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    GPR108 G protein-coupled receptor 108 [ Homo sapiens (human) ]

    Gene ID: 56927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPR108provided by HGNC
    Official Full Name
    G protein-coupled receptor 108provided by HGNC
    Primary source
    HGNC:HGNC:17829
    See related
    Ensembl:ENSG00000125734 MIM:618491; AllianceGenome:HGNC:17829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LUSTR2
    Summary
    Predicted to be involved in negative regulation of toll-like receptor signaling pathway. Located in trans-Golgi network. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 21.4), duodenum (RPKM 17.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR108 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6729914..6737580, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6719314..6726971, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6729925..6737591, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13854 Neighboring gene TNF superfamily member 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6674384-6674960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6674961-6675535 Neighboring gene Sharpr-MPRA regulatory region 11629 Neighboring gene complement C3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6697003-6697504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6697505-6698004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6727893-6728394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6728395-6728894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9961 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:6735174-6735942 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6736406-6736560 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6736926-6737087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6738248-6739016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6739785-6740552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6742783-6743702 Neighboring gene microRNA 6791 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6745754-6746254 Neighboring gene uncharacterized LOC124904623 Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9967 Neighboring gene SH2 domain containing 3A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6760841-6761341 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6764936-6765836

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer. Lyu S, et al. Pharmacol Res, 2022 Aug. PMID 35659621
    2. GPR108 Is a Highly Conserved AAV Entry Factor. Dudek AM, et al. Mol Ther, 2020 Feb 5. PMID 31784416, Free PMC Article
    3. Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction. Meisen WH, et al. Mol Ther Methods Clin Dev, 2020 Jun 12. PMID 32280726, Free PMC Article
    4. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity. Zhao M, et al. Cell Rep, 2023 Jun 27. PMID 37330913
    5. GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. Dong D, et al. PLoS One, 2018. PMID 30332431, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
      Title: A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
    2. GPR108 is required for gambogic acid inhibiting NF-kappaB signaling in cancer.
      Title: GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer.
    3. GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
      Title: GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
    4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Risk of meningioma and common variation in genes related to innate immunity.
    6. The 18-exon human GPR107 gene is located at 9q34.2-3 and spans 86.4 kb and the cDNA encodes a 552 residue protein; murine Gpr108 cDNA encodes a 562 residue protein that has 49% identity to human GPR107.
      Title: Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC14393

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein GPR108
    Names
    lung seven transmembrane receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080452.2 → NP_001073921.1  protein GPR108 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001073921.1

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Consensus CDS
      CCDS42479.1
      UniProtKB/Swiss-Prot
      B9EJD7, Q9NPR9
      UniProtKB/TrEMBL
      A8K7F3
      Related
      ENSP00000264080.5, ENST00000264080.12
      Conserved Domains (1) summary
      pfam06814
      Location:215 → 503
      Lung_7-TM_R; Lung seven transmembrane receptor

    2. NM_001394714.1 → NP_001381643.1  protein GPR108 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Consensus CDS
      CCDS45940.1
      UniProtKB/TrEMBL
      B9EK73, G5E9L6
      Conserved Domains (1) summary
      pfam06814
      Location:1 → 261
      Lung_7-TM_R; Lung seven transmembrane receptor

    3. NM_001394715.1 → NP_001381644.1  protein GPR108 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Consensus CDS
      CCDS45940.1
      UniProtKB/TrEMBL
      B9EK73, G5E9L6
      Conserved Domains (1) summary
      pfam06814
      Location:1 → 261
      Lung_7-TM_R; Lung seven transmembrane receptor

    4. NM_001394716.1 → NP_001381645.1  protein GPR108 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Consensus CDS
      CCDS45940.1
      UniProtKB/TrEMBL
      B9EK73, G5E9L6
      Conserved Domains (1) summary
      pfam06814
      Location:1 → 261
      Lung_7-TM_R; Lung seven transmembrane receptor

