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    DENND3 DENN domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 22898, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DENND3provided by HGNC
    Official Full Name
    DENN domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:29134
    See related
    Ensembl:ENSG00000105339 MIM:617503; AllianceGenome:HGNC:29134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in endosome to lysosome transport; protein catabolic process; and regulation of Rab protein signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 17.0), lung (RPKM 14.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DENND3 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141128589..141195804)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142248713..142315919)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142138688..142205903)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047320-142047944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047945-142048570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142048571-142049195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142051549-142052338 Neighboring gene uncharacterized LOC105375784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142069799-142070496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:142077205-142077706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142082933-142083432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142083433-142084432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142084444-142085234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142085235-142086025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142097256-142097756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28040 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:142104647-142104880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142105126-142106125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142114470-142115018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142115019-142115566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142121985-142122506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142122507-142123026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142128597-142129165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142137284-142138115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142138949-142139779 Neighboring gene DENND3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142144757-142145375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142163840-142164798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142167099-142167874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28046 Neighboring gene Sharpr-MPRA regulatory region 5779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142183015-142183516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142183517-142184016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142191187-142191687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142194501-142195455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142202224-142202724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142202725-142203225 Neighboring gene uncharacterized LOC105375785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142218415-142218922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142218923-142219430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142229255-142229790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142231827-142232566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142232567-142233305 Neighboring gene solute carrier family 45 member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142237903-142238756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142239613-142240468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142240469-142241324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142248324-142248883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142248884-142249442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142250482-142251464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142256416-142257096 Neighboring gene SLC45A4 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway. Li Y, et al. Hepatol Int, 2023 Jun. PMID 36729283
    2. A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy. Xu J, et al. J Biol Chem, 2018 Mar 23. PMID 29352104, Free PMC Article
    3. Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction. Xu J, et al. J Biol Chem, 2017 Apr 28. PMID 28249939, Free PMC Article
    4. Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients. Weber F, et al. Pharmacogenomics J, 2012 Jun. PMID 21502966
    5. Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy. Xu J, et al. EMBO Rep, 2015 Jun. PMID 25925668, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway.
      Title: DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway.
    2. show that DENND3 binds actin through a surface of positively charged residues on the PHenn domain of Ran12
      Title: A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy.
    3. DENND3 is the exchange factor for the small GTPase Rab12 regulated through an intramolecular interaction
      Title: Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction.
    4. a novel signaling pathway identified whereby starvation-induced activation of ULK leads to phosphorylation of endogenous DENND3, with subsequent activation of Rab12 and initiation of membrane trafficking events required for autophagy
      Title: Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0870

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 3
    Names
    DENN/MADD domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001352890.3 → NP_001339819.2  DENN domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC040970, BC110827, BX331731, CA413644
      Consensus CDS
      CCDS87629.1
      UniProtKB/TrEMBL
      E9PF32, H0YAY3
      Related
      ENSP00000428714.1, ENST00000519811.6
      Conserved Domains (5) summary
      smart00801
      Location:435 → 497
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00039
      Location:1028 → 1063
      7WD40; WD40 repeat [structural motif]
      pfam02141
      Location:185 → 371
      DENN; DENN (AEX-3) domain
      cl04085
      Location:122 → 158
      uDENN; uDENN domain
      cl25539
      Location:1004 → 1276
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001352891.3 → NP_001339820.2  DENN domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC040970, AL544320, BC110827, BX331731
      Related
      ENSP00000430695.1, ENST00000518347.5
      Conserved Domains (1) summary
      cl04085
      Location:122 → 158
      uDENN; uDENN domain

    3. NM_001362798.2 → NP_001349727.1  DENN domain-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AA760923, AC040970
      UniProtKB/TrEMBL
      H0YAY3
      Conserved Domains (5) summary
      smart00801
      Location:435 → 497
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00039
      Location:1028 → 1063
      7WD40; WD40 repeat [structural motif]
      pfam02141
      Location:185 → 371
      DENN; DENN (AEX-3) domain
      cl04085
      Location:122 → 158
      uDENN; uDENN domain
      cl25539
      Location:1019 → 1120
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_014957.5 → NP_055772.3  DENN domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC040970, BX331731, CB989310
      Consensus CDS
      CCDS34947.1
      UniProtKB/Swiss-Prot
      A2RUS2, B7ZM28, O94947, Q2TAM7, Q6ZMS6, Q96DK3
      Related
      ENSP00000262585.2, ENST00000262585.6
      Conserved Domains (5) summary
      smart00801
      Location:368 → 430
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00039
      Location:961 → 996
      7WD40; WD40 repeat [structural motif]
      pfam02141
      Location:118 → 304
      DENN; DENN (AEX-3) domain
      cl04085
      Location:55 → 91
      uDENN; uDENN domain
      cl25539
      Location:937 → 1209
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_148197.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC040970, BC110827, BX331731, CA413644

