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    SIPA1L1 signal induced proliferation associated 1 like 1 [ Homo sapiens (human) ]

    Gene ID: 26037, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SIPA1L1provided by HGNC
    Official Full Name
    signal induced proliferation associated 1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:20284
    See related
    Ensembl:ENSG00000197555 MIM:617504; AllianceGenome:HGNC:20284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E6TP1; SPAR1
    Summary
    Predicted to enable GTPase activator activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; ephrin receptor signaling pathway; and regulation of postsynapse organization. Located in actin cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 7.9), spleen (RPKM 7.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SIPA1L1 in Genome Data Viewer
    Location:
    14q24.2
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (71320476..71741209)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (65525922..65946692)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (71787193..72207926)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370706 Neighboring gene Sharpr-MPRA regulatory region 2320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8671 Neighboring gene uncharacterized LOC107984654 Neighboring gene Sharpr-MPRA regulatory region 5380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5896 Neighboring gene SIPA1L1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8673 Neighboring gene PDZ domain containing 11 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8674 Neighboring gene small nucleolar RNA, C/D box 56B Neighboring gene RNA, 7SL, cytoplasmic 683, pseudogene Neighboring gene uncharacterized LOC145474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8679 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72072179-72072936 Neighboring gene uncharacterized LOC124903342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72220712-72221626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72225004-72225562 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:72240666-72241865 Neighboring gene Sharpr-MPRA regulatory region 15223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72315448-72316027 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:72318891-72319392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8680 Neighboring gene NANOG hESC enhancer GRCh37_chr14:72362092-72362593 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5901 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:72410437-72410648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72448203-72448816 Neighboring gene regulator of G protein signaling 6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:72542545-72543085 Neighboring gene uncharacterized LOC124903343 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:72621633-72622832

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle. Lee C, et al. Virology, 2007 Feb 5. PMID 16999984
    2. Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era. Bentley SR, et al. Genes (Basel), 2021 Mar 17. PMID 33802862, Free PMC Article
    3. RapGAPs in brain: multipurpose players in neuronal Rap signalling. Spilker C, et al. Eur J Neurosci, 2010 Jul. PMID 20576033
    4. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. Gao Q, et al. Mol Cell Biol, 1999 Jan. PMID 9858596, Free PMC Article
    5. Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3. Dolnik A, et al. J Neurochem, 2016 Jan. PMID 26364583

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era.
      Title: Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era.
    2. Sipa1L1 is conserved across species, has a distinct expression pattern in brain and is localized to excitatory postsynapses.
      Title: Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.
    3. investigated the consequences of human papillomavirus 31 E6 binding to E6TP1; observed that binding & degradation of E6TP1 by HPV type 31 E6 are required to extend life span of keratinocytes & the long-term, stable replication of the viral genome
      Title: Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37213, KIAA0440, DKFZp686G1344

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in activation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    signal-induced proliferation-associated 1-like protein 1
    Names
    SIPA1-like protein 1
    high-risk human papilloma viruses E6 oncoproteins targeted protein 1
    spine-associated RapGAP 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284245.3 → NP_001271174.1  signal-induced proliferation-associated 1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001271174.1

      Status: VALIDATED

      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, DA330003
      Consensus CDS
      CCDS61490.1
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1716 → 1771
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1483 → 1728
      SPAR_C; C-terminal domain of SPAR protein

    2. NM_001284246.2 → NP_001271175.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001271175.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
      Source sequence(s)
      AC004900, AC004974, AF090989, AK122930
      Consensus CDS
      CCDS61491.1
      UniProtKB/TrEMBL
      A6H8W6
      Related
      ENSP00000351352.2, ENST00000358550.6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1715 → 1770
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1483 → 1727
      SPAR_C; C-terminal domain of SPAR protein

    3. NM_001284247.3 → NP_001271176.1  signal-induced proliferation-associated 1-like protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001271176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AB007900, AC004900, AC004968, AL707661, BM697295, CR936651, DA034212, DA184827, DA265109, DA330003, DT219010
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1736 → 1791
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1504 → 1748
      SPAR_C; C-terminal domain of SPAR protein

    4. NM_001354285.2 → NP_001341214.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AF090990, DA330003
      Consensus CDS
      CCDS9807.1
      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1737 → 1792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1504 → 1749
      SPAR_C; C-terminal domain of SPAR protein

