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    PF3D7_0206700 adenylosuccinate lyase [ Plasmodium falciparum 3D7 ]

    Gene ID: 812659, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0206700
    Gene description
    adenylosuccinate lyase
    Locus tag
    PF3D7_0206700
    See related
    PlasmoDB:PF3D7_0206700; VEuPathDB:PF3D7_0206700
    Gene type
    protein coding
    RNA name
    adenylosuccinate lyase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0206700 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_037280.1 (271594..273009)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene DNA-directed RNA polymerase III subunit RPC10, putative Neighboring gene merozoite surface protein 2 Neighboring gene merozoite surface protein 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum. Bulusu V, et al. Biochim Biophys Acta, 2009 Apr. PMID 19111634
    2. A network-based approach reveals novel invasion and Maurer's clefts-related proteins in Plasmodium falciparum. Das D, et al. Mol Omics, 2019 Dec 2. PMID 31631203
    3. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Science, 1998 Nov 6. PMID 9804551
    4. Identification of Plasmodium falciparum nuclear proteins by mass spectrometry and proposed protein annotation. Briquet S, et al. PLoS One, 2018. PMID 30379851, Free PMC Article
    5. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Oehring SC, et al. Genome Biol, 2012 Nov 26. PMID 23181666, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. detailed kinetic and catalytic mechanism of the recombinant His-tagged adenylosuccinate lyase from Plasmodium falciparum is presented
      Title: Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within purine nucleotide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    adenylosuccinate lyase
    XP_001349577.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      271594..273009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349541.1 → XP_001349577.1  adenylosuccinate lyase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349577.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024WEQ5, A0A024WX02, A0A024XET5, A0A0L1I5Y6, A0A0L7K7E9, A0A193PBN1, A0A193PCG6, A0A193PCH1, A0A193PD39, E1CD68, E1CD69, E1CDE8, E1CDI1, E1CDY9, O15918, Q7KWJ4, W4IPH4, W4J859, W7FLF5, W7G238, W7K251
      Conserved Domains (1) summary
      cd01598
      Location:25 → 452
      PurB; PurB_like adenylosuccinases (adenylosuccinate lyase, ASL)
    Nucleotide Protein
    Heading Accession and Version

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