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      141128589..141195804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516933.3 → XP_011515235.2  DENN domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      H0YAY3
      Conserved Domains (5) summary
      smart00801
      Location:435 → 497
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00039
      Location:1028 → 1063
      7WD40; WD40 repeat [structural motif]
      pfam02141
      Location:185 → 371
      DENN; DENN (AEX-3) domain
      cl04085
      Location:122 → 158
      uDENN; uDENN domain
      cl25539
      Location:1019 → 1120
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_011516934.4 → XP_011515236.2  DENN domain-containing protein 3 isoform X6

      UniProtKB/TrEMBL
      H0YAY3
      Conserved Domains (5) summary
      smart00801
      Location:435 → 497
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00039
      Location:1028 → 1063
      7WD40; WD40 repeat [structural motif]
      pfam02141
      Location:185 → 371
      DENN; DENN (AEX-3) domain
      cl04085
      Location:122 → 158
      uDENN; uDENN domain
      cl25539
      Location:1019 → 1120
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_047421591.1 → XP_047277547.1  DENN domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      H0YAY3

    4. XM_047421595.1 → XP_047277551.1  DENN domain-containing protein 3 isoform X10

      UniProtKB/TrEMBL
      H0YAY3

    5. XM_005250841.5 → XP_005250898.3  DENN domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      H0YAY3
      Related
      ENSP00000428276.1, ENST00000518668.5
      Conserved Domains (5) summary
      smart00801
      Location:393 → 445
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00039
      Location:976 → 1011
      7WD40; WD40 repeat [structural motif]
      pfam02141
      Location:185 → 371
      DENN; DENN (AEX-3) domain
      cl04085
      Location:122 → 158
      uDENN; uDENN domain
      cl25539
      Location:952 → 1224
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_047421592.1 → XP_047277548.1  DENN domain-containing protein 3 isoform X7

      UniProtKB/TrEMBL
      H0YAY3

    7. XM_047421598.1 → XP_047277554.1  DENN domain-containing protein 3 isoform X13

      UniProtKB/TrEMBL
      H0YAY3

    8. XM_047421593.1 → XP_047277549.1  DENN domain-containing protein 3 isoform X8

      UniProtKB/TrEMBL
      H0YAY3

    9. XM_047421597.1 → XP_047277553.1  DENN domain-containing protein 3 isoform X12

      UniProtKB/TrEMBL
      H0YAY3

    10. XM_005250840.6 → XP_005250897.3  DENN domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      H0YAY3
      Conserved Domains (5) summary
      smart00801
      Location:393 → 445
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00039
      Location:976 → 1011
      7WD40; WD40 repeat [structural motif]
      pfam02141
      Location:185 → 371
      DENN; DENN (AEX-3) domain
      cl04085
      Location:122 → 158
      uDENN; uDENN domain
      cl25539
      Location:967 → 1068
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_005250842.5 → XP_005250899.1  DENN domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      H0YAY3
      Conserved Domains (6) summary
      smart00801
      Location:357 → 419
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      COG2319
      Location:919 → 1108
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:950 → 985
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:941 → 1042
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl04085
      Location:122 → 158
      uDENN; uDENN domain
      cl11519
      Location:170 → 293
      DENN; DENN (AEX-3) domain

    12. XM_047421594.1 → XP_047277550.1  DENN domain-containing protein 3 isoform X9

      UniProtKB/TrEMBL
      H0YAY3

    13. XM_047421596.1 → XP_047277552.1  DENN domain-containing protein 3 isoform X11

      UniProtKB/TrEMBL
      H0YAY3

    14. XM_047421599.1 → XP_047277555.1  DENN domain-containing protein 3 isoform X14

      UniProtKB/TrEMBL
      H0YAY3

    15. XM_011516937.3 → XP_011515239.2  DENN domain-containing protein 3 isoform X16

      Conserved Domains (3) summary
      smart00801
      Location:435 → 497
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:185 → 371
      DENN; DENN (AEX-3) domain
      cl04085
      Location:122 → 158
      uDENN; uDENN domain

    16. XM_017013242.2 → XP_016868731.1  DENN domain-containing protein 3 isoform X15

      UniProtKB/Swiss-Prot
      A2RUS2, B7ZM28, O94947, Q2TAM7, Q6ZMS6, Q96DK3
      Conserved Domains (5) summary
      smart00801
      Location:187 → 249
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      COG2319
      Location:749 → 938
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:780 → 815
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:771 → 872
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl11519
      Location:6 → 123
      DENN; DENN (AEX-3) domain

