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    LRRC61 leucine rich repeat containing 61 [ Homo sapiens (human) ]

    Gene ID: 65999, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LRRC61provided by HGNC
    Official Full Name
    leucine rich repeat containing 61provided by HGNC
    Primary source
    HGNC:HGNC:21704
    See related
    Ensembl:ENSG00000127399 AllianceGenome:HGNC:21704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPC295
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 5.1), adrenal (RPKM 4.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC61 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150309499..150338156)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151487758..151516408)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150006588..150035245)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene actin related protein 3C Neighboring gene uncharacterized LOC124901772 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:149697909-149698096 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149721691-149722215 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149728774-149729275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149732655-149733170 Neighboring gene uncharacterized LOC100134040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149745856-149746490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149746491-149747124 Neighboring gene Sharpr-MPRA regulatory region 3139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149917438-149917972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149917973-149918507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149966003-149966503 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149976749-149977333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149983589-149984090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149984091-149984590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26822 Neighboring gene Sharpr-MPRA regulatory region 1750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18774 Neighboring gene uncharacterized LOC107986858 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:150044724-150044956 Neighboring gene zinc finger BED-type containing 10, pseudogene Neighboring gene retinoic acid receptor responder 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article
    2. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
    3. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
    4. Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Piette BL, et al. Mol Cell, 2021 Jun 17. PMID 33957083
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3036, FLJ22216, FLJ31392

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142928.2 → NP_001136400.1  leucine-rich repeat-containing protein 61

      See identical proteins and their annotated locations for NP_001136400.1

      Status: VALIDATED

      Source sequence(s)
      AC005586, AW444958
      Consensus CDS
      CCDS5901.1
      UniProtKB/Swiss-Prot
      B3KUW0, D3DWY8, Q9BV99
      UniProtKB/TrEMBL
      A0A090N7W5, B3KSM2
      Related
      ENSP00000352642.4, ENST00000359623.9
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:58 → 165
      LRR_9; Leucine-rich repeat

    2. NM_001363433.1 → NP_001350362.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      BG758667, BM126106, BM455442, DA936889, DA949948, HY253453
      Consensus CDS
      CCDS5901.1
      UniProtKB/Swiss-Prot
      B3KUW0, D3DWY8, Q9BV99
      UniProtKB/TrEMBL
      A0A090N7W5, B3KSM2
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:58 → 165
      LRR_9; Leucine-rich repeat

    3. NM_001363434.1 → NP_001350363.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      AC005586, AK098061, BM126106
      Consensus CDS
      CCDS5901.1
      UniProtKB/Swiss-Prot
      B3KUW0, D3DWY8, Q9BV99
      UniProtKB/TrEMBL
      A0A090N7W5, B3KSM2
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:58 → 165
      LRR_9; Leucine-rich repeat

    4. NM_023942.3 → NP_076431.1  leucine-rich repeat-containing protein 61

      See identical proteins and their annotated locations for NP_076431.1

      Status: VALIDATED

      Source sequence(s)
      AC005586, AW444958
      Consensus CDS
      CCDS5901.1
      UniProtKB/Swiss-Prot
      B3KUW0, D3DWY8, Q9BV99
      UniProtKB/TrEMBL
      A0A090N7W5, B3KSM2
      Related
      ENSP00000339047.6, ENST00000323078.7
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:58 → 165
      LRR_9; Leucine-rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      150309499..150338156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151487758..151516408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BV99.1 GenPept UniProtKB/Swiss-Prot:Q9BV99

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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