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    Mnat1 menage a trois 1 [ Mus musculus (house mouse) ]

    Gene ID: 17420, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mnat1provided by MGI
    Official Full Name
    menage a trois 1provided by MGI
    Primary source
    MGI:MGI:106207
    See related
    Ensembl:ENSMUSG00000021103 AllianceGenome:MGI:106207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P36; MAT1; E130115E11Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and metal ion binding activity. Acts upstream of or within several processes, including adult heart development; response to calcium ion; and ventricular system development. Predicted to be located in nucleoplasm. Predicted to be part of CAK-ERCC2 complex; RNA polymerase II transcription regulator complex; and cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.1), limb E14.5 (RPKM 4.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Mnat1 in Genome Data Viewer
    Location:
    12 C3; 12 30.37 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (73158957..73320762)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73112185..73273988)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene sine oculis-related homeobox 6 Neighboring gene STARR-seq mESC enhancer starr_32458 Neighboring gene microRNA 9718 Neighboring gene STARR-seq mESC enhancer starr_32461 Neighboring gene sine oculis-related homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_32463 Neighboring gene sine oculis-related homeobox 4 Neighboring gene predicted gene, 23910 Neighboring gene STARR-positive B cell enhancer ABC_E4028 Neighboring gene STARR-positive B cell enhancer ABC_E7146 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9148 Neighboring gene STARR-seq mESC enhancer starr_32467 Neighboring gene TRM5 tRNA methyltransferase 5 Neighboring gene solute carrier family 38, member 6 Neighboring gene STARR-seq mESC enhancer starr_32469 Neighboring gene RIKEN cDNA D830013O20 gene Neighboring gene predicted gene, 40442

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA repair  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    acts_upstream_of_or_within adult heart development PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in nucleotide-excision repair  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within response to calcium ion PubMed 
    involved_in transcription initiation at RNA polymerase II promoter  
    involved_in transcription initiation at RNA polymerase II promoter  
    acts_upstream_of_or_within ventricular system development PubMed 
    Component Evidence Code Pubs
    part_of CAK-ERCC2 complex  
    part_of CAK-ERCC2 complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    located_in nucleoplasm  
    part_of transcription factor TFIIH core complex  
    part_of transcription factor TFIIH core complex  
    part_of transcription factor TFIIH holo complex  
    part_of transcription factor TFIIH holo complex  
    part_of transcription factor TFIIH holo complex  
    part_of transcription factor TFIIK complex  
    part_of transcription factor TFIIK complex  

    General protein information

    Preferred Names
    CDK-activating kinase assembly factor MAT1
    Names
    CDK7/cyclin-H assembly factor
    RING finger protein MAT1
    p35

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008612.2NP_032638.2  CDK-activating kinase assembly factor MAT1

      See identical proteins and their annotated locations for NP_032638.2

      Status: VALIDATED

      Source sequence(s)
      AK155859, AK157721
      Consensus CDS
      CCDS49087.1
      UniProtKB/Swiss-Prot
      P51949, Q14BS9, Q3TZP0, Q9D8A0, Q9D8D2
      Related
      ENSMUSP00000021523.7, ENSMUST00000021523.7
      Conserved Domains (2) summary
      TIGR00570
      Location:1308
      cdk7; CDK-activating kinase assembly factor MAT1
      cl17238
      Location:350
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      73158957..73320762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244008.4XP_011242310.1  CDK-activating kinase assembly factor MAT1 isoform X1

      See identical proteins and their annotated locations for XP_011242310.1

      Conserved Domains (1) summary
      TIGR00570
      Location:1187
      cdk7; CDK-activating kinase assembly factor MAT1
    2. XM_006515526.4XP_006515589.1  CDK-activating kinase assembly factor MAT1 isoform X1

      See identical proteins and their annotated locations for XP_006515589.1

      Conserved Domains (1) summary
      TIGR00570
      Location:1187
      cdk7; CDK-activating kinase assembly factor MAT1
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