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    Obp3 alpha-2u globulin PGCL4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259247, updated on 27-Nov-2024

    Summary

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    Symbol
    Obp3provided by RGD
    Full Name
    alpha-2u globulin PGCL4provided by RGD
    Primary source
    RGD:708508
    See related
    EnsemblRapid:ENSRNOG00000065108 AllianceGenome:RGD:708508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables odorant binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 13981.1) See more
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    Genomic context

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    See Obp3 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (79637234..79640810, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (74842316..74845858, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (77313357..77316875, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sorting nexin family member 30 Neighboring gene transfer RNA alanine (anticodon AGC) 81 Neighboring gene solute carrier family 46, member 2 Neighboring gene zinc finger protein 37, pseudogene 6 Neighboring gene major urinary protein 4 like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. α2u-globulins mediate manipulation of host attractiveness in Toxoplasma gondii-Rattus novergicus association. Vasudevan A, et al. ISME J, 2015 Sep. PMID 25853804, Free PMC Article
    2. The major urinary protein system in the rat. Gómez-Baena G, et al. Biochem Soc Trans, 2014 Aug. PMID 25109974
    3. Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3. Portman KL, et al. Biochemistry, 2014 Apr 15. PMID 24665925
    4. Down-regulation of alpha-2u globulin in renal mitochondria of STZ-induced diabetic rats observed by a proteomic method. Sun SH, et al. Ann Endocrinol (Paris), 2012 Dec. PMID 23131471
    5. Dynamics of odorant binding to thin aqueous films of rat-OBP3. Yabuki M, et al. Chem Senses, 2011 Sep. PMID 21536621

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. T. gondii infection enhances hepatic production and urinary excretion of alpha2u-globulins in rats; alpha2u-globulins are sufficient to recapitulate male sexual attractiveness akin to effects of the infection
      Title: α2u-globulins mediate manipulation of host attractiveness in Toxoplasma gondii-Rattus novergicus association.
    2. Obp3 binding energetics are modulated by two desolvation processes with quite different thermodynamic signatures
      Title: Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3.
    3. Down-regulation of alpha-2u globulin in renal mitochondria of STZ-induced diabetic rats.
      Title: Down-regulation of alpha-2u globulin in renal mitochondria of STZ-induced diabetic rats observed by a proteomic method.
    4. Because rat-OBP3 exhibits typical odorant-binding characteristics, the results not only provide fundamental information on the kinetics of odorant mass transfer induced by the presence of OBPs in the olfactory mucus layer but also support the possibility that vertebrate OBPs may facilitate the accumulation of odorants in the olfactory epithelium
      Title: Dynamics of odorant binding to thin aqueous films of rat-OBP3.
    5. The ligand profile for three odorant binding proteins (OBPs) of the rat have been determined using a large number of odorous compounds from different chemical classes.
      Title: Odorants of different chemical classes interact with distinct odorant binding protein subtypes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108576

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables odorant binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pheromone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2u globulin PGCL4
    Names
    alpha2 urinary globulin
    major urinary protein-like
    odorant-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033958.2 → NP_001029130.2  alpha-2u globulin PGCL4 precursor

      See identical proteins and their annotated locations for NP_001029130.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variant 1, 2, and 3 encode the same protein.
      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14
      Conserved Domains (1) summary
      cd19428
      Location:26 → 179
      lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

    2. NM_001033959.2 → NP_001029131.1  alpha-2u globulin PGCL4 precursor

      See identical proteins and their annotated locations for NP_001029131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variant 1, 2, and 3 encode the same protein.
      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14
      Conserved Domains (1) summary
      cd19428
      Location:26 → 179
      lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

    3. NM_147215.2 → NP_671748.2  alpha-2u globulin PGCL4 precursor

      See identical proteins and their annotated locations for NP_671748.2

      Status: VALIDATED

      Description
      Transcript Variant: The variant (1) represents the longest transcript. Variant 1, 2, and 3 encode the same protein.
      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14
      Related
      ENSRNOP00000048604.6, ENSRNOT00000043056.8
      Conserved Domains (1) summary
      cd19428
      Location:26 → 179
      lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      79637234..79640810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109326.2 → XP_038965254.1  alpha-2u globulin PGCL4 isoform X2

      UniProtKB/TrEMBL
      A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14
      Conserved Domains (1) summary
      cd19428
      Location:26 → 179
      lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

    2. XM_063287204.1 → XP_063143274.1  alpha-2u globulin PGCL4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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