U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RNLS renalase, FAD dependent amine oxidase [ Homo sapiens (human) ]

    Gene ID: 55328, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RNLSprovided by HGNC
    Official Full Name
    renalase, FAD dependent amine oxidaseprovided by HGNC
    Primary source
    HGNC:HGNC:25641
    See related
    Ensembl:ENSG00000184719 MIM:609360; AllianceGenome:HGNC:25641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf59; RENALASE
    Summary
    Enables several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in negative regulation of blood pressure and negative regulation of heart rate. Located in extracellular region. Implicated in essential hypertension and hypertension. Biomarker of end stage renal disease. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RNLS in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88171523..88583318, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89050656..89467392, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90033619..90343075, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378415 Neighboring gene Sharpr-MPRA regulatory region 10781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3719 Neighboring gene uncharacterized LOC105378416 Neighboring gene uncharacterized LOC101929727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3722 Neighboring gene vomeronasal 1 receptor 55 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:90107282-90107945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3724 Neighboring gene lipase family member J Neighboring gene ribosomal protein L7 pseudogene 34 Neighboring gene lipase F, gastric type

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The catalytic function of renalase: A decade of phantoms. Moran GR. Biochim Biophys Acta, 2016 Jan. PMID 25900362
    2. Kinetics and equilibria of the reductive and oxidative half-reactions of human renalase with α-NADPH. Beaupre BA, et al. Biochemistry, 2013 Dec 10. PMID 24266457
    3. Serum renalase is related to catecholamine levels and renal function. Wang F, et al. Clin Exp Nephrol, 2015 Feb. PMID 24590362
    4. Renalase gene polymorphism in patients with hypertension and concomitant coronary heart disease. Li X, et al. Kidney Blood Press Res, 2014. PMID 24821235
    5. Renalase gene polymorphism in patients after renal allograft transplantation. Pawlik A, et al. Kidney Blood Press Res, 2014. PMID 24923329

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea.
      Title: Renalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea.
    2. Coexistence of Cardiovascular Risk Factors and Blood Renalase Concentration.
      Title: Coexistence of Cardiovascular Risk Factors and Blood Renalase Concentration.
    3. [The association of renalase single-nucleotide polymorphisms rs2576178 and rs10887800 with hypertension in patients with obstructive sleep apnea].
      Title: [The association of renalase single-nucleotide polymorphisms rs2576178 and rs10887800 with hypertension in patients with obstructive sleep apnea].
    4. The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease.
      Title: The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease.
    5. Role of serum renalase levels in predicting the presence of metabolic syndrome in patients with polycystic ovary syndrome.
      Title: Role of serum renalase levels in predicting the presence of metabolic syndrome in patients with polycystic ovary syndrome.
    6. Plasma renalase levels are associated with the development of acute pancreatitis.
      Title: Plasma renalase levels are associated with the development of acute pancreatitis.
    7. Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation.
      Title: Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation.
    8. Evaluation of the association of the Renalase rs10887800 polymorphism with the risk of preeclampsia in Brazilian women.
      Title: Evaluation of the association of the Renalase rs10887800 polymorphism with the risk of preeclampsia in Brazilian women.
    9. The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.
      Title: The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.
    10. Renalase gene polymorphisms and plasma levels are associated with preeclampsia: a hospital-based study in the Chinese cohort.
      Title: Renalase gene polymorphisms and plasma levels are associated with preeclampsia: a hospital-based study in the Chinese cohort.
    Submit: New GeneRIF Correction See all GeneRIFs (77)

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ11218

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NADH binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables epinephrine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoamine oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of heart rate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to catecholamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to epinephrine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to salt IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    renalase
    Names
    MAO-C
    alpha-NAD(P)H oxidase/anomerase
    monoamine oxidase-C
    NP_001026879.2
    NP_060833.1
    XP_005270004.1
    XP_005270005.1
    XP_005270006.1
    XP_011538226.1
    XP_011538229.1
    XP_016871869.1
    XP_016871870.1
    XP_016871871.1
    XP_016871873.1
    XP_016871874.1
    XP_047281391.1
    XP_047281392.1
    XP_054222197.1
    XP_054222198.1
    XP_054222199.1
    XP_054222200.1
    XP_054222201.1
    XP_054222202.1
    XP_054222203.1
    XP_054222204.1
    XP_054222205.1
    XP_054222206.1
    XP_054222207.1
    XP_054222208.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031709.3 → NP_001026879.2  renalase isoform 1 precursor

