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    PF3D7_1354500 adenylosuccinate synthetase [ Plasmodium falciparum 3D7 ]

    Gene ID: 814251, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1354500
    Gene description
    adenylosuccinate synthetase
    Locus tag
    PF3D7_1354500
    See related
    PlasmoDB:PF3D7_1354500; VEuPathDB:PF3D7_1354500
    Gene type
    protein coding
    RNA name
    adenylosuccinate synthetase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1354500 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    2
    Sequence:
    Chromosome: 13; NC_004331.3 (2174346..2175797)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene large subunit rRNA methyltransferase, putative Neighboring gene V-type proton ATPase 21 kDa proteolipid subunit, putative Neighboring gene 60S ribosomal protein L7-2, putative Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of cysteine 328 and cysteine 368 at the interface of Plasmodium falciparum adenylosuccinate synthetase. Mehrotra S, et al. Biochim Biophys Acta, 2012 Apr. PMID 22289630
    2. Unique kinetic mechanism of Plasmodium falciparum adenylosuccinate synthetase. Raman J, et al. Mol Biochem Parasitol, 2004 Nov. PMID 15500910
    3. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867
    4. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cysteines at the dimer interface of Plasmodium falciparum adenylosuccinate synthetase may be charged and exist as thiolate anion.
      Title: Mutational analysis of cysteine 328 and cysteine 368 at the interface of Plasmodium falciparum adenylosuccinate synthetase.
    2. kinetic evidence shows that unlike all other AdSS, Plasmodium falciparum AdSS (PfAdSS) has ordered substrate binding
      Title: Unique kinetic mechanism of Plasmodium falciparum adenylosuccinate synthetase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables adenylosuccinate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within AMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylosuccinate synthetase
    XP_001350257.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      2174346..2175797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350221.1 → XP_001350257.1  adenylosuccinate synthetase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350257.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8IDF6, Q9U8D3
      UniProtKB/TrEMBL
      A0A024VJ47, A0A024W310, A0A024WK07, A0A024X2L5, A0A0L1IFB7, A0A0L7KI77, W4IC42, W4J076, W7FRN5, W7JNK7, W7JS70
      Conserved Domains (1) summary
      PTZ00350
      Location:3 → 437
      PTZ00350; adenylosuccinate synthetase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IDF6.1

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