    5. NM_001354286.2 → NP_001341215.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, AK122930, DA330003
      Consensus CDS
      CCDS61491.1
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1715 → 1770
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1483 → 1727
      SPAR_C; C-terminal domain of SPAR protein

    6. NM_001354287.2 → NP_001341216.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AF090989, AK122930, DA330003
      Consensus CDS
      CCDS61491.1
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1715 → 1770
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1483 → 1727
      SPAR_C; C-terminal domain of SPAR protein

    7. NM_001354288.2 → NP_001341217.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AF090989, AK122930, DA330003
      Consensus CDS
      CCDS61491.1
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1715 → 1770
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1483 → 1727
      SPAR_C; C-terminal domain of SPAR protein

    8. NM_001354289.2 → NP_001341218.1  signal-induced proliferation-associated 1-like protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, DA330003
      UniProtKB/TrEMBL
      F5GYF8
      Conserved Domains (4) summary
      cd00992
      Location:459 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:135 → 315
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1221 → 1276
      ZapB; Cell division protein ZapB
      pfam11881
      Location:989 → 1233
      SPAR_C; C-terminal domain of SPAR protein

    9. NM_001386936.1 → NP_001373865.1  signal-induced proliferation-associated 1-like protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476
      Consensus CDS
      CCDS61490.1
      UniProtKB/TrEMBL
      A6H8W6
      Related
      ENSP00000370630.3, ENST00000381232.8
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1716 → 1771
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1483 → 1728
      SPAR_C; C-terminal domain of SPAR protein

    10. NM_015556.4 → NP_056371.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AC005994, AF090990, DA330003
      Consensus CDS
      CCDS9807.1
      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1737 → 1792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1504 → 1749
      SPAR_C; C-terminal domain of SPAR protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      71320476..71741209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431217.1 → XP_047287173.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    2. XM_047431229.1 → XP_047287185.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    3. XM_047431218.1 → XP_047287174.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    4. XM_047431243.1 → XP_047287199.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    5. XM_047431251.1 → XP_047287207.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    6. XM_047431209.1 → XP_047287165.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    7. XM_047431239.1 → XP_047287195.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    8. XM_047431245.1 → XP_047287201.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    9. XM_047431253.1 → XP_047287209.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F5GYF8

    10. XM_047431219.1 → XP_047287175.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    11. XM_047431238.1 → XP_047287194.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    12. XM_047431247.1 → XP_047287203.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    13. XM_047431246.1 → XP_047287202.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    14. XM_024449529.2 → XP_024305297.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1737 → 1792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1504 → 1749
      SPAR_C; C-terminal domain of SPAR protein

    15. XM_017021198.2 → XP_016876687.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    16. XM_047431249.1 → XP_047287205.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    17. XM_047431252.1 → XP_047287208.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F5GYF8

    18. XM_047431223.1 → XP_047287179.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    19. XM_047431248.1 → XP_047287204.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    20. XM_047431241.1 → XP_047287197.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    21. XM_011536632.2 → XP_011534934.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011534934.1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1737 → 1792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1504 → 1749
      SPAR_C; C-terminal domain of SPAR protein

    22. XM_047431250.1 → XP_047287206.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    23. XM_047431220.1 → XP_047287176.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    24. XM_047431224.1 → XP_047287180.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    25. XM_047431242.1 → XP_047287198.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    26. XM_047431231.1 → XP_047287187.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    27. XM_047431227.1 → XP_047287183.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    28. XM_047431215.1 → XP_047287171.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    29. XM_047431240.1 → XP_047287196.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    30. XM_047431213.1 → XP_047287169.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    31. XM_047431214.1 → XP_047287170.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    32. XM_047431212.1 → XP_047287168.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    33. XM_047431226.1 → XP_047287182.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    34. XM_047431211.1 → XP_047287167.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    35. XM_047431222.1 → XP_047287178.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    36. XM_047431244.1 → XP_047287200.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    37. XM_047431232.1 → XP_047287188.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H8W6

    38. XM_047431233.1 → XP_047287189.1  signal-induced proliferation-associated 1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A6H8W6

