Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinf1provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade F, member 1provided by MGI
Primary source: MGI:MGI:108080
See related: Ensembl:ENSMUSG00000000753 AllianceGenome:MGI:108080
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pedf; Sdf3; EPC-1; Pedfl
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of angiogenesis. Acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study osteogenesis imperfecta type 6. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 193.9), mammary gland adult (RPKM 118.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.87 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75300855..75313449, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75410029..75422623, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model.
Title: PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model.
Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus.
Title: Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus.
ADAMTS5 promotes neovascularization via autophagic degradation of PEDF in proliferative diabetic retinopathy.
Title: ADAMTS5 promotes neovascularization via autophagic degradation of PEDF in proliferative diabetic retinopathy.
Deletion of the Pedf gene leads to inflammation, photoreceptor loss and vascular disturbances in the retina.
Title: Deletion of the Pedf gene leads to inflammation, photoreceptor loss and vascular disturbances in the retina.
Pigment epithelium-derived factor modulates periodontal homeostasis in mice and induces osteogenic differentiation of human periodontal ligament fibroblasts.
Title: Pigment epithelium-derived factor modulates periodontal homeostasis in mice and induces osteogenic differentiation of human periodontal ligament fibroblasts.
PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE.
Title: PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE.
Antagonism Between PEDF and TGF-beta Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis.
Title: Antagonism Between PEDF and TGF-β Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis.
Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex.
Title: Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex.
The Role of RAD6B and PEDF in Retinal Degeneration.
Title: The Role of RAD6B and PEDF in Retinal Degeneration.
Pigment epithelium-derived factor (PEDF) and PEDF-receptor in the adult mouse brain: Differential spatial/temporal localization pattern.
Title: Pigment epithelium-derived factor (PEDF) and PEDF-receptor in the adult mouse brain: Differential spatial/temporal localization pattern.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI195227 (e-PCR)
- UniSTS:180249

Serpinf1 (e-PCR), detects polymorphism
- UniSTS:507216

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to cobalt ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in ovulation cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to peptide	IEA Inferred from Electronic Annotation more info
involved_in response to peptide	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in short-term memory	IEA Inferred from Electronic Annotation more info
involved_in short-term memory	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon hillock	IEA Inferred from Electronic Annotation more info
located_in axon hillock	ISO Inferred from Sequence Orthology more info
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pigment epithelium-derived factor

Names: SDF-3; alpha-2 antiplasmin; caspin; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serine (or cysteine) proteinase inhibitor, clade F), member 1; serine (or cysteine) proteinase inhibitor, clade F, member 1; serpin F1; stromal cell-derived factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011340.3 → NP_035470.3 pigment epithelium-derived factor precursor

See identical proteins and their annotated locations for NP_035470.3

Status: VALIDATED

Source sequence(s)

AA111321, AF017057, AL591496, D50460

Consensus CDS

CCDS25045.1

UniProtKB/Swiss-Prot

O70629, O88691, P97298

Related

ENSMUSP00000000769.8, ENSMUST00000000769.14

Conserved Domains (1) summary

cd02052
Location:39 → 414

PEDF; Pigment epithelium-derived factor (PEDF)_like. PEDF is non-inhibitory member of the Serpin superfamily. It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems. This ...