    17. XM_047421600.1 → XP_047277556.1  DENN domain-containing protein 3 isoform X18

    18. XM_011516938.4 → XP_011515240.1  DENN domain-containing protein 3 isoform X17

      Conserved Domains (4) summary
      smart00801
      Location:91 → 153
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      COG2319
      Location:653 → 842
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:684 → 719
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:675 → 776
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    19. XM_047421601.1 → XP_047277557.1  DENN domain-containing protein 3 isoform X20

    20. XM_011516939.4 → XP_011515241.1  DENN domain-containing protein 3 isoform X19

      See identical proteins and their annotated locations for XP_011515241.1

      Conserved Domains (3) summary
      COG2319
      Location:496 → 685
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:527 → 562
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:518 → 619
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    21. XM_011516940.3 → XP_011515242.1  DENN domain-containing protein 3 isoform X19

      See identical proteins and their annotated locations for XP_011515242.1

      Conserved Domains (3) summary
      COG2319
      Location:496 → 685
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:527 → 562
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:518 → 619
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_007060719.1 RNA Sequence

    2. XR_007060720.1 RNA Sequence

    3. XR_928312.4 RNA Sequence

    4. XR_007060722.1 RNA Sequence

    5. XR_007060721.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      142248713..142315919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360146.1 → XP_054216121.1  DENN domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      H0YAY3

    2. XM_054360151.1 → XP_054216126.1  DENN domain-containing protein 3 isoform X6

      UniProtKB/TrEMBL
      H0YAY3

    3. XM_054360148.1 → XP_054216123.1  DENN domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      H0YAY3

    4. XM_054360155.1 → XP_054216130.1  DENN domain-containing protein 3 isoform X10

      UniProtKB/TrEMBL
      H0YAY3

    5. XM_054360149.1 → XP_054216124.1  DENN domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      H0YAY3

    6. XM_054360152.1 → XP_054216127.1  DENN domain-containing protein 3 isoform X7

      UniProtKB/TrEMBL
      H0YAY3

    7. XM_054360158.1 → XP_054216133.1  DENN domain-containing protein 3 isoform X13

      UniProtKB/TrEMBL
      H0YAY3

    8. XM_054360153.1 → XP_054216128.1  DENN domain-containing protein 3 isoform X8

      UniProtKB/TrEMBL
      H0YAY3

    9. XM_054360157.1 → XP_054216132.1  DENN domain-containing protein 3 isoform X12

      UniProtKB/TrEMBL
      H0YAY3

    10. XM_054360147.1 → XP_054216122.1  DENN domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      H0YAY3

    11. XM_054360150.1 → XP_054216125.1  DENN domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      H0YAY3

    12. XM_054360154.1 → XP_054216129.1  DENN domain-containing protein 3 isoform X9

      UniProtKB/TrEMBL
      H0YAY3

    13. XM_054360156.1 → XP_054216131.1  DENN domain-containing protein 3 isoform X11

      UniProtKB/TrEMBL
      H0YAY3

    14. XM_054360159.1 → XP_054216134.1  DENN domain-containing protein 3 isoform X14

      UniProtKB/TrEMBL
      H0YAY3

    15. XM_054360162.1 → XP_054216137.1  DENN domain-containing protein 3 isoform X16

    16. XM_054360160.1 → XP_054216135.1  DENN domain-containing protein 3 isoform X15

      UniProtKB/Swiss-Prot
      A2RUS2, B7ZM28, O94947, Q2TAM7, Q6ZMS6, Q96DK3

    17. XM_054360161.1 → XP_054216136.1  DENN domain-containing protein 3 isoform X15

      UniProtKB/Swiss-Prot
      A2RUS2, B7ZM28, O94947, Q2TAM7, Q6ZMS6, Q96DK3

    18. XM_054360163.1 → XP_054216138.1  DENN domain-containing protein 3 isoform X21

    19. XM_054360166.1 → XP_054216141.1  DENN domain-containing protein 3 isoform X20

    20. XM_054360164.1 → XP_054216139.1  DENN domain-containing protein 3 isoform X19

    21. XM_054360165.1 → XP_054216140.1  DENN domain-containing protein 3 isoform X19

    RNA

    1. XR_008487823.1 RNA Sequence

    2. XR_008487824.1 RNA Sequence

    3. XR_008487825.1 RNA Sequence

    4. XR_008487827.1 RNA Sequence

    5. XR_008487826.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RUS2.2 GenPept UniProtKB/Swiss-Prot:A2RUS2

    Gene LinkOut

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