    39. XM_047431234.1 → XP_047287190.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A6H8W6

    40. XM_047431235.1 → XP_047287191.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A6H8W6

    41. XM_047431236.1 → XP_047287192.1  signal-induced proliferation-associated 1-like protein 1 isoform X6

      UniProtKB/TrEMBL
      A6H8W6

    42. XM_047431237.1 → XP_047287193.1  signal-induced proliferation-associated 1-like protein 1 isoform X7

      UniProtKB/TrEMBL
      A6H8W6

    43. XM_047431228.1 → XP_047287184.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    44. XM_047431225.1 → XP_047287181.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    45. XM_047431216.1 → XP_047287172.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    46. XM_005267516.5 → XP_005267573.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005267573.1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Related
      ENSP00000450832.1, ENST00000555818.5
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1737 → 1792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1504 → 1749
      SPAR_C; C-terminal domain of SPAR protein

    47. XM_017021185.2 → XP_016876674.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:953 → 1023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629 → 809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1736 → 1791
      ZapB; Cell division protein ZapB
      pfam11881
      Location:1504 → 1748
      SPAR_C; C-terminal domain of SPAR protein

    48. XM_011536638.3 → XP_011534940.1  signal-induced proliferation-associated 1-like protein 1 isoform X11

      UniProtKB/TrEMBL
      F5GYF8
      Related
      ENSP00000440682.1, ENST00000537413.5
      Conserved Domains (4) summary
      cd00992
      Location:428 → 498
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:104 → 284
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:1212 → 1267
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:979 → 1224
      SPAR_C; C-terminal domain of SPAR protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      65525922..65946692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375796.1 → XP_054231771.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    2. XM_054375805.1 → XP_054231780.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    3. XM_054375797.1 → XP_054231772.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    4. XM_054375795.1 → XP_054231770.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    5. XM_054375802.1 → XP_054231777.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    6. XM_054375803.1 → XP_054231778.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    7. XM_054375794.1 → XP_054231769.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    8. XM_054375801.1 → XP_054231776.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    9. XM_054375825.1 → XP_054231800.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    10. XM_054375791.1 → XP_054231766.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    11. XM_054375811.1 → XP_054231786.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H8W6

    12. XM_054375813.1 → XP_054231788.1  signal-induced proliferation-associated 1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A6H8W6

    13. XM_054375814.1 → XP_054231789.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A6H8W6

    14. XM_054375815.1 → XP_054231790.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A6H8W6

    15. XM_054375816.1 → XP_054231791.1  signal-induced proliferation-associated 1-like protein 1 isoform X6

      UniProtKB/TrEMBL
      A6H8W6

    16. XM_054375817.1 → XP_054231792.1  signal-induced proliferation-associated 1-like protein 1 isoform X7

      UniProtKB/TrEMBL
      A6H8W6

    17. XM_054375808.1 → XP_054231783.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    18. XM_054375804.1 → XP_054231779.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    19. XM_054375809.1 → XP_054231784.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    20. XM_054375823.1 → XP_054231798.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    21. XM_054375833.1 → XP_054231808.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    22. XM_054375793.1 → XP_054231768.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    23. XM_054375820.1 → XP_054231795.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    24. XM_054375826.1 → XP_054231801.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    25. XM_054375835.1 → XP_054231810.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F5GYF8

    26. XM_054375798.1 → XP_054231773.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    27. XM_054375819.1 → XP_054231794.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    28. XM_054375828.1 → XP_054231803.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    29. XM_054375827.1 → XP_054231802.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    30. XM_054375807.1 → XP_054231782.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    31. XM_054375818.1 → XP_054231793.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    32. XM_054375830.1 → XP_054231805.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    33. XM_054375834.1 → XP_054231809.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F5GYF8

    34. XM_054375821.1 → XP_054231796.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    35. XM_054375799.1 → XP_054231774.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    36. XM_054375800.1 → XP_054231775.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    37. XM_054375810.1 → XP_054231785.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    38. XM_054375829.1 → XP_054231804.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    39. XM_054375832.1 → XP_054231807.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    40. XM_054375822.1 → XP_054231797.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    41. XM_054375824.1 → XP_054231799.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8

    42. XM_054375831.1 → XP_054231806.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8

    43. XM_054375806.1 → XP_054231781.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    44. XM_054375792.1 → XP_054231767.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6

    45. XM_054375812.1 → XP_054231787.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H8W6

    46. XM_054375836.1 → XP_054231811.1  signal-induced proliferation-associated 1-like protein 1 isoform X11

      UniProtKB/TrEMBL
      F5GYF8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43166.4 GenPept UniProtKB/Swiss-Prot:O43166

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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