      See identical proteins and their annotated locations for NP_001026879.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA854849, AL353149, BC005364, BM978857, BP332262
      Consensus CDS
      CCDS31239.1
      UniProtKB/Swiss-Prot
      Q5VYX0, Q9BS33, Q9NUP8
      Related
      ENSP00000332530.4, ENST00000331772.9
      Conserved Domains (3) summary
      COG3380
      Location:1 → 342
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
      pfam13450
      Location:6 → 80
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_018363.4 → NP_060833.1  renalase isoform 2 precursor

      See identical proteins and their annotated locations for NP_060833.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK002080, AL353149, BP332262
      Consensus CDS
      CCDS7388.1
      UniProtKB/Swiss-Prot
      Q5VYX0
      Related
      ENSP00000361015.3, ENST00000371947.7
      Conserved Domains (2) summary
      pfam13450
      Location:6 → 80
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      88171523..88583318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016382.3 → XP_016871871.1  renalase isoform X8

      UniProtKB/TrEMBL
      B4DJW3
      Conserved Domains (1) summary
      pfam13450
      Location:6 → 40
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    2. XM_011539924.4 → XP_011538226.1  renalase isoform X1

      See identical proteins and their annotated locations for XP_011538226.1

      UniProtKB/Swiss-Prot
      Q5VYX0
      Conserved Domains (2) summary
      pfam13450
      Location:6 → 80
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_017016380.3 → XP_016871869.1  renalase isoform X1

      UniProtKB/Swiss-Prot
      Q5VYX0
      Conserved Domains (2) summary
      pfam13450
      Location:6 → 80
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_017016384.3 → XP_016871873.1  renalase isoform X10

    5. XM_005269948.4 → XP_005270005.1  renalase isoform X6

      Conserved Domains (2) summary
      COG3380
      Location:41 → 259
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
      pfam13450
      Location:6 → 40
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    6. XM_005269947.3 → XP_005270004.1  renalase isoform X5

      Conserved Domains (2) summary
      pfam13450
      Location:6 → 80
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    7. XM_017016385.2 → XP_016871874.1  renalase isoform X11

    8. XM_047425436.1 → XP_047281392.1  renalase isoform X9

    9. XM_011539927.4 → XP_011538229.1  renalase isoform X3

      Conserved Domains (2) summary
      pfam13450
      Location:6 → 80
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    10. XM_047425435.1 → XP_047281391.1  renalase isoform X2

    11. XM_017016381.3 → XP_016871870.1  renalase isoform X4

    12. XM_005269949.6 → XP_005270006.1  renalase isoform X7

      Conserved Domains (2) summary
      pfam13450
      Location:6 → 80
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:109 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_001747122.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      89050656..89467392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366230.1 → XP_054222205.1  renalase isoform X8

    2. XM_054366222.1 → XP_054222197.1  renalase isoform X1

    3. XM_054366223.1 → XP_054222198.1  renalase isoform X1

    4. XM_054366229.1 → XP_054222204.1  renalase isoform X8

    5. XM_054366232.1 → XP_054222207.1  renalase isoform X10

    6. XM_054366227.1 → XP_054222202.1  renalase isoform X6

    7. XM_054366226.1 → XP_054222201.1  renalase isoform X5

    8. XM_054366233.1 → XP_054222208.1  renalase isoform X11

    9. XM_054366231.1 → XP_054222206.1  renalase isoform X9

    10. XM_054366224.1 → XP_054222199.1  renalase isoform X3

    11. XM_054366225.1 → XP_054222200.1  renalase isoform X4

    12. XM_054366228.1 → XP_054222203.1  renalase isoform X7

    RNA

    1. XR_008488226.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VYX0.1 GenPept UniProtKB/Swiss-Prot:Q5VYX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous