Title: Endothelin B receptor dysfunction mediates elevated myogenic tone in cerebral arteries from aged male Fischer 344 rats.
Loss of endothelin type B receptor function improves insulin sensitivity in rats.
Title: Loss of endothelin type B receptor function improves insulin sensitivity in rats.
Endothelin-1 decreases the expression of Ephrin-A and B subtypes in cultured rat astrocytes through ETB receptors.
Title: Endothelin-1 decreases the expression of Ephrin-A and B subtypes in cultured rat astrocytes through ET(B) receptors.
Role of GRK4 in the regulation of the renal ETB receptor in hypertension.
Title: Role of GRK4 in the regulation of the renal ETB receptor in hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (168)

General gene information

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Markers

D15Wox13 (e-PCR)
- UniSTS:518424

D15Mco2 (e-PCR)
- UniSTS:240415

D15Mco3 (e-PCR)
- UniSTS:240416

PMC24270P1 (e-PCR)
- UniSTS:272250

AA818970 (e-PCR)
- UniSTS:249731

EDNRB-2 (e-PCR)
- UniSTS:253890

D15Ulb3 (e-PCR)
- UniSTS:518910

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables endothelin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables endothelin receptor activity	ISO Inferred from Sequence Orthology more info
enables endothelin receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables type 1 angiotensin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in aldosterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in chordate pharynx development	ISO Inferred from Sequence Orthology more info
involved_in developmental pigmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within developmental pigmentation	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in enteric nervous system development	ISO Inferred from Sequence Orthology more info
involved_in enteric smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in epithelial fluid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in heparin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron maturation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system development	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of penile erection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior midgut development	ISO Inferred from Sequence Orthology more info
involved_in protein transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fever generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of pH	ISO Inferred from Sequence Orthology more info
involved_in renal albumin absorption	ISO Inferred from Sequence Orthology more info
involved_in renal sodium excretion	ISO Inferred from Sequence Orthology more info
involved_in renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
involved_in renin secretion into blood stream	ISO Inferred from Sequence Orthology more info
involved_in response to endothelin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vein smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelin receptor type B

Names: ET-B; ET-BR; endothelin B receptor; endothelin receptor non-selective type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017333.1 → NP_059029.1 endothelin receptor type B precursor

See identical proteins and their annotated locations for NP_059029.1

Status: PROVISIONAL

Source sequence(s)

S65355

UniProtKB/Swiss-Prot

P21451

UniProtKB/TrEMBL

A6HUA5

Related

ENSRNOP00000014747.4, ENSRNOT00000014747.7

Conserved Domains (1) summary

cd15976
Location:102 → 397

7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

87055490..87086765 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252431.5 → XP_006252493.1 endothelin receptor type B isoform X1

See identical proteins and their annotated locations for XP_006252493.1

UniProtKB/Swiss-Prot

P21451

UniProtKB/TrEMBL

A6HUA5

Conserved Domains (1) summary

cd15976
Location:102 → 397

7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors