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    Casq2 calsequestrin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29209, updated on 9-Dec-2024

    Summary

    Official Symbol
    Casq2provided by RGD
    Official Full Name
    calsequestrin 2provided by RGD
    Primary source
    RGD:2276
    See related
    EnsemblRapid:ENSRNOG00000016243 AllianceGenome:RGD:2276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    cardCSQ
    Summary
    Enables protein homodimerization activity and protein kinase C binding activity. Involved in negative regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac muscle cell contraction; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in Z disc and sarcoplasmic reticulum. Biomarker of congestive heart failure and supravalvular aortic stenosis. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 2. Orthologous to human CASQ2 (calsequestrin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 2653.1) See more
    Orthologs
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    Genomic context

    See Casq2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (192214556..192270821)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (189526003..189582276)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (204512361..204568643)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nescient helix loop helix 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B6, pseudogene 1 Neighboring gene VANGL planar cell polarity protein 1 Neighboring gene basic proline-rich protein-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion sequestering activity  
    enables calcium ion sequestering activity  
    enables calcium-dependent protein binding  
    enables calcium-dependent protein binding  
    enables protein homodimerization activity PubMed 
    enables protein kinase C binding PubMed 
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in cardiac muscle contraction  
    involved_in cardiac muscle contraction  
    involved_in cellular response to caffeine  
    involved_in cellular response to caffeine  
    involved_in intracellular calcium ion homeostasis  
    involved_in negative regulation of potassium ion transmembrane transporter activity  
    involved_in negative regulation of potassium ion transport  
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity PubMed 
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity  
    involved_in protein polymerization  
    involved_in protein polymerization  
    involved_in regulation of cardiac muscle cell contraction PubMed 
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion PubMed 
    acts_upstream_of_or_within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
    involved_in regulation of cell communication by electrical coupling  
    involved_in regulation of cell communication by electrical coupling  
    involved_in regulation of heart rate  
    involved_in regulation of heart rate  
    involved_in regulation of membrane repolarization  
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
    involved_in sarcomere organization  
    involved_in sequestering of calcium ion  
    involved_in sequestering of calcium ion  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    is_active_in Z disc  
    located_in Z disc PubMed 
    located_in Z disc  
    located_in cytoplasm  
    part_of junctional membrane complex  
    located_in sarcoplasmic reticulum PubMed 
    located_in sarcoplasmic reticulum  
    is_active_in sarcoplasmic reticulum lumen  
    located_in sarcoplasmic reticulum lumen  
    located_in sarcoplasmic reticulum lumen  

    General protein information

    Preferred Names
    calsequestrin-2
    Names
    SR calcium binding protein
    calsequestrin 2 (cardiac muscle)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017131.2NP_058827.3  calsequestrin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      BC072547, CK602439, CO401252
      UniProtKB/Swiss-Prot
      O09177, P51868, Q6IMX1
      Related
      ENSRNOP00000086716.2, ENSRNOT00000111697.2
      Conserved Domains (4) summary
      cd03065
      Location:24143
      PDI_b_Calsequestrin_N; PDIb family, Calsequestrin subfamily, N-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...
      cd03066
      Location:145246
      PDI_b_Calsequestrin_middle; PDIb family, Calsequestrin subfamily, Middle TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...
      cd03074
      Location:247366
      PDI_b'_Calsequestrin_C; Protein Disulfide Isomerase (PDIb') family, Calsequestrin subfamily, C-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient ...
      pfam01216
      Location:22371
      Calsequestrin; Calsequestrin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      192214556..192270821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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