PLPP6 phospholipid phosphatase 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLPP6provided by HGNC
Official Full Name: phospholipid phosphatase 6provided by HGNC
Primary source: HGNC:HGNC:23682
See related: Ensembl:ENSG00000205808 MIM:611666; AllianceGenome:HGNC:23682
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PDP1; PSDP; LPRP-B; PA-PSP; PPAPDC2; bA6J24.6
Summary: Enables isoprenoid diphosphate phosphatase activity and phosphatase activity. Involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of neutrophil activation. Located in endoplasmic reticulum membrane and nuclear membrane. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: mouse all
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Genomic context

Location:: 9p24.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (4662294..4665258)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (4665968..4668932)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (4662294..4665258)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that polyisoprenyl diphosphate phosphatase 1 (PDP1) serves an integral signaling role in neutrophil proinflammatory responses and as a target for counter-regulatory mediators.
Title: 15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1.
PDP1 can serve as a new checkpoint for polyisoprenyl phosphate remodeling during cell activation.[PDP1]
Title: Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate.
PDP1/PPAPDC2 is a functional isoprenoid diphosphate phosphatase.
Title: Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.
findings indicate that PPAPDC2 in human PMN is the first lipid phosphate phosphohydrolase identified for PSDP; regulation of this activity of the enzyme may have important roles for PMN activation in innate immunity
Title: Identification and functional characterization of a presqualene diphosphate phosphatase.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hydrolase activity	TAS Traceable Author Statement more info
enables isoprenoid diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	TAS Traceable Author Statement more info
involved_in farnesyl diphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in geranyl diphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in geranylgeranyl diphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neutrophil activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein prenylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

Names: PPAP2 domain-containing protein 2; lipid phosphatase-related protein-B; phosphatidic acid phosphatase type 2 domain containing 2; phosphatidic acid phosphatase type 2 domain-containing protein 2; polyisoprenoid diphosphate phosphatase type 1; presqualene diphosphate phosphatase; type 1 polyisoprenoid diphosphate phosphatase

NP_982278.3

EC 3.6.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_203453.5 → NP_982278.3 polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

See identical proteins and their annotated locations for NP_982278.3

Status: VALIDATED

Source sequence(s)

AK128369, BC036833, DA416947

Consensus CDS

CCDS34981.1

UniProtKB/Swiss-Prot

B3KY05, Q5JVJ6, Q8IY26, Q8NCK9

Related

ENSP00000371307.2, ENST00000381883.5

Conserved Domains (2) summary

COG0671
Location:208 → 292

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03391
Location:118 → 276

PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...