Tac3 tachykinin precursor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tac3provided by RGD
Official Full Name: tachykinin precursor 3provided by RGD
Primary source: RGD:3809
See related: EnsemblRapid:ENSRNOG00000004229 AllianceGenome:RGD:3809
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tac2
Summary: Predicted to enable neuromedin K receptor binding activity and substance K receptor binding activity. Involved in positive regulation of blood pressure. Predicted to be located in extracellular space. Biomarker of hypertension. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 10 with or without anosmia. Orthologous to human TAC3 (tachykinin precursor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 38.6), Brain (RPKM 32.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65447817..65454427)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63562552..63569170)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (71023976..71030582)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

At the onset of puberty, the densities of kisspeptin and neurokinin B IR cells were significantly higher in the high-fat diet group than in the control group
Title: The effect of diet control on puberty onset and immunoreactivity of kisspeptin and neurokinin B in female rats.
The expressions of each mRNA (Kiss1, Tac3, and Pdyn) and each peptide (kisspeptin, NKB, and DynA) in the ARC significantly decreased in Zucker fatty rats compared with Zucker lean rats
Title: Expression of hypothalamic kisspeptin, neurokinin B, and dynorphin A neurons attenuates in female Zucker fatty rats.
data suggest that endogenous NeuroKinin B-Neurokinin 3 Receptor signalling plays a role in controlling the timing of puberty.
Title: Neurokinin B receptor antagonism decreases luteinising hormone pulse frequency and amplitude and delays puberty onset in the female rat.
NKB agonist stimulates FSH secretion in a strikingly developmental-dependent manner
Title: Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
The divergent regulation of kisspeptin and NKB peptide contents in the arcuate nucleus as a function of sex and steroid milieu enlarge our understanding on how these neuropeptides are posttranscriptionally regulated in KNDy neurons.
Title: Disparate changes in kisspeptin and neurokinin B expression in the arcuate nucleus after sex steroid manipulation reveal differential regulation of the two KNDy peptides in rats.
Data indicate that the suppression of the GnRH pulse generator by acute systemic stress equires hypothalamic NKB/neurokinin B (NKB) receptor (NK3R) signaling.
Title: Neurokinin B signaling in the female rat: a novel link between stress and reproduction.
Data suggest few hypothalamic genes are sexually dimorphic during postnatal development; only Tac2/neurokinin B, Esr1 (estrogen receptor 1), and Kiss1 (KiSS-1 metastasis-suppressor) are dimorphic (i.e., higher in females) in developing preoptic area.
Title: Molecular profiling of postnatal development of the hypothalamus in female and male rats.
Role of Neurokinin B and Dynorphin A in pituitary gonadotroph and somatolactotroph cell lines.
Title: Role of Neurokinin B and Dynorphin A in pituitary gonadotroph and somatolactotroph cell lines.
Data suggest that the earlier accelerated GnRH pulse generator frequency and advanced puberty with obesogenic diets might be associated with premature up-regulation of kisspeptin and NKB signaling in the hypothalamus of the female rat.
Title: High-fat diet increases LH pulse frequency and kisspeptin-neurokinin B expression in puberty-advanced female rats.
Data show that arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons are essential for tonic gonadotropin secretion, the rise in LH after removal of E(2), and the E(2) modulation of body weight.
Title: Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuromedin K receptor binding	ISO Inferred from Sequence Orthology more info
enables substance K receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in tachykinin receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tachykinin-3

Names: neurokinin B; tachykinin 2; tachykinin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.