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    PF3D7_0930300 merozoite surface protein 1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 813575, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0930300
    Gene description
    merozoite surface protein 1
    Locus tag
    PF3D7_0930300
    See related
    PlasmoDB:PF3D7_0930300; VEuPathDB:PF3D7_0930300
    Gene type
    protein coding
    RNA name
    merozoite surface protein 1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0930300 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    1
    Sequence:
    Chromosome: 9; NC_004330.2 (1201812..1206974)

    Chromosome 9 - NC_004330.2Genomic Context describing neighboring genes Neighboring gene heptatricopeptide repeat-containing protein, putative Neighboring gene leucine-rich repeat protein Neighboring gene zinc finger protein, putative Neighboring gene diacylglycerol kinase, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004330.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking. Gilson PR, et al. Mol Microbiol, 2008 Apr. PMID 18333885
    2. Genetic analysis of the merozoite surface protein-1 block 2 allelic types in Plasmodium falciparum clinical isolates from Lao PDR. Khaminsou N, et al. Malar J, 2011 Dec 17. PMID 22177111, Free PMC Article
    3. Polymorphism of the merozoite surface protein-1 block 2 region in Plasmodium falciparum isolates from Mauritania. Ahmedou Salem MS, et al. Malar J, 2014 Jan 23. PMID 24456636, Free PMC Article
    4. Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth. Child MA, et al. Mol Microbiol, 2010 Oct. PMID 20735778, Free PMC Article
    5. C-terminal polymorphism of Plasmodium falciparium merozoite surface protein-1 (MSP-1) from Tak Province, Thailand. Viputtigul K, et al. Southeast Asian J Trop Med Public Health, 2013 Jan. PMID 23682431

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2 and multiplicity of infections in western Ethiopia following effective malaria interventions.
      Title: Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2 and multiplicity of infections in western Ethiopia following effective malaria interventions.
    2. Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated from symptomatic and asymptomatic malaria subjects in the South of Benin.
      Title: Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated from symptomatic and asymptomatic malaria subjects in the South of Benin.
    3. Detection of high frequency of MAD20 allelic variants of Plasmodium falciparum merozoite surface protein 1 gene from Adama and its surroundings, Oromia, Ethiopia.
      Title: Detection of high frequency of MAD20 allelic variants of Plasmodium falciparum merozoite surface protein 1 gene from Adama and its surroundings, Oromia, Ethiopia.
    4. Diversity and natural selection of Merozoite surface Protein-1 in three species of human malaria parasites: Contribution from South-East Asian isolates.
      Title: Diversity and natural selection of Merozoite surface Protein-1 in three species of human malaria parasites: Contribution from South-East Asian isolates.
    5. Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal.
      Title: Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal.
    6. The block 2 of msp-1 gene was found to be highly polymorphic, and overall allelic distribution showed that RO33 was the dominant allele (63%), followed by MAD20 (29%) and K1 (8%) alleles. However, an extensive diversity (9 alleles and 4 genotypes) and 6-10 repeat regions exclusively of R2 type were observed in glurp
      Title: Molecular characterization of Plasmodium falciparum in Arunachal Pradesh from Northeast India based on merozoite surface protein 1 & glutamate-rich protein.
    7. In northern India, extensive diversity was found in msp1 alleles with predominantly RO33 alleles.
      Title: Genetic diversity of Plasmodium falciparum merozoite surface protein-1 (block 2), glutamate-rich protein and sexual stage antigen Pfs25 from Chandigarh, North India.
    8. It is a vaccine candidate genes.
      Title: Isolation and Characterization of Vaccine Candidate Genes Including CSP and MSP1 in Plasmodium yoelii.
    9. peripheral merozoite surface proteins MSP3, MSP6, MSPDBL1, MSPDBL2, and MSP7 bind directly to MSP1, but independently of each other, to form multiple forms of the MSP1 complex on the parasite surface.
      Title: Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes.
    10. The authors show that SUB1-mediated processing of MSP1 is important for parasite viability, the processing modifies the secondary structure of MSP1 and activates its capacity to bind spectrin.
      Title: Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables host cell surface binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exit from host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular vesicle HDA PubMed 
    located_in food vacuole HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    merozoite surface protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004330.2 Reference assembly

      Range
      1201812..1206974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001352134.1 → XP_001352170.1  merozoite surface protein 1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001352170.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8I0U8
      UniProtKB/TrEMBL
      Q25922, W7KFP9
      Conserved Domains (4) summary
      TIGR01612
      Location:221 → 527
      235kDa-fam; reticulocyte binding/rhoptry protein
      pfam07462
      Location:981 → 1536
      MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
      pfam12946
      Location:1612 → 1648
      EGF_MSP1_1; MSP1 EGF domain 1
      pfam12947
      Location:1655 → 1698
      EGF_3; EGF domain
    Nucleotide Protein
    Heading Accession and Version

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