Gde1 glycerophosphodiester phosphodiesterase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gde1provided by RGD
Official Full Name: glycerophosphodiester phosphodiesterase 1provided by RGD
Primary source: RGD:621788
See related: EnsemblRapid:ENSRNOG00000050445 AllianceGenome:RGD:621788
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mir16
Summary: Predicted to enable glycerophosphodiester phosphodiesterase activity; glycerophosphoinositol glycerophosphodiesterase activity; and lysophospholipase activity. Predicted to be involved in N-acylethanolamine metabolic process; ethanolamine metabolic process; and phospholipid metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GDE1 (glycerophosphodiester phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 1262.0), Kidney (RPKM 834.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (182451182..182466569, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (173016984..173032396, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (188367550..188407125, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycerophosphodiester phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerophosphodiester phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables glycerophosphodiester phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycerophosphoinositol glycerophosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables glycerophosphoinositol glycerophosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables lysophospholipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in N-acylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within N-acylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acylethanolamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ethanolamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glycerophosphodiester phosphodiesterase 1

Names: glycerophosphoinositol glycerophosphodiesterase GDE1; lysophospholipase D GDE1; membrane-interacting protein of RGS16

NP_116004.2

EC 3.1.4.44

XP_063128560.1

EC 3.1.4.44

XP_063128562.1

EC 3.1.4.44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032615.2 → NP_116004.2 glycerophosphodiester phosphodiesterase 1

See identical proteins and their annotated locations for NP_116004.2

Status: PROVISIONAL

Source sequence(s)

BC070897

UniProtKB/Swiss-Prot

Q6IRJ6, Q9JL55

UniProtKB/TrEMBL

A6I8I2, M0R5Q9

Related

ENSRNOP00000064735.3, ENSRNOT00000073233.4

Conserved Domains (1) summary

cd08573
Location:68 → 323

GDPD_GDE1; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

182451182..182466569 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272492.1 → XP_063128562.1 glycerophosphodiester phosphodiesterase 1 isoform X1
XM_063272490.1 → XP_063128560.1 glycerophosphodiester phosphodiesterase 1 isoform X1