Aqp5 aquaporin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aqp5provided by RGD
Official Full Name: aquaporin 5provided by RGD
Primary source: RGD:2144
See related: AllianceGenome:RGD:2144
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and water channel activity. Involved in carbon dioxide transport. Located in apical plasma membrane. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in Bothnian type palmoplantar keratoderma. Orthologous to human AQP5 (aquaporin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 617.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132601528..132605060)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130722675..130726207)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (141249044..141252576)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury in Rats.
Title: Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury in Rats.
Role of aquaporin 5 and glandular blood flow in the acetylcholine-induced secretion of saliva in rats.
Title: Role of aquaporin 5 and glandular blood flow in the acetylcholine-induced secretion of saliva in rats.
Evaluation of the Content of Aquaporin-5 and Epithelial Sodium Channel in the Lungs of Rats during the Development of Toxic Pulmonary Edema Caused by Intoxication with Acylating Pulmonotoxicants.
Title: Evaluation of the Content of Aquaporin-5 and Epithelial Sodium Channel in the Lungs of Rats during the Development of Toxic Pulmonary Edema Caused by Intoxication with Acylating Pulmonotoxicants.
Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation.
Title: Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation.
The Role of TREK-1 and AQP5 in Gonadocorticoid-Related Voice Disorders.
Title: The Role of TREK-1 and AQP5 in Gonadocorticoid-Related Voice Disorders.
FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary Gland.
Title: FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary Gland.
Study demonstrated that protein abundances were significantly changed in the submandibular gland (SMG) from the spontaneously hypertensive rats (SHR) compared with the glands from controls. Among the proteins that were altered, AQP5 and parvalbumin were among those that exhibited the greatest changes in the proteomic analysis and were further validated. Secretion from the SMGs was obviously decreased in the SHR group.
Title: Proteomic analysis reveals an impaired Ca(2+)/AQP5 pathway in the submandibular gland in hypertension.
AQP5 forms functional water channels in the rodent lens, and suggest that dynamic membrane insertion of AQP5 may regulate water fluxes in the lens by modulating water permeability in the outer cortex.
Title: Dynamic functional contribution of the water channel AQP5 to the water permeability of peripheral lens fiber cells.
the decrease in AQP1 protein levels in the endothelium and AQP5 in gland ductal cells of irradiated animals may have hindered the removal of water from the lumen of ductal cells, inducing a delay in water absorption and triggering a slight lumen increase.
Title: Effect of low radiation dose on the expression and location of aquaporins in rat submandibular gland.
The expression of AQP1 and AQP5 was determined by Western immunoblotting.
Title: Expression of aquaporins 1 and 5 in a model of ventilator-induced lung injury and its relation to tidal volume.

Submit: New GeneRIF Correction See all GeneRIFs (56)

General gene information

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Markers

Aqp5 (e-PCR), detects polymorphism
- UniSTS:530944

RH134628 (e-PCR)
- UniSTS:217907

RH94612 (e-PCR)
- UniSTS:119860

Aqp5 (e-PCR), detects polymorphism
- UniSTS:186494

Aqp5 (e-PCR), detects polymorphism
- UniSTS:209566

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	IEA Inferred from Electronic Annotation more info
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables water channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbon dioxide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in carbon dioxide transport	IEA Inferred from Electronic Annotation more info
involved_in carbon dioxide transport	ISO Inferred from Sequence Orthology more info
involved_in cellular hypotonic response	IEA Inferred from Electronic Annotation more info
involved_in cellular hypotonic response	ISO Inferred from Sequence Orthology more info
involved_in cellular hypotonic response	ISS Inferred from Sequence or Structural Similarity more info
involved_in odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in pancreatic juice secretion	IEA Inferred from Electronic Annotation more info
involved_in pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: aquaporin-5

Names: AQP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.