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    PF3D7_1209500.1 cGMP-specific 3',5'-cyclic phosphodiesterase alpha [ Plasmodium falciparum 3D7 ]

    Gene ID: 811148, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1209500.1
    Gene description
    cGMP-specific 3',5'-cyclic phosphodiesterase alpha
    Locus tag
    PF3D7_1209500.1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Old locus tag
    PF3D7_1209500.2
    Orthologs
    all
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    Genomic context

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    See PF3D7_1209500.1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    3
    Sequence:
    Chromosome: 12; NC_037284.1 (439711..442858)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene telomere repeat-binding zinc finger protein Neighboring gene cytosolic iron-sulfur protein assembly protein 1, putative Neighboring gene porphobilinogen deaminase Neighboring gene conserved protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum. Yuasa K, et al. Biochem J, 2005 Nov 15. PMID 16038615, Free PMC Article
    2. Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein. Wentzinger L, et al. Int J Parasitol, 2008 Dec. PMID 18590734
    3. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cGMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cGMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cGMP-specific 3',5'-cyclic phosphodiesterase alpha
    XP_001350504.2
    XP_024329151.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      439711..442858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350468.2 → XP_001350504.2  cGMP-specific 3',5'-cyclic phosphodiesterase alpha [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350504.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      B3FEM4, B3FEM5, Q2V2M6, Q8I5V4
      UniProtKB/TrEMBL
      A0A024X4F6, W4J1F8, W7JKL8, W7KD30
      Conserved Domains (1) summary
      pfam00233
      Location:679 → 903
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_024473385.1 → XP_024329151.1  cGMP-specific 3',5'-cyclic phosphodiesterase alpha [Plasmodium falciparum 3D7]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024X4F6, A0A2I0BY19, W4J1F8, W7JKL8
      Conserved Domains (1) summary
      pfam00233
      Location:617 → 841
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version

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