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    CLEC7A C-type lectin domain containing 7A [ Homo sapiens (human) ]

    Gene ID: 64581, updated on 10-Dec-2024

    Summary

    Official Symbol
    CLEC7Aprovided by HGNC
    Official Full Name
    C-type lectin domain containing 7Aprovided by HGNC
    Primary source
    HGNC:HGNC:14558
    See related
    Ensembl:ENSG00000172243 MIM:606264; AllianceGenome:HGNC:14558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12
    Summary
    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 22.1), bone marrow (RPKM 11.8) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CLEC7A in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10116777..10130304, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10003452..10016972, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10269376..10282798, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 1 member A Neighboring gene RN7SK pseudogene 161 Neighboring gene uncharacterized LOC105369655 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:10286337-10287157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:10305885-10306388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5959 Neighboring gene MPRA-validated peak1568 silencer Neighboring gene oxidized low density lipoprotein receptor 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:10331989-10333188 Neighboring gene transmembrane protein 52B Neighboring gene MPRA-validated peak1569 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4236 Neighboring gene GABARAPL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:10364713-10365255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4237 Neighboring gene GABA type A receptor associated protein like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Aspergillosis, susceptibility to
    MedGen: C3279774 OMIM: 614079 GeneReviews: Not available
    not available
    Familial chronic mucocutaneous candidiasis
    MedGen: C0341024 OMIM: 613108 GeneReviews: Not available
    not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables (1->3)-beta-D-glucan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables (1->3)-beta-D-glucan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables (1->3)-beta-D-glucan binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables (1->3)-beta-D-glucan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables MHC protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pattern recognition receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in antifungal innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carbohydrate mediated signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface pattern recognition receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to molecule of fungal origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to molecule of fungal origin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response to protozoan NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in detection of fungus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of molecule of fungal origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of molecule of fungal origin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detection of yeast ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagocytosis, recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagocytosis, recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T-helper 17 type immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of positive regulation of calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendritic cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-23 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lymphocyte activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of monocyte chemotactic protein-1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of respiratory burst IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to yeast ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stimulatory C-type lectin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-type lectin domain family 7 member A
    Names
    C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
    C-type lectin superfamily member 12
    DC-associated C-type lectin 1
    beta-glucan receptor
    dectin-1
    dendritic cell-associated C-type lectin-1
    lectin-like receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016291.1 RefSeqGene

      Range
      5001..18493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_179

    mRNA and Protein(s)

    1. NM_022570.5NP_072092.2  C-type lectin domain family 7 member A isoform b

      See identical proteins and their annotated locations for NP_072092.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a. Variant 2 has been alternatively referred to as variant 1 and isoform b has been alternatively referred to as beta in the literature.
      Source sequence(s)
      AF400596, AY009090, AY359002, CR749536, DA193873
      Consensus CDS
      CCDS8613.1
      UniProtKB/Swiss-Prot
      Q9BXN2
      UniProtKB/TrEMBL
      Q68D78
      Related
      ENSP00000266456.6, ENST00000353231.9
      Conserved Domains (3) summary
      cd03593
      Location:74197
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      PHA03097
      Location:33195
      PHA03097; C-type lectin-like protein; Provisional
      pfam08391
      Location:4067
      Ly49; Ly49-like protein, N-terminal region
    2. NM_197947.3NP_922938.1  C-type lectin domain family 7 member A isoform a

      See identical proteins and their annotated locations for NP_922938.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variant 1 has been alternatively referred to as variant 2 and isoform a has been alternatively referred to as alpha in the literature.
      Source sequence(s)
      AF400595, AY009090, AY359002, CR749536, DA193873
      Consensus CDS
      CCDS41753.1
      UniProtKB/Swiss-Prot
      B2R861, B7Z494, B7Z5A9, B7Z5B9, Q6IPS7, Q96D32, Q96DR9, Q96LD3, Q96PA4, Q96PA5, Q96PA6, Q96PA7, Q96PA8, Q9BXN2, Q9H1K3
      Related
      ENSP00000302569.8, ENST00000304084.13
      Conserved Domains (2) summary
      cd03593
      Location:120243
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:4067
      Ly49; Ly49-like protein, N-terminal region
    3. NM_197948.3NP_922939.1  C-type lectin domain family 7 member A isoform c

      See identical proteins and their annotated locations for NP_922939.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, which results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AF400597, AY009090, AY359002, CR749536, DA193873
      Consensus CDS
      CCDS41754.1
      UniProtKB/TrEMBL
      B7Z1Y8
      Related
      ENSP00000431461.1, ENST00000533022.5
      Conserved Domains (2) summary
      pfam08391
      Location:4067
      Ly49; Ly49-like protein, N-terminal region
      cl02432
      Location:120164
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    4. NM_197949.3NP_922940.1  C-type lectin domain family 7 member A isoform d

