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    PF3D7_0517300 serine/arginine-rich splicing factor 1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812988, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0517300
    Gene description
    serine/arginine-rich splicing factor 1
    Locus tag
    PF3D7_0517300
    See related
    PlasmoDB:PF3D7_0517300; VEuPathDB:PF3D7_0517300
    Gene type
    protein coding
    RNA name
    serine/arginine-rich splicing factor 1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0517300 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_004326.2 (724681..725751, complement)

    Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene FACT complex subunit SPT16, putative Neighboring gene UTP--glucose-1-phosphate uridylyltransferase, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004326.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An SR protein is essential for activating DNA repair in malaria parasites. Goyal M, et al. J Cell Sci, 2021 Aug 15. PMID 34291805, Free PMC Article
    2. The N-terminal RNA Recognition Motif of PfSR1 Confers Semi-specificity for Pyrimidines during RNA Recognition. Ganguly AK, et al. J Mol Biol, 2019 Feb 1. PMID 30500338
    3. PfSR1 controls alternative splicing and steady-state RNA levels in Plasmodium falciparum through preferential recognition of specific RNA motifs. Eshar S, et al. Mol Microbiol, 2015 Jun. PMID 25807998
    4. A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes. Eshar S, et al. Nucleic Acids Res, 2012 Oct. PMID 22885299, Free PMC Article
    5. Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite. Sinha A, et al. mBio, 2021 Apr 27. PMID 33906926, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004326.2 Reference assembly

      Range
      724681..725751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351694.2 → XP_001351730.2  serine/arginine-rich splicing factor 1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351730.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VC89, A0A024WF66, A0A024WV00, A0A024XD25, A0A0L0CY26, A0A0L1I6K9, Q8I3T5, W4ILR9, W4IVV4, W7F6F4, W7G003, W7JGZ2, W7K8X6
      Conserved Domains (2) summary
      cd12338
      Location:9 → 80
      RRM1_SRSF1_like; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
      cl17169
      Location:111 → 184
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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