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    COX16 Cox16p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX16
    Official Full Name
    Cox16p
    Primary source
    SGD:S000003540
    Locus tag
    YJL003W
    See related
    AllianceGenome:SGD:S000003540; FungiDB:YJL003W; VEuPathDB:YJL003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COX16 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (432644..433000)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene adenylate cyclase Neighboring gene Sys1p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 Neighboring gene proteasome core particle subunit beta 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COX16 encodes a novel protein required for the assembly of cytochrome oxidase in Saccharomyces cerevisiae. Carlson CG, et al. J Biol Chem, 2003 Feb 7. PMID 12446688
    2. COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2. Cerqua C, et al. Biochim Biophys Acta Bioenerg, 2018 Apr. PMID 29355485
    3. Cox16 protein is physically associated with Cox1p assembly intermediates and with cytochrome oxidase. Su CH, et al. J Biol Chem, 2017 Sep 29. PMID 28821616, Free PMC Article
    4. Sensitivity to Sn2+ of the yeast Saccharomyces cerevisiae depends on general energy metabolism, metal transport, anti-oxidative defences, and DNA repair. Viau C, et al. Biometals, 2006 Dec. PMID 16691319
    5. Phenomic and transcriptomic analyses reveal that autophagy plays a major role in desiccation tolerance in Saccharomyces cerevisiae. Ratnakumar S, et al. Mol Biosyst, 2011 Jan. PMID 20963216

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cox16p
    NP_012531.1
    • Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      432644..433000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181437.1 → NP_012531.1  TPA: Cox16p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012531.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWH2, P47081
      UniProtKB/TrEMBL
      A6ZPW4, B3LQ96, C7GUU2, D3UF66, G2WH07, N1P1F4
      Conserved Domains (1) summary
      pfam14138
      Location:35 → 111
      COX16; Cytochrome c oxidase assembly protein COX16
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47081.1

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