Gtpbp1 GTP binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtpbp1provided by MGI
Official Full Name: GTP binding protein 1provided by MGI
Primary source: MGI:MGI:109443
See related: Ensembl:ENSMUSG00000042535 AllianceGenome:MGI:109443
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GP-1; Gtpbp
Summary: Predicted to enable GTPase activity and nucleic acid binding activity. Predicted to be involved in GTP metabolic process; positive regulation of mRNA catabolic process; and translation. Predicted to be located in cytosol. Predicted to be part of cytoplasmic exosome (RNase complex). Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human GTPBP1 (GTP binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 30.9), spleen adult (RPKM 20.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.85 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79574202..79605680)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79690001..79721479)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling.
Title: Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW045683 (e-PCR)
- UniSTS:165942

RH125391 (e-PCR)
- UniSTS:162213

RH127153 (e-PCR)
- UniSTS:209112

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-aminoacyl-tRNA binding	IEA Inferred from Electronic Annotation more info
enables alpha-aminoacyl-tRNA binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic translation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytoplasmic exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic exosome (RNase complex)	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GTP-binding protein 1

Names: G-protein 1; GP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013818.2 → NP_038846.2 GTP-binding protein 1

See identical proteins and their annotated locations for NP_038846.2

Status: VALIDATED

Source sequence(s)

BC046228

Consensus CDS

CCDS27648.1

UniProtKB/Swiss-Prot

O08582, Q3UD96, Q3UGW6, Q545R1, Q80ZY5

Related

ENSMUSP00000043575.9, ENSMUST00000046463.10

Conserved Domains (4) summary

cd04165
Location:162 → 386

GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2

COG5258
Location:48 → 574

GTPBP1; GTPase [General function prediction only]

cd03694
Location:395 → 481

GTPBP_II; Domain II of the GTPBP family of GTP binding proteins

cd03708
Location:487 → 573

GTPBP_III; Domain III of the GP-1 family of GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79574202..79605680

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520450.2 → XP_006520513.1 GTP-binding protein 1 isoform X2

Conserved Domains (2) summary

cd04165
Location:50 → 274

GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2

COG5258
Location:1 → 462

GTPBP1; GTPase [General function prediction only]
XM_036159161.1 → XP_036015054.1 GTP-binding protein 1 isoform X1

Conserved Domains (2) summary

cd04165
Location:81 → 305

GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2

COG5258
Location:1 → 493

GTPBP1; GTPase [General function prediction only]