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    TCL1A TCL1 family AKT coactivator A [ Homo sapiens (human) ]

    Gene ID: 8115, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TCL1Aprovided by HGNC
    Official Full Name
    TCL1 family AKT coactivator Aprovided by HGNC
    Primary source
    HGNC:HGNC:11648
    See related
    Ensembl:ENSG00000100721 MIM:186960; AllianceGenome:HGNC:11648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCL1
    Summary
    Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
    Expression
    Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCL1A in Genome Data Viewer
    Location:
    14q32.13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95709947..95714125, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (89941532..89945710, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96176284..96180462, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene TCL1 family AKT coactivator B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8972 Neighboring gene uncharacterized LOC124903373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6050 Neighboring gene uncharacterized LOC107984703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8980 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96237254-96237437 Neighboring gene uncharacterized LOC105370644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. Herling M, et al. Blood, 2008 Jan 1. PMID 17890451, Free PMC Article
    2. TCL1: a shared tumor-associated antigen for immunotherapy against B-cell lymphomas. Weng J, et al. Blood, 2012 Aug 23. PMID 22645177, Free PMC Article
    3. Recurrent breakpoints in 14q32.13/TCL1A region in mature B-cell neoplasms with villous lymphocytes. Urbankova H, et al. Leuk Lymphoma, 2012 Dec. PMID 22553924
    4. Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia. Sivina M, et al. Leukemia, 2012 Aug. PMID 22460735
    5. Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression. Liu M, et al. Breast Cancer Res, 2012 Mar 9. PMID 22405131, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation.
      Title: B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation.
    2. Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
      Title: Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
    3. TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.
      Title: TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.
    4. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
      Title: Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
    5. TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.
      Title: TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.
    6. Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.
      Title: Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.
    7. Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
      Title: Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
    8. TCL1A also acts as a transcriptional coregulator with NF-kappaB p65
      Title: TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence.
    9. TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.
      Title: TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.
    10. Combination of T-cell lymphoma-1 protein (TCL1)-overexpression and damaging ataxia telangiectasia mutated protein (ATM) functionally synergistically contribute to T-cell prolymphocytic leukemia (T-PLL) specific phenotype of impaired DNA damage processing.
      Title: Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
    Submit: New GeneRIF Correction See all GeneRIFs (69)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    T-cell leukemia/lymphoma protein 1A
    Names
    T cell leukemia/lymphoma 1A
    T-cell lymphoma-1
    oncogene TCL-1
    oncogene TCL1
    protein p14 TCL1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098725.2 → NP_001092195.1  T-cell leukemia/lymphoma protein 1A

      See identical proteins and their annotated locations for NP_001092195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL139020, BC014024, BG718395, X82240
      Consensus CDS
      CCDS9941.1
      UniProtKB/Swiss-Prot
      P56279, Q6IBK7
      Related
      ENSP00000451506.1, ENST00000554012.5
      Conserved Domains (1) summary
      pfam01840
      Location:1 → 112
      TCL1_MTCP1; TCL1/MTCP1 family

    2. NM_021966.3 → NP_068801.1  T-cell leukemia/lymphoma protein 1A

      See identical proteins and their annotated locations for NP_068801.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AL139020, BC014024, BG718395, X82240
      Consensus CDS
      CCDS9941.1
      UniProtKB/Swiss-Prot
      P56279, Q6IBK7
      Related
      ENSP00000385036.1, ENST00000402399.6
      Conserved Domains (1) summary
      pfam01840
      Location:1 → 112
      TCL1_MTCP1; TCL1/MTCP1 family

    RNA

    1. NR_049726.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL139020, BU602054, X82240

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      95709947..95714125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      89941532..89945710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56279.1 GenPept UniProtKB/Swiss-Prot:P56279

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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