HDAC6 histone deacetylase 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HDAC6provided by HGNC
Official Full Name: histone deacetylase 6provided by HGNC
Primary source: HGNC:HGNC:14064
See related: Ensembl:ENSG00000094631 MIM:300272; AllianceGenome:HGNC:14064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HD6; JM21; CPBHM; KDAC6; PPP1R90
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in kidney (RPKM 18.6), testis (RPKM 15.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp11.23

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (48801398..48824982)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (48211870..48235478)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (48659805..48683392)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity.
Title: HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity.
Regulation of STAT1 Signaling in Human Pancreatic beta-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?
Title: Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?
Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.
Title: Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.
HDAC6-mediated deacetylation of FLOT2 maintains stability and tumorigenic function of FLOT2 in nasopharyngeal carcinoma.
Title: HDAC6-mediated deacetylation of FLOT2 maintains stability and tumorigenic function of FLOT2 in nasopharyngeal carcinoma.
HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.
Title: HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.
Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.
Title: Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.
HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent.
Title: HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent.
HTRA1 promotes EMT through the HDAC6/Ac-alpha-tubulin pathway in human GBM cells.
Title: HTRA1 promotes EMT through the HDAC6/Ac-α-tubulin pathway in human GBM cells.
Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
Title: Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
Histone deacetylase 6: at the interface of cancer and neurodegeneration.
Title: Histone deacetylase 6: at the interface of cancer and neurodegeneration.

Submit: New GeneRIF Correction See all GeneRIFs (303)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
X-linked dominant chondrodysplasia, Chassaing-Lacombe type MedGen: C3275476 OMIM: 300863 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infectivity is decreased by HDAC6 overexpression in the virus producing cells (HEK293T)	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion	PubMed
Envelope transmembrane glycoprotein gp41	env	Overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and remarkably prevents HIV-1 gp120/41-dependent cell fusion	PubMed
Tat	tat	HIV-1 Tat-induced phosphorylation of CHUK (IKKalpha), IKBKB (IKKbeta), and RELA (p65) and NFKBI (IkappaBalpha) degradation are enhanced by HDAC6 in CRT-MG human astroglioma cells suggesting that HDAC6 is responsible for HIV-1 Tat-induced NF-kB activation	PubMed
	tat	HIV-1 Tat-induced JUN (AP1) DNA binding activity is enhanced by HDAC6 in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat-induced phosphorylation of JUN (AP1) is enhanced by HDAC6 in CRT-MG human astroglioma cells suggesting that HDAC6 participates in HIV-1 Tat-induced regulation of JUN (AP1) signaling cascades	PubMed
	tat	HIV-1 Tat-induced phosphorylation of MAPK1, MAPK3, MAPK14 and MAPK8 proteins is enhanced by HDAC6 in CRT-MG human astroglioma cells suggesting that HDAC6 is responsible for HIV-1 Tat-induced activation of MAPKs	PubMed
	tat	HIV-1 Tat-induced increase in expression of ICAM1 is enhanced by HDAC6 in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat-induced increase in expression of CCL2, CXCL8 and CXCL10 is enhanced by HDAC6 in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat increases HDAC6 mRNA and protein expression levels in time- and dose-dependent manner and correlates with a reduced level of acetylated alpha-tubulin in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat and HDAC6 interact in the cytoplasm in a microtubule-dependent manner, which leads to deacetylate Tat at position Lys28 and to inhibit Tat-mediated transactivation	PubMed
Vif	vif	HIV-1 Vif interacts with endogeneous non-degraded APOBEC3G (and HDAC6) when overexpressed in CEM.NKR.CCR5 cells as demonstrated by co-IP using cell lysates treated with Rnase A (suggesting interaction is direct protein-protein and not tethered by RNA)	PubMed
	vif	HIV-1 degradation is mediated by HDAC6 overexpression in HEK293T cells and is independent of the APOBEC3G-Vif interaction	PubMed
	vif	HIV-1 Vif-mediated APOBEC3G ubiquitination and proteasome degradation is inhibited by HDAC6	PubMed
	vif	HIV-1 Vif complexes with HDAC6 and APOBEC3G to form a ternary complex as demonstrated by co-IP assay using HEK293T cells lysates	PubMed
	vif	HIV-1 Vif binds HDAC6 as demonstrated by GST-Vif, HA-HDAC6 pull-down assay	PubMed
	vif	HIV-1 Vif protein expression is decreased by overexpression of HDAC6 in HEK293T cells without affecting endogeneous CBFB protein levels and this decrease is dependent on the C-terminal Buz domain of HDAC6 protein	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXS6992E (e-PCR)
- UniSTS:17934

