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    PF3D7_1216700 perforin-like protein 2 [ Plasmodium falciparum 3D7 ]

    Gene ID: 811214, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1216700
    Gene description
    perforin-like protein 2
    Locus tag
    PF3D7_1216700
    See related
    PlasmoDB:PF3D7_1216700; VEuPathDB:PF3D7_1216700
    Gene type
    protein coding
    RNA name
    perforin-like protein 2
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1216700 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    1
    Sequence:
    Chromosome: 12; NC_037284.1 (663061..666282)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene male development gene 1 Neighboring gene cell traversal protein for ookinetes and sporozoites Neighboring gene tRNA-Pro Neighboring gene DNA-binding chaperone, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes. Wirth CC, et al. Cell Microbiol, 2014 May. PMID 24602217, Free PMC Article
    2. A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes. Deligianni E, et al. Cell Microbiol, 2013 Aug. PMID 23461714
    3. Plasmodium Perforin-Like Protein Pores on the Host Cell Membrane Contribute in Its Multistage Growth and Erythrocyte Senescence. Garg S, et al. Front Cell Infect Microbiol, 2020. PMID 32266171, Free PMC Article
    4. Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission. Singh P, et al. Proc Natl Acad Sci U S A, 2019 Aug 27. PMID 31413195, Free PMC Article
    5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables wide pore channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    perforin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      663061..666282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350534.1 → XP_001350570.1  perforin-like protein 2 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350570.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024V6F4, A0A024VPD9, A0A024W5Q8, A0A024X6Q6, A0A0L7KGV0, Q8I5P0, W4J2D7, W7FC51, W7FEN4, W7J924, W7KD85
      Conserved Domains (1) summary
      PTZ00482
      Location:369 → 1064
      PTZ00482; membrane-attack complex/perforin (MACPF) Superfamily; Provisional
    Nucleotide Protein
    Heading Accession and Version

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