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    Slco2a1 solute carrier organic anion transporter family, member 2a1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slco2a1provided by RGD
    Official Full Name
    solute carrier organic anion transporter family, member 2a1provided by RGD
    Primary source
    RGD:3051
    See related
    EnsemblRapid:ENSRNOG00000009005 AllianceGenome:RGD:3051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Matr1; PHOAR2; OATP2A1; Slc21a2
    Summary
    Predicted to enable prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in prostaglandin transport and sodium-independent organic anion transport. Predicted to be located in basal plasma membrane. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in primary hypertrophic osteoarthropathy. Orthologous to human SLCO2A1 (solute carrier organic anion transporter family member 2A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 479.9), Liver (RPKM 266.7) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slco2a1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112467739..112551923)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103588916..103672546)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111495443..111577320)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene receptor-like tyrosine kinase Neighboring gene uncharacterized LOC102549824 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480222 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene SRP receptor subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Experimental Evidence for Resecretion of PGE(2) across Rat Alveolar Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport. Nakanishi T, et al. J Pharmacol Exp Ther, 2019 Feb. PMID 30420359
    2. Expression of PGT in MDCK cell monolayers: polarized apical localization and induction of active PG transport. Endo S, et al. Am J Physiol Renal Physiol, 2002 Apr. PMID 11880322
    3. Identification and characterization of a prostaglandin transporter. Kanai N, et al. Science, 1995 May 12. PMID 7754369
    4. Molecular cloning of matrin F/G: A DNA binding protein of the nuclear matrix that contains putative zinc finger motifs. Hakes DJ, et al. Proc Natl Acad Sci U S A, 1991 Jul 15. PMID 2068100, Free PMC Article
    5. Characterization of a major modifier locus for polycystic kidney disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved with a mouse modifier locus for Alport syndrome. Bihoreau MT, et al. Hum Mol Genet, 2002 Sep 1. PMID 12189169

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OATP2A1 mediates transcellular transport of PGE2 in the apical membrane-to-basolateral direction in alveolar epithelium.
      Title: Experimental Evidence for Resecretion of PGE(2) across Rat Alveolar Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport.
    2. endogenous PGT is exocytically inserted into the collecting duct apical membrane, where it could control the concentration of luminal PGs
      Title: Expression of PGT in MDCK cell monolayers: polarized apical localization and induction of active PG transport.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables prostaglandin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 2A1
    Names
    PGT
    matrin F/G 1
    prostaglandin transporter
    solute carrier family 21 (prostaglandin transporter), member 2
    solute carrier family 21 member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022667.4 → NP_073158.2  solute carrier organic anion transporter family member 2A1

      See identical proteins and their annotated locations for NP_073158.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q00910
      UniProtKB/TrEMBL
      A0A0G2JV79, A6I2I3
      Related
      ENSRNOP00000110951.1, ENSRNOT00000168642.1
      Conserved Domains (3) summary
      cd06174
      Location:166 → 425
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:442 → 496
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      TIGR00805
      Location:1 → 630
      oat; sodium-independent organic anion transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      112467739..112551923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243655.4 → XP_006243717.1  solute carrier organic anion transporter family member 2A1 isoform X1

      UniProtKB/Swiss-Prot
      Q00910
      Related
      ENSRNOP00000012162.7, ENSRNOT00000012162.8
      Conserved Domains (2) summary
      cd06174
      Location:67 → 326
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:343 → 397
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

    2. XM_039080798.2 → XP_038936726.1  solute carrier organic anion transporter family member 2A1 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:1 → 370
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00910.3 GenPept UniProtKB/Swiss-Prot:Q00910

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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