1916 (e-PCR)
- UniSTS:6419

D8S2279 (e-PCR)
- UniSTS:473907

A002Y02 (e-PCR)
- UniSTS:50844

WI-8811 (e-PCR)
- UniSTS:7673

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables acetylspermidine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables dynein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone H3K14 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K12 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K5 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K8 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables misfolded protein binding	EXP Inferred from Experiment more info	PubMed
enables polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables tau protein binding	IDA Inferred from Direct Assay more info	PubMed
enables tau protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed
enables tau protein binding	TAS Traceable Author Statement more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin deacetylase activity	EXP Inferred from Experiment more info	PubMed
enables tubulin deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables tubulin deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tubulin deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin deacetylase activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in aggresome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal transport of mitochondrion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to heat	TAS Traceable Author Statement more info
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to misfolded protein	IEA Inferred from Electronic Annotation more info
involved_in cellular response to parathyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to topologically incorrect protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	TAS Traceable Author Statement more info
involved_in cilium disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cilium disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in erythrocyte enucleation	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of aggrephagy	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hydrogen peroxide metabolic process	IC Inferred by Curator more info	PubMed
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidoreductase activity	IC Inferred by Curator more info	PubMed
involved_in negative regulation of protein acetylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein-containing complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in polyamine deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in polyubiquitinated misfolded protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholangiocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tubulin deacetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type 2 mitophagy	IEA Inferred from Electronic Annotation more info
involved_in protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deacetylation	TAS Traceable Author Statement more info	PubMed
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex disassembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of androgen receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of autophagy	TAS Traceable Author Statement more info	PubMed
involved_in regulation of autophagy of mitochondrion	TAS Traceable Author Statement more info	PubMed
involved_in regulation of establishment of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule-based movement	IC Inferred by Curator more info	PubMed
involved_in regulation of mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
involved_in response to corticosterone	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to growth factor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to immobilization stress	IEA Inferred from Electronic Annotation more info
involved_in response to misfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in spermidine deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tubulin deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tubulin deacetylation	TAS Traceable Author Statement more info	PubMed
involved_in type 2 mitophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in aggresome	IDA Inferred from Direct Assay more info	PubMed
located_in aggresome	TAS Traceable Author Statement more info	PubMed
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed
located_in inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone deacetylase 6

Names: alpha-tubulin deacetylase HDAC6; protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; tubulin-lysine deacetylase HDAC6

NP_001308154.1

EC 3.5.1.98

NP_001308155.1

EC 3.5.1.98

NP_001308156.1

EC 3.5.1.98

NP_001308157.1

EC 3.5.1.98

NP_001308158.1

EC 3.5.1.98

NP_001308159.1

EC 3.5.1.98

NP_001308160.1

EC 3.5.1.98

NP_006035.2

EC 3.5.1.98

XP_047297659.1

EC 3.5.1.98

XP_047297660.1

EC 3.5.1.98

XP_047297661.1

EC 3.5.1.98

XP_047297662.1

EC 3.5.1.98

XP_047297663.1

EC 3.5.1.98

XP_054182248.1

EC 3.5.1.98

XP_054182249.1

EC 3.5.1.98

XP_054182250.1

EC 3.5.1.98

XP_054182251.1

EC 3.5.1.98

XP_054182252.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012560.2 RefSeqGene

Range

5671..28580

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001321225.2 → NP_001308154.1 histone deacetylase 6 isoform a

Status: REVIEWED

Source sequence(s)

AK302926, AL137696, DC402494

UniProtKB/TrEMBL

A0A8V8TKY7, B4DZH6

Related

ENST00000697246.1

Conserved Domains (3) summary

cd10003
Location:499 → 849

HDAC6-dom2; Histone deacetylase 6, domain 2

cd11682
Location:113 → 449

HDAC6-dom1; Histone deacetylase 6, domain 1

pfam02148
Location:1147 → 1209

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
NM_001321226.2 → NP_001308155.1 histone deacetylase 6 isoform b

Status: REVIEWED

Source sequence(s)

AC231533

Consensus CDS

CCDS14306.1

UniProtKB/Swiss-Prot

O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7

UniProtKB/TrEMBL

A0A8V8TKY7

Related

ENSP00000402751.2, ENST00000443563.6

Conserved Domains (4) summary

cd10003
Location:485 → 835

HDAC6-dom2; Histone deacetylase 6, domain 2

cd11682
Location:99 → 435

HDAC6-dom1; Histone deacetylase 6, domain 1

pfam05109
Location:838 → 1071

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02148
Location:1133 → 1195

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
NM_001321227.2 → NP_001308156.1 histone deacetylase 6 isoform b

Status: REVIEWED

Source sequence(s)

AC231533

Consensus CDS

CCDS14306.1

UniProtKB/Swiss-Prot

O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7

UniProtKB/TrEMBL

A0A8V8TKY7

Related

ENSP00000496013.1, ENST00000644068.1

Conserved Domains (4) summary

cd10003
Location:485 → 835

HDAC6-dom2; Histone deacetylase 6, domain 2

cd11682
Location:99 → 435

HDAC6-dom1; Histone deacetylase 6, domain 1

pfam05109
Location:838 → 1071

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02148
Location:1133 → 1195

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
NM_001321228.2 → NP_001308157.1 histone deacetylase 6 isoform b

