Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcns3provided by RGD
Official Full Name: potassium voltage-gated channel, modifier subfamily S, member 3provided by RGD
Primary source: RGD:621527
See related: EnsemblRapid:ENSRNOG00000004899 AllianceGenome:RGD:621527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv9.3
Summary: Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNS3 (potassium voltage-gated channel modifier subfamily S member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 121.7), Brain (RPKM 41.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q15

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (39527410..39584105, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (33808314..33865018, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (36764040..36819810, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

different Kv9.3/Kv2.1 ratios could have physiological implications in lung and brain during post-natal development, and that diet composition and selective tissue-specific insulin regulation modulate the expression of Kv2.1 and Kv9.3.
Title: Different Kv2.1/Kv9.3 heteromer expression during brain and lung post-natal development in the rat.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:236805 (e-PCR)
- UniSTS:236805

D12Ertd137e (e-PCR), detects polymorphism
- UniSTS:167082

D6Rat84 (e-PCR)
- UniSTS:118997

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: delayed-rectifier potassium channel regulatory subunit KCNS3; potassium voltage-gated channel subfamily S member 3

Names: Shab-related delayed-rectifier K+ channel (Kv9.3); delayed-rectifier K(+) channel alpha subunit 3; delayed-rectifier potassium channel subunit Kv9.3; potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; voltage-gated potassium channel subunit Kv9.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389230.1 → NP_001376159.1 delayed-rectifier potassium channel regulatory subunit KCNS3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

O54900, O88759

UniProtKB/TrEMBL

A6HAP0

Related

ENSRNOP00000105842.1, ENSRNOT00000152198.1

Conserved Domains (2) summary

cd18428
Location:15 → 122

BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)

pfam00520
Location:184 → 417

Ion_trans; Ion transport protein
NM_031778.3 → NP_113966.2 delayed-rectifier potassium channel regulatory subunit KCNS3

See identical proteins and their annotated locations for NP_113966.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

O54900, O88759

UniProtKB/TrEMBL

A6HAP0

Related

ENSRNOP00000102174.1, ENSRNOT00000133371.1

Conserved Domains (2) summary

cd18428
Location:15 → 122

BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)

pfam00520
Location:184 → 417

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

39527410..39584105 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112998.2 → XP_038968926.1 potassium voltage-gated channel subfamily S member 3 isoform X1

UniProtKB/Swiss-Prot

O54900, O88759

UniProtKB/TrEMBL

A6HAP0

Conserved Domains (2) summary

cd18428
Location:15 → 122

BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)

pfam00520
Location:184 → 417

Ion_trans; Ion transport protein
XM_039112997.2 → XP_038968925.1 potassium voltage-gated channel subfamily S member 3 isoform X1

UniProtKB/Swiss-Prot

O54900, O88759

UniProtKB/TrEMBL

A6HAP0

Related

ENSRNOP00000080054.1, ENSRNOT00000108088.2

Conserved Domains (2) summary

cd18428
Location:15 → 122

BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)

pfam00520
Location:184 → 417

Ion_trans; Ion transport protein