SPRY4-IT1 SPRY4 intronic transcript 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPRY4-IT1provided by HGNC
Official Full Name: SPRY4 intronic transcript 1provided by HGNC
Primary source: HGNC:HGNC:42394
See related: MIM:617617; AllianceGenome:HGNC:42394
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SPRIGHTLY
Summary: This gene produces a non-coding RNA that is upregulated in several different tumors, including melanoma and breast and prostate cancer cells. This transcript may mediate cell growth, proliferation, and apoptosis. It regulates levels of lipin 2, and therefore may be involved in lipid biosynthesis. The primary transcript is cleaved to release a mature product that localizes to the cytoplasm (PMID:25344859). The full length structure of the primary and cleaved transcripts is unclear, and it is possible that the primary transcript is a splice variant of SPRY4 (sprouty RTK signaling antagonist 4). [provided by RefSeq, Feb 2016]
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Genomic context

Location:: 5q31.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (142317620..142318322, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (142848231..142848933, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (141697185..141697887, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and biological analysis of LncSPRY4-IT1-targeted functional proteins in photoaging skin.
Title: Identification and biological analysis of LncSPRY4-IT1-targeted functional proteins in photoaging skin.
NF-kappaB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay.
Title: NF-κB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay.
Deregulation of long noncoding RNAs ANCR, TINCR, HOTTIP and SPRY4-IT1 in plasma of systemic sclerosis patients: SPRY4-IT1 as a novel biomarker of scleroderma and its subtypes.
Title: Deregulation of long noncoding RNAs ANCR, TINCR, HOTTIP and SPRY4-IT1 in plasma of systemic sclerosis patients: SPRY4-IT1 as a novel biomarker of scleroderma and its subtypes.
LncRNA SPRY4-IT1 regulates breast cancer cell stemness through competitively binding miR-6882-3p with TCF7L2.
Title: LncRNA SPRY4-IT1 regulates breast cancer cell stemness through competitively binding miR-6882-3p with TCF7L2.
Prognostic Value of Long Noncoding RNA SPRY4-IT1 on Survival Outcomes in Human Carcinomas: A Systematic Review and Meta-Analysis with TCGA Database.
Title: Prognostic Value of Long Noncoding RNA SPRY4-IT1 on Survival Outcomes in Human Carcinomas: A Systematic Review and Meta-Analysis with TCGA Database.
Clinical significance of SPRY4-IT1 in efficacy and survival prediction in breast cancer patients undergoing neoadjuvant chemotherapy.
Title: Clinical significance of SPRY4-IT1 in efficacy and survival prediction in breast cancer patients undergoing neoadjuvant chemotherapy.
Long noncoding RNA SPRY4-IT1 promotes proliferation and metastasis of hepatocellular carcinoma via mediating TNF signaling pathway.
Title: Long noncoding RNA SPRY4-IT1 promotes proliferation and metastasis of hepatocellular carcinoma via mediating TNF signaling pathway.
Expression profiling revealed up-regulation of three lncRNAs in breast cancer samples.
Title: Expression profiling revealed up-regulation of three lncRNAs in breast cancer samples.
LncRNA SPRY4IT1 promotes progression of osteosarcoma by regulating ZEB1 and ZEB2 expression through sponging of miR101 activity.
Title: LncRNA SPRY4‑IT1 promotes progression of osteosarcoma by regulating ZEB1 and ZEB2 expression through sponging of miR‑101 activity.
Findings indicate that the SPYR4-IT1/miR-101-3p/zinc finger E-box binding homeobox 1 protein (ZEB1) axis contributes to cervical cancer (CC) migration and invasion, which may provide novel insights into the function of lncRNA-driven tumorigenesis of CC.
Title: Long non-coding RNA SPRY4-IT1 promotes epithelial-mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

SPRY4 intronic transcript 1 (non-protein coding)

Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.