U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    STX11 syntaxin 11 [ Homo sapiens (human) ]

    Gene ID: 8676, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    STX11provided by HGNC
    Official Full Name
    syntaxin 11provided by HGNC
    Primary source
    HGNC:HGNC:11429
    See related
    Ensembl:ENSG00000135604 MIM:605014; AllianceGenome:HGNC:11429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FHL4; HLH4; HPLH4
    Summary
    This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 13.4), fat (RPKM 5.2) and 8 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See STX11 in Genome Data Viewer
    Location:
    6q24.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (144139963..144191939)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (145332677..145384568)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (144471654..144513076)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378036 Neighboring gene MPRA-validated peak6182 silencer Neighboring gene mitochondrial ribosomal protein L42 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:144507610-144508110 Neighboring gene Sharpr-MPRA regulatory region 5218 Neighboring gene TPT1 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:144537315-144537779 Neighboring gene tRNA-Leu (anticodon TAA) 1-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules. Dabrazhynetskaya A, et al. J Cell Mol Med, 2012 Jan. PMID 21342435, Free PMC Article
    2. Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection. Ganesan S, et al. mBio, 2023 Feb 28. PMID 36728431, Free PMC Article
    3. Unusual functional manifestations of a novel STX11 frameshift mutation in two infants with familial hemophagocytic lymphohistiocytosis type 4 (FHL4). Macartney CA, et al. Pediatr Blood Cancer, 2011 Apr. PMID 21298754
    4. STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America. Marsh RA, et al. Pediatr Blood Cancer, 2010 Jul 15. PMID 20486178
    5. Novel syntaxin 11 gene (STX11) mutation in three Argentinean patients with hemophagocytic lymphohistiocytosis. Danielian S, et al. J Clin Immunol, 2010 Mar. PMID 19967551, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.
      Title: Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.
    2. Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
      Title: Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
    3. Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection.
      Title: Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection.
    4. Familial Hemophagocytic Lymphohistiocytosis With Heterozygous STX11 and Homozygous UNC13D Mutations Diagnosed in the Neonatal Period.
      Title: Familial Hemophagocytic Lymphohistiocytosis With Heterozygous STX11 and Homozygous UNC13D Mutations Diagnosed in the Neonatal Period.
    5. Spectrum mutations of PRF1, UNC13D, STX11, and STXBP2 genes in Vietnamese patients with hemophagocytic lymphohistiocytosis.
      Title: Spectrum mutations of PRF1, UNC13D, STX11, and STXBP2 genes in Vietnamese patients with hemophagocytic lymphohistiocytosis.
    6. STX11-deficient familial hemophagocytic lymphohistiocytosis type 4 is associated with self-resolving flares and a milder clinical course.
      Title: STX11-deficient familial hemophagocytic lymphohistiocytosis type 4 is associated with self-resolving flares and a milder clinical course.
    7. Data suggest that acylation of SNAP23 (synaptosome associated protein 23) and STX11 (syntaxin-11) regulates exocytosis in platelets; maintaining acylation states of SNAP23 and STX11 is important for platelet function.
      Title: Dynamic cycling of t-SNARE acylation regulates platelet exocytosis.
    8. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion.
      Title: Down Regulation of the Munc18b-syntaxin-11 Complex and β1-tubulin Impairs Secretion and Spreading in Neonatal Platelets.
    9. The results suggest that STX11 plays an important role in the pathogenesis of Peripheral T-cell lymphomas and they may contribute to the future development of new drugs for the treatment of Peripheral T-cell lymphomas.
      Title: STX11 functions as a novel tumor suppressor gene in peripheral T-cell lymphomas.
    10. a pivotal role for S-acylation in the function of syntaxin 11 in NK cells
      Title: Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Familial hemophagocytic lymphohistiocytosis 4
    MedGen: C1863728 OMIM: 603552 GeneReviews: Not available
    		Compare labs

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    syntaxin-11

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007613.1 RefSeqGene

      Range
      5001..46423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_113

    mRNA and Protein(s)

    1. NM_003764.4 → NP_003755.2  syntaxin-11

      Status: REVIEWED

      Source sequence(s)
      AI791689, AL135917, BC033519, BF941242, BM150302, BQ030324, CR739089
      Consensus CDS
      CCDS5205.1
      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6
      Related
      ENSP00000356540.4, ENST00000367568.5
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin; Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      144139963..144191939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419436.1 → XP_047275392.1  syntaxin-11 isoform X1

    2. XM_011536213.3 → XP_011534515.1  syntaxin-11 isoform X1

      Conserved Domains (3) summary
      cd00179
      Location:67 → 219
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15878
      Location:229 → 291
      SNARE_syntaxin11; SNARE motif of syntaxin 11
      pfam00804
      Location:67 → 264
      Syntaxin; Syntaxin

    3. XM_047419439.1 → XP_047275395.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    4. XM_011536218.3 → XP_011534520.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin; Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    5. XM_047419440.1 → XP_047275396.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    6. XM_047419441.1 → XP_047275397.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    7. XM_047419437.1 → XP_047275393.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    8. XM_047419438.1 → XP_047275394.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    9. XM_011536214.3 → XP_011534516.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6
      Related
      ENSP00000513678.1, ENST00000698355.1
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin; Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    10. XM_011536217.3 → XP_011534519.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6
      Related
      ENSP00000513680.1, ENST00000698357.1
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin; Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      145332677..145384568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356637.1 → XP_054212612.1  syntaxin-11 isoform X1

    2. XM_054356644.1 → XP_054212619.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    3. XM_054356641.1 → XP_054212616.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    4. XM_054356642.1 → XP_054212617.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    5. XM_054356639.1 → XP_054212614.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    6. XM_054356640.1 → XP_054212615.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    7. XM_054356638.1 → XP_054212613.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6

    8. XM_054356643.1 → XP_054212618.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      E1P598, O75378, O75558, O95148, Q5TCL6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75558.1 GenPept UniProtKB/Swiss-Prot:O75558

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools