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    LOC5666907 uncharacterized LOC5666907 [ Anopheles gambiae (African malaria mosquito) ]

    Gene ID: 5666907, updated on 22-Jun-2024

    Summary

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    Gene symbol
    LOC5666907
    Gene description
    uncharacterized LOC5666907
    See related
    VectorBase:AGAMI1_000379
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Anopheles gambiae
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles
    Also known as
    APL1C
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    Genomic context

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    See LOC5666907 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_12 current idAnoGambNW_F1_1 (GCF_943734735.2) 2 NC_064601.1 (110023391..110033892, complement)

    Chromosome 2 - NC_064601.1Genomic Context describing neighboring genes Neighboring gene protein scabrous Neighboring gene breast cancer type 2 susceptibility protein homolog Neighboring gene WD repeat-containing protein on Y chromosome Neighboring gene leucine-rich repeat-containing protein 69 Neighboring gene platelet glycoprotein V

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_064601.1 Chromosome 2 Reference idAnoGambNW_F1_1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene copy number and function of the APL1 immune factor changed during Anopheles evolution. Mitri C, et al. Parasit Vectors, 2020 Jan 13. PMID 31931885, Free PMC Article
    2. Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1. Williams M, et al. PLoS One, 2015. PMID 25775123, Free PMC Article
    3. Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites. Povelones M, et al. Science, 2009 Apr 10. PMID 19264986, Free PMC Article
    4. A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae. Baxter RH, et al. Proc Natl Acad Sci U S A, 2010 Sep 28. PMID 20826443, Free PMC Article
    5. Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Fraiture M, et al. Cell Host Microbe, 2009 Mar 19. PMID 19286136

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APL1 gene promotes longevity by conferring protection from or tolerance to an effect of bacterial pathology
      Title: Gene copy number and function of the APL1 immune factor changed during Anopheles evolution.
    2. Full-length APL1A1 and APL1B form a stable complex with LRIM1. These results support a model in which APL1A1, APL1B and APL1C can all form an extended, flexible heterodimer with LRIM1, providing a repertoire of functional innate immune complexes to protect A. gambiae from a diverse array of pathogens.
      Title: Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1.
    3. a cleaved form of TEP1 may act as a convertase for activation of other TEP1 molecules and that the LRIM1/APL1C heterodimer regulates formation of this TEP1 convertase.
      Title: A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae.
    4. The authors show that LRIM1 and APL1 are required for binding of TEP1 to parasites.
      Title: Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium.
    5. study shows 2 proteins that antagonize malaria infections, LRIM1 & APL1C, circulate in hemolymph as a complex which interacts with complement C3-like protein, TEP1, promoting its cleavage or stabilization & localization on Plasmodium berghei.
      Title: Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein LOC5666907
    Names
    AGAP007033-PA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_943734735.2-RS_2023_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference idAnoGambNW_F1_1 Primary Assembly

    Genomic

    1. NC_064601.1 Reference idAnoGambNW_F1_1 Primary Assembly

      Range
      110023391..110033892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_061640541.1 → XP_061496525.1  uncharacterized protein LOC5666907

    Nucleotide Protein Strain
    Heading Accession and Version

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