      See identical proteins and their annotated locations for NP_922940.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons, which results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform d) is shorter and contains a distinct C-terminus, compared to isoform a. Isoform d has been alternatively referred to as 'c' in the literature.
      Source sequence(s)
      AA361063, AY009090, AY026771, AY359002, CR749536, DA193873
      Consensus CDS
      CCDS53744.1
      UniProtKB/Swiss-Prot
      Q9BXN2
      UniProtKB/TrEMBL
      Q68D78
      Related
      ENSP00000298523.5, ENST00000298523.9
      Conserved Domains (2) summary
      pfam08391
      Location:4067
      Ly49; Ly49-like protein, N-terminal region
      cl02432
      Location:74118
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    5. NM_197950.3NP_922941.1  C-type lectin domain family 7 member A isoform e

      See identical proteins and their annotated locations for NP_922941.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform e) compared to isoform a.
      Source sequence(s)
      AF400599, AY009090, AY359002, CR749536, DA193873
      Consensus CDS
      CCDS8614.1
      UniProtKB/Swiss-Prot
      Q9BXN2
      UniProtKB/TrEMBL
      Q68D78
      Related
      ENSP00000379743.2, ENST00000396484.6
      Conserved Domains (1) summary
      cd03593
      Location:41164
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    6. NM_197954.3NP_922945.1  C-type lectin domain family 7 member A isoform f

      See identical proteins and their annotated locations for NP_922945.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, one of which results in an early stop codon. The resulting protein (isoform f) has a distinct C-terminus and is much shorter than isoform a.
      Source sequence(s)
      BC013385, DA193873
      Consensus CDS
      CCDS8617.1
      UniProtKB/TrEMBL
      A0A0S2Z5Q1
      Related
      ENSP00000312089.4, ENST00000310002.4
      Conserved Domains (1) summary
      pfam08391
      Location:4067
      Ly49; Ly49-like protein, N-terminal region

    RNA

    1. NR_125336.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK294111, AY359002, DA193873

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10116777..10130304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429359.1XP_047285315.1  C-type lectin domain family 7 member A isoform X1

      UniProtKB/Swiss-Prot
      B2R861, B7Z494, B7Z5A9, B7Z5B9, Q6IPS7, Q96D32, Q96DR9, Q96LD3, Q96PA4, Q96PA5, Q96PA6, Q96PA7, Q96PA8, Q9BXN2, Q9H1K3
      Related
      ENSP00000432876.1, ENST00000529761.5
    2. XM_006719135.4XP_006719198.1  C-type lectin domain family 7 member A isoform X3

      See identical proteins and their annotated locations for XP_006719198.1

      UniProtKB/TrEMBL
      B7Z1Y8
      Related
      ENSP00000434392.1, ENST00000531192.5
      Conserved Domains (2) summary
      pfam08391
      Location:4067
      Ly49; Ly49-like protein, N-terminal region
      cl02432
      Location:120164
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    3. XM_047429360.1XP_047285316.1  C-type lectin domain family 7 member A isoform X4

    4. XM_024449132.2XP_024304900.1  C-type lectin domain family 7 member A isoform X2

      UniProtKB/TrEMBL
      A0A2Z5YRU4, B7Z1Y8
      Conserved Domains (2) summary
      pfam08391
      Location:4067
      Ly49; Ly49-like protein, N-terminal region
      cl02432
      Location:120164
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    5. XM_024449133.2XP_024304901.1  C-type lectin domain family 7 member A isoform X5

      UniProtKB/TrEMBL
      A0A2Z5YRT6
      Conserved Domains (2) summary
      pfam08391
      Location:4067
      Ly49; Ly49-like protein, N-terminal region
      cl02432
      Location:74118
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10003452..10016972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372903.1XP_054228878.1  C-type lectin domain family 7 member A isoform X1

      UniProtKB/Swiss-Prot
      B2R861, B7Z494, B7Z5A9, B7Z5B9, Q6IPS7, Q96D32, Q96DR9, Q96LD3, Q96PA4, Q96PA5, Q96PA6, Q96PA7, Q96PA8, Q9BXN2, Q9H1K3
    2. XM_054372904.1XP_054228879.1  C-type lectin domain family 7 member A isoform X3

      UniProtKB/TrEMBL
      B7Z1Y8

    RNA

    1. XR_008488661.1 RNA Sequence

    2. XR_008488662.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_197951.1: Suppressed sequence

      Description
      NM_197951.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_197952.1: Suppressed sequence

      Description
      NM_197952.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    3. NM_197953.1: Suppressed sequence

      Description
      NM_197953.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.