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    Rab8b RAB8B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab8bprovided by RGD
    Official Full Name
    RAB8B, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:628764
    See related
    AllianceGenome:RGD:628764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables TPR domain binding activity. Involved in cell-substrate junction organization; positive regulation of cell projection organization; and positive regulation of corticotropin secretion. Located in cell tip and perinuclear region of cytoplasm. Is active in presynapse. Orthologous to human RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 183.9), Thymus (RPKM 108.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab8b in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76340106..76417638, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67458921..67536466, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72641680..72714646, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene aph-1 homolog B, gamma secretase subunit like 1 Neighboring gene aph-1 homolog B, gamma secretase subunit Neighboring gene small nucleolar RNA SNORA8 Neighboring gene cytochrome c oxidase subunit 6A1, pseudogene 1 Neighboring gene uncharacterized LOC102554897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3. Armstrong J, et al. J Cell Sci, 1996 Jun. PMID 8799816
    2. Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells. Chen S, et al. J Biol Chem, 2001 Apr 20. PMID 11278749
    3. Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. Heidrych P, et al. Hum Mol Genet, 2008 Dec 1. PMID 18772196
    4. Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b. Fransen M, et al. Biochim Biophys Acta, 2008 May. PMID 18346465
    5. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, et al. Biochem J, 2008 Jul 15. PMID 18570632

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using a rodent cochlear cDNA library Rab8b is identified as an interacting partner of otoferlin.
      Title: Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form.
    2. Rab8B participates in adherens junction dynamics in the testis.
      Title: Rab8B GTPase and junction dynamics in the testis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TPR domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-substrate junction organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell projection organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of corticotropin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into peroxisome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-8B
    Names
    GTPase Rab8b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153317.3 → NP_695229.1  ras-related protein Rab-8B

      See identical proteins and their annotated locations for NP_695229.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P70550
      UniProtKB/TrEMBL
      B0BMV5
      Conserved Domains (1) summary
      cd01867
      Location:6 → 172
      Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      76340106..76417638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080935.2 → XP_038936863.1  ras-related protein Rab-8B isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:1 → 91
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_039080932.2 → XP_038936860.1  ras-related protein Rab-8B isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:6 → 82
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70550.1 GenPept UniProtKB/Swiss-Prot:P70550

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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