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    COS7 Cos7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COS7
    Official Full Name
    Cos7p
    Primary source
    SGD:S000002407
    Locus tag
    YDL248W
    See related
    AllianceGenome:SGD:S000002407; FungiDB:YDL248W; VEuPathDB:YDL248W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cargo receptor activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in fungal-type vacuole and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COS7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1802..2953)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene alpha-glucoside permease Neighboring gene L-iditol 2-dehydrogenase SOR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdc1 and the vacuole coordinately regulate Mn2+ homeostasis in the yeast Saccharomyces cerevisiae. Paidhungat M, et al. Genetics, 1998 Apr. PMID 9560393, Free PMC Article
    2. ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. Spode I, et al. J Mol Biol, 2002 May 31. PMID 12051917
    3. An evolutionary scenario for one of the largest yeast gene families. Despons L, et al. Trends Genet, 2006 Jan. PMID 16269202
    4. A family of tetraspans organizes cargo for sorting into multivesicular bodies. MacDonald C, et al. Dev Cell, 2015 May 4. PMID 25942624, Free PMC Article
    5. The proteome of Saccharomyces cerevisiae mitochondria. Sickmann A, et al. Proc Natl Acad Sci U S A, 2003 Nov 11. PMID 14576278, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cargo receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Cos7p
    NP_010033.1
    • Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1802..2953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180308.1 → NP_010033.1  TPA: Cos7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRA9, Q07788
      UniProtKB/TrEMBL
      B3LHC2
      Conserved Domains (1) summary
      pfam00674
      Location:261 → 353
      DUP; DUP family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07788.1

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