Status: REVIEWED

Source sequence(s)

AC231533

Consensus CDS

CCDS14306.1

UniProtKB/Swiss-Prot

O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7

UniProtKB/TrEMBL

A0A8V8TKY7

Related

ENSP00000496046.1, ENST00000643374.2

Conserved Domains (4) summary

cd10003
Location:485 → 835

HDAC6-dom2; Histone deacetylase 6, domain 2

cd11682
Location:99 → 435

HDAC6-dom1; Histone deacetylase 6, domain 1

pfam05109
Location:838 → 1071

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02148
Location:1133 → 1195

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
NM_001321229.1 → NP_001308158.1 histone deacetylase 6 isoform b

Status: REVIEWED

Source sequence(s)

AC231533

Consensus CDS

CCDS14306.1

UniProtKB/Swiss-Prot

O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7

UniProtKB/TrEMBL

A0A8V8TKY7

Related

ENSP00000365795.3, ENST00000376610.7

Conserved Domains (4) summary

cd10003
Location:485 → 835

HDAC6-dom2; Histone deacetylase 6, domain 2

cd11682
Location:99 → 435

HDAC6-dom1; Histone deacetylase 6, domain 1

pfam05109
Location:838 → 1071

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02148
Location:1133 → 1195

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
NM_001321230.2 → NP_001308159.1 histone deacetylase 6 isoform c

Status: REVIEWED

Source sequence(s)

AC231533, BC005872, BC011498

Consensus CDS

CCDS87740.1

UniProtKB/TrEMBL

A0A2R8YD35, C9J172, C9JEF4, E9PEH1, Q9BRX7

Related

ENSP00000496727.1, ENST00000462730.5

Conserved Domains (1) summary

cl17011
Location:99 → 145

Arginase_HDAC; Arginase-like and histone-like hydrolases
NM_001321231.2 → NP_001308160.1 histone deacetylase 6 isoform c

Status: REVIEWED

Source sequence(s)

AC231533, BC005872

Consensus CDS

CCDS87740.1

UniProtKB/TrEMBL

A0A2R8YD35, C9J172, C9JEF4, E9PEH1, Q9BRX7

Related

ENSP00000494447.1, ENST00000465269.6

Conserved Domains (1) summary

cl17011
Location:99 → 145

Arginase_HDAC; Arginase-like and histone-like hydrolases
NM_006044.4 → NP_006035.2 histone deacetylase 6 isoform b

See identical proteins and their annotated locations for NP_006035.2

Status: REVIEWED

Source sequence(s)

AC231533, AJ011972, AL137696, DC377684

Consensus CDS

CCDS14306.1

UniProtKB/Swiss-Prot

O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7

UniProtKB/TrEMBL

A0A8V8TKY7

Related

ENSP00000334061.5, ENST00000334136.11

Conserved Domains (4) summary

cd10003
Location:485 → 835

HDAC6-dom2; Histone deacetylase 6, domain 2

cd11682
Location:99 → 435

HDAC6-dom1; Histone deacetylase 6, domain 1

pfam05109
Location:838 → 1071

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02148
Location:1133 → 1195

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RNA

NR_135591.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC231533

Related

ENST00000697890.1
NR_135592.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AC231533, AK295884, BC005872
NR_135593.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AC231533, BC005872, DA191923

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

48801398..48824982

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441703.1 → XP_047297659.1 histone deacetylase 6 isoform X1

UniProtKB/TrEMBL

A0A8V8TKY7
XM_047441704.1 → XP_047297660.1 histone deacetylase 6 isoform X2

UniProtKB/TrEMBL

A0A8V8TKY7, B4DZH6
XM_047441707.1 → XP_047297663.1 histone deacetylase 6 isoform X4

UniProtKB/TrEMBL

A0A2R8Y6Z9

Related

ENSP00000495932.2, ENST00000480525.6
XM_047441705.1 → XP_047297661.1 histone deacetylase 6 isoform X3

UniProtKB/TrEMBL

A0A8V8TLA9

Related

ENSP00000513468.1, ENST00000697886.1
XM_047441706.1 → XP_047297662.1 histone deacetylase 6 isoform X3

UniProtKB/TrEMBL

A0A8V8TLA9

RNA

XR_007068179.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

48211870..48235478

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054326274.1 → XP_054182249.1 histone deacetylase 6 isoform X2

UniProtKB/TrEMBL

A0A8V8TKY7, B4DZH6
XM_054326273.1 → XP_054182248.1 histone deacetylase 6 isoform X1

UniProtKB/TrEMBL

A0A8V8TKY7
XM_054326277.1 → XP_054182252.1 histone deacetylase 6 isoform X4

UniProtKB/TrEMBL

A0A2R8Y6Z9
XM_054326275.1 → XP_054182250.1 histone deacetylase 6 isoform X3

UniProtKB/TrEMBL

A0A8V8TLA9
XM_054326276.1 → XP_054182251.1 histone deacetylase 6 isoform X3

UniProtKB/TrEMBL

A0A8V8TLA9