TRIML1 tripartite motif family like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIML1provided by HGNC
Official Full Name: tripartite motif family like 1provided by HGNC
Primary source: HGNC:HGNC:26698
See related: Ensembl:ENSG00000184108 MIM:620979; AllianceGenome:HGNC:26698
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNF209
Summary: The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]
Expression: Restricted expression toward testis (RPKM 5.0) See more
Orthologs: mouse all
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Genomic context

Location:: 4q35.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (188137229..188150767)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (191484912..191498442)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (189060595..189068897)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This paper describes the mouse ortholog of the human TRIML1 gene.
Title: Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:486656

D4S2921 (e-PCR), detects polymorphism
- UniSTS:67174

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase TRIML1

Names: RING finger protein 209; RING-type E3 ubiquitin transferase TRIML1

NP_848651.2

EC 2.3.2.27

XP_006714270.1

EC 2.3.2.27

XP_011530221.1

EC 2.3.2.27

XP_024309796.1

EC 2.3.2.27

XP_054205900.1

EC 2.3.2.27

XP_054205901.1

EC 2.3.2.27

XP_054205902.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051631.1 RefSeqGene

Range

6253..14555

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_178556.5 → NP_848651.2 probable E3 ubiquitin-protein ligase TRIML1

See identical proteins and their annotated locations for NP_848651.2

Status: REVIEWED

Source sequence(s)

AK093499, BC015684, DB058735

Consensus CDS

CCDS3851.1

UniProtKB/Swiss-Prot

Q8N9V2, Q96BE5

Related

ENSP00000327738.3, ENST00000332517.4

Conserved Domains (3) summary

pfam10249
Location:130 → 184

NDUFB10; NADH-ubiquinone oxidoreductase subunit 10

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cd13733
Location:287 → 462

SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

188137229..188150767

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024454028.1 → XP_024309796.1 probable E3 ubiquitin-protein ligase TRIML1 isoform X2

Conserved Domains (1) summary

cd13733
Location:190 → 365

SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
XM_011531919.2 → XP_011530221.1 probable E3 ubiquitin-protein ligase TRIML1 isoform X2

Conserved Domains (1) summary

cd13733
Location:190 → 365

SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
XM_006714207.4 → XP_006714270.1 probable E3 ubiquitin-protein ligase TRIML1 isoform X1

Conserved Domains (3) summary

pfam10249
Location:130 → 184

NDUFB10; NADH-ubiquinone oxidoreductase subunit 10

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cl02614
Location:287 → 414

SPRY; SPRY domain

RNA

XR_001741216.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

191484912..191498442

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054349927.1 → XP_054205902.1 probable E3 ubiquitin-protein ligase TRIML1 isoform X2
XM_054349926.1 → XP_054205901.1 probable E3 ubiquitin-protein ligase TRIML1 isoform X2
XM_054349925.1 → XP_054205900.1 probable E3 ubiquitin-protein ligase TRIML1 isoform X1