    5. NM_001394717.1 → NP_001381646.1  protein GPR108 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Conserved Domains (1) summary
      cl21735
      Location:216 → 418
      Lung_7-TM_R; Lung seven transmembrane receptor

    6. NM_001394718.1 → NP_001381647.1  protein GPR108 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008760
      UniProtKB/TrEMBL
      A8K7F3
      Conserved Domains (1) summary
      pfam06814
      Location:216 → 503
      Lung_7-TM_R; Lung seven transmembrane receptor

    7. NM_001394719.1 → NP_001381648.1  protein GPR108 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008760
      UniProtKB/TrEMBL
      A8K7F3
      Conserved Domains (1) summary
      pfam06814
      Location:216 → 450
      Lung_7-TM_R; Lung seven transmembrane receptor

    8. NM_001394720.1 → NP_001381649.1  protein GPR108 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008760
      UniProtKB/TrEMBL
      A8K7F3
      Conserved Domains (1) summary
      pfam06814
      Location:216 → 487
      Lung_7-TM_R; Lung seven transmembrane receptor

    9. NM_001394721.1 → NP_001381650.1  protein GPR108 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008760
      UniProtKB/TrEMBL
      A8K7F3
      Conserved Domains (1) summary
      pfam06814
      Location:199 → 486
      Lung_7-TM_R; Lung seven transmembrane receptor

    10. NM_001394722.1 → NP_001381651.1  protein GPR108 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008760
      UniProtKB/TrEMBL
      A8K7F3
      Conserved Domains (1) summary
      pfam06814
      Location:216 → 478
      Lung_7-TM_R; Lung seven transmembrane receptor

    11. NM_001394723.1 → NP_001381652.1  protein GPR108 isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008760
      UniProtKB/TrEMBL
      A8K7F3
      Conserved Domains (1) summary
      pfam06814
      Location:216 → 450
      Lung_7-TM_R; Lung seven transmembrane receptor

    12. NM_001394724.1 → NP_001381653.1  protein GPR108 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Conserved Domains (1) summary
      cl21735
      Location:1 → 176
      Lung_7-TM_R; Lung seven transmembrane receptor

    13. NM_001394725.1 → NP_001381654.1  protein GPR108 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Conserved Domains (1) summary
      cl21735
      Location:1 → 208
      Lung_7-TM_R; Lung seven transmembrane receptor

    14. NM_001394726.1 → NP_001381655.1  protein GPR108 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Conserved Domains (1) summary
      cl21735
      Location:1 → 208
      Lung_7-TM_R; Lung seven transmembrane receptor

    15. NM_001394727.1 → NP_001381656.1  protein GPR108 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC008760
      UniProtKB/TrEMBL
      B9EK73
      Conserved Domains (1) summary
      cl21735
      Location:1 → 236
      Lung_7-TM_R; Lung seven transmembrane receptor

    16. NM_001394728.1 → NP_001381657.1  protein GPR108 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Conserved Domains (1) summary
      cl21735
      Location:1 → 208
      Lung_7-TM_R; Lung seven transmembrane receptor

    17. NM_020171.2 → NP_064556.1  protein GPR108 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008760
      Consensus CDS
      CCDS45940.1
      UniProtKB/TrEMBL
      B9EK73, G5E9L6
      Related
      ENSP00000401284.2, ENST00000430424.8
      Conserved Domains (1) summary
      pfam06814
      Location:1 → 261
      Lung_7-TM_R; Lung seven transmembrane receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      6729914..6737580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439110.1 → XP_047295066.1  protein GPR108 isoform X1

      UniProtKB/TrEMBL
      B9EK73, G5E9L6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      6719314..6726971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321503.1 → XP_054177478.1  protein GPR108 isoform X1

      UniProtKB/TrEMBL
      B9EK73, G5E9L6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NPR9.3 GenPept UniProtKB/Swiss-Prot:Q9NPR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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