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    LINC00324 long intergenic non-protein coding RNA 324 [ Homo sapiens (human) ]

    Gene ID: 284029, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00324provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 324provided by HGNC
    Primary source
    HGNC:HGNC:26628
    See related
    Ensembl:ENSG00000178977 AllianceGenome:HGNC:26628
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17orf44; RNA00324; TP53LC03; NCRNA00324
    Expression
    Ubiquitous expression in lymph node (RPKM 2.5), spleen (RPKM 2.2) and 24 other tissues See more
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    Genomic context

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    See LINC00324 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8220630..8224043, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8126855..8130271, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8123948..8127361, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11683 Neighboring gene nonconserved acetylation island sequence 72 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8107017-8107517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8113125-8113784 Neighboring gene aurora kinase B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:8124016-8124902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8176 Neighboring gene tRNA-Trp (anticodon CCA) 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8126237-8126978 Neighboring gene tRNA-Gly (anticodon TCC) 3-1 Neighboring gene tRNA-Asp (anticodon GTC) 2-11 Neighboring gene tRNA-Pro (anticodon CGG) 1-3 Neighboring gene tRNA-Thr (anticodon AGT) 1-2 Neighboring gene tRNA-Ser (anticodon AGA) 2-6 Neighboring gene CST telomere replication complex component 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p. Ni S, et al. J Obstet Gynaecol, 2023 Dec. PMID 38059417
    2. Long intergenic non-coding RNA 00324 promotes gastric cancer cell proliferation via binding with HuR and stabilizing FAM83B expression. Zou Z, et al. Cell Death Dis, 2018 Jun 18. PMID 29915327, Free PMC Article
    3. LINC00324 accelerates the proliferation and migration of osteosarcoma through regulating WDR66. Wu S, et al. J Cell Physiol, 2020 Jan. PMID 31225659
    4. [Correlation analysis between LINC00324 and immunophenotype in peripheral blood leukocytes in patients with acute myeloid leukemia]. Liu Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2019 Sep. PMID 31750827
    5. Long intergenic non-protein coding RNA 324 prevents breast cancer progression by modulating miR-10b-5p. Wang B, et al. Aging (Albany NY), 2020 Apr 18. PMID 32305959, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysregulation of LINC00324 promotes poor prognosis in patients with glioma.
      Title: Dysregulation of LINC00324 promotes poor prognosis in patients with glioma.
    2. Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p.
      Title: Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p.
    3. A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
      Title: A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
    4. LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway.
      Title: LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway.
    5. LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
      Title: LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
    6. A concise review on the role of LINC00324 in different cancers.
      Title: A concise review on the role of LINC00324 in different cancers.
    7. LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
      Title: LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
    8. LINC00324 facilitates cell proliferation through competing for miR2145p in immature ovarian teratocarcinoma.
      Title: LINC00324 facilitates cell proliferation through competing for miR‑214‑5p in immature ovarian teratocarcinoma.
    9. Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p.
      Title: Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p.
    10. Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway.
      Title: Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • FLJ34790, MGC104931

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026951.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC135178, AK092109, BC089396
      Related
      ENST00000315707.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      8220630..8224043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      8126855..8130271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173621.1: Suppressed sequence

      Description
      NM_173621.1: This RefSeq was permanently suppressed because currently there is support for the transcript, but not for the protein, and it is a candidate for nonsense-mediated decay.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials