Nlgn2 neuroligin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlgn2provided by RGD
Official Full Name: neuroligin 2provided by RGD
Primary source: RGD:621118
See related: EnsemblRapid:ENSRNOG00000015430 AllianceGenome:RGD:621118
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including positive regulation of protein localization; presynapse organization; and regulation of synapse assembly. Acts upstream of or within synapse organization. Located in several cellular components, including dendritic shaft; inhibitory synapse; and postsynaptic membrane. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human NLGN2 (neuroligin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 65.6), Uterus (RPKM 37.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55042175..55056578, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54544461..54557854, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56431586..56444847, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
Title: Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
these data indicate that NLGs are SNX27-retromer cargoes and suggest that SNX27-retromer controls inhibitory synapse number, at least in part through trafficking of NLG2.
Title: Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number.
Results showed that in pyramidal and interneurons, neuroligin 1 and neuroligin 3 were involved in excitatory synapse formation, and neuroligin 2 in GABAergic synapse formation.
Title: Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons.
Our study indicates that the incision-induced interaction between neuroligin 2 and PSD-95 and subsequent synaptic targeting of GluR1 in ipsilateral dorsal horns contribute to postoperative pain hypersensitivity.
Title: Increased Neuroligin 2 Levels in the Postsynaptic Membrane in Spinal Dorsal Horn may Contribute to Postoperative Pain.
e found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses.
Title: Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.
Findings highlight peripuberty as a period that is highly vulnerable to stress, leading to the development of attention deficits and a dysfunction in the prefrontal cortex GABAergic system and NLGN-2 expression
Title: Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress.
Studied the effect of clonal overexpression of NL3 and NL2 in neurons of the rat cerebral cortex in vivo after in utero electroporation
Title: In vivo clonal overexpression of neuroligin 3 and neuroligin 2 in neurons of the rat cerebral cortex: Differential effects on GABAergic synapses and neuronal migration.
Results highlight hippocampal NLGN-2 as a key molecular substrate regulating social behaviors and underscore NLGNs as promising targets for the development of novel drugs for the treatment of dysfunctional social behaviors
Title: Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression.
Our data showed unexpected upregulation and pronociceptive effects of the "inhibitory" NL2 in neuropathic pain
Title: Unexpected association of the "inhibitory" neuroligin 2 with excitatory PSD95 in neuropathic pain.
Data suggest nlgn2 in the hippocampus to be strongly implicated in maintaining the E/I balance in the brain and thereby modulating social and emotional behavior.
Title: Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neurexin family protein binding	IEA Inferred from Electronic Annotation more info
enables neurexin family protein binding	ISO Inferred from Sequence Orthology more info
enables neurexin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in gephyrin clustering involved in postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gephyrin clustering involved in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in gephyrin clustering involved in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in gephyrin clustering involved in postsynaptic density assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in inhibitory synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in insulin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in jump response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory exploration behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter-gated ion channel clustering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurotransmitter-gated ion channel clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inhibitory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic vesicle clustering	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of t-SNARE clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic density protein 95 clustering	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic density protein 95 clustering	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density protein 95 clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic membrane assembly	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic specialization assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in presynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic membrane assembly	IEA Inferred from Electronic Annotation more info
involved_in presynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of AMPA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of nervous system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of respiratory gaseous exchange by nervous system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory gaseous exchange by nervous system process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dopaminergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glycinergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neuroligin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.