CERK1 chitin elicitor receptor kinase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CERK1
Official Full Name: chitin elicitor receptor kinase 1
Primary source: TAIR:AT3G21630
Locus tag: AT3G21630
See related: Araport:AT3G21630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtCERK1; AtLYK1; chitin elicitor receptor kinase 1; LYK1; LYSM DOMAIN RECEPTOR-LIKE KINASE 1; LYSM RLK1; LysM-containing receptor-like kinase 1
Summary: LysM receptor-like kinase. Essential in the perception and transduction of the chitin oligosaccharide elicitor. Involved in chitin-mediated plant innate immunity. Located in the plasma membrane.
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Genomic context

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See CERK1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 12

Sequence:: Chromosome: 3; NC_003074.8 (7615357..7618671, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Arabidopsis thaliana LysM-containing Receptor-Like Kinase 2 is required for elicitor-induced resistance to pathogens.
Title: The Arabidopsis thaliana LysM-containing Receptor-Like Kinase 2 is required for elicitor-induced resistance to pathogens.
The juxtamembrane domains of Arabidopsis CERK1, BAK1, and FLS2 play a conserved role in chitin-induced signaling.
Title: The juxtamembrane domains of Arabidopsis CERK1, BAK1, and FLS2 play a conserved role in chitin-induced signaling.
Arabidopsis pattern-recognition receptor chitin elicitor receptor kinase 1 (CERK1) is autophosphorylated in unstimulated cells at tyrosine(428), a modification that is required for CERK1 activation upon binding to the fungal cell wall component chitin.
Title: A Tyrosine Phosphorylation Cycle Regulates Fungal Activation of a Plant Receptor Ser/Thr Kinase.
These data support that plants, like animals, have selected as microbe-associated molecular patterns (MAMPs) the linear 1,3-beta-d-glucans present in the walls of fungi and oomycetes. The data also suggest that CERK1 functions as an immune co-receptor for linear 1,3-beta-d-glucans in a similar way to its proposed function in the recognition of fungal chito-oligosaccharides and bacterial peptidoglycan MAMPs.
Title: Non-branched β-1,3-glucan oligosaccharides trigger immune responses in Arabidopsis.
co-expression of PUB12 in Nicotiana benthamiana reduced the accumulation of CERK1. The pub12 pub13 mutant exhibited enhanced chitin-induced immune responses such as ROS production, MAPK activation, and callose deposition
Title: Arabidopsis ubiquitin ligase PUB12 interacts with and negatively regulates Chitin Elicitor Receptor Kinase 1 (CERK1).
Nucleoporin NUP88/MOS7 is required for manifestation of phenotypes associated with the Arabidopsis CHITIN ELICITOR RECEPTOR KINASE1 mutant cerk1-4
Title: Nucleoporin NUP88/MOS7 is required for manifestation of phenotypes associated with the Arabidopsis CHITIN ELICITOR RECEPTOR KINASE1 mutant cerk1-4.
Study indicated that CERK1 physically interacts with ANNEXIN 1 (ANN1), which was reported to form a calcium-permeable channel that contributes to the NaCl-induced [Ca(2+) ]cyt signal. In turn, ann1 mutants showed elevated chitin-induced rapid responses
Title: Chitin receptor CERK1 links salt stress and chitin-triggered innate immunity in Arabidopsis.
PBL27 interacts with both CERK1 and the MAPK kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK kinase activation and disease resistance to Alternaria brassicicola.
Title: The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation.
the phosphorylation of specific residues in the kinase domain of CERK1 contributes to the regulation of downstream signaling.
Title: Autophosphorylation of Specific Threonine and Tyrosine Residues in Arabidopsis CERK1 is Essential for the Activation of Chitin-Induced Immune Signaling.
Cerk1 plays a chitin-independent role in a pathogen-induced cell death control.
Title: A novel Arabidopsis CHITIN ELICITOR RECEPTOR KINASE 1 (CERK1) mutant with enhanced pathogen-induced cell death and altered receptor processing.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_113058.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables chitin binding	IDA Inferred from Direct Assay more info	PubMed
enables chitosan binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to chitin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to chitin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to molecule of bacterial origin	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of molecule of fungal origin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within detection of molecule of fungal origin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of peptidoglycan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of plant-type hypersensitive response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to chitin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chitin elicitor receptor kinase 1

NP_566689.2

chitin elicitor receptor kinase 1 (CERK1); FUNCTIONS IN: transmembrane receptor protein kinase activity, receptor signaling protein activity, kinase activity; INVOLVED IN: defense response to fungus, incompatible interaction, response to chitin, detection of molecule of fungal origin; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidoglycan-binding lysin domain (InterPro:IPR018392), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: protein kinase family protein / peptidoglycan-binding LysM domain-containing protein (TAIR:AT1G51940.1); Has 117788 Blast hits to 116484 proteins in 4898 species: Archae - 166; Bacteria - 13638; Metazoa - 43401; Fungi - 9900; Plants - 32885; Viruses - 579; Other Eukaryotes - 17219 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

7615357..7618671 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113058.4 → NP_566689.2 chitin elicitor receptor kinase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

A8R7E6, Q9LVE3

UniProtKB/TrEMBL

A0A5S9XEF0, A0A654F9D5

Conserved Domains (2) summary

PRK10783
Location:104 → 202

mltD; membrane-bound lytic murein transglycosylase D; Provisional

cl21453
Location:328 → 587

PKc_like; Protein Kinases, catalytic domain