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    Cbx7 chromobox 7 [ Mus musculus (house mouse) ]

    Gene ID: 52609, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Cbx7provided by MGI
    Official Full Name
    chromobox 7provided by MGI
    Primary source
    MGI:MGI:1196439
    See related
    Ensembl:ENSMUSG00000053411 AllianceGenome:MGI:1196439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D15Ertd417e; 1600014J01Rik
    Summary
    Enables chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 23.7), placenta adult (RPKM 17.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cbx7 in Genome Data Viewer
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79800005..79855344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79915804..79971143, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10856 Neighboring gene STARR-seq mESC enhancer starr_39199 Neighboring gene RIKEN cDNA D730005E14 gene Neighboring gene STARR-positive B cell enhancer ABC_E7391 Neighboring gene STARR-positive B cell enhancer ABC_E4141 Neighboring gene STARR-positive B cell enhancer ABC_E3147 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Neighboring gene STARR-seq mESC enhancer starr_39200 Neighboring gene STARR-seq mESC enhancer starr_39204 Neighboring gene STARR-positive B cell enhancer ABC_E7392 Neighboring gene STARR-positive B cell enhancer mm9_chr15:79765174-79765475 Neighboring gene STARR-positive B cell enhancer ABC_E9420 Neighboring gene VISTA enhancer mm570 Neighboring gene STARR-seq mESC enhancer starr_39213 Neighboring gene predicted gene, 53903 Neighboring gene microRNA 7213 Neighboring gene platelet derived growth factor, B polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effect of CBX7 deficiency on the socket healing after tooth extractions. Jiang F, et al. J Bone Miner Metab, 2019 Jul. PMID 30238429
    2. Polycomb chromobox (Cbx) 7 modulates activation-induced CD4+ T cell apoptosis. Li J, et al. Arch Biochem Biophys, 2014 Dec 15. PMID 25449062
    3. CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation. Forzati F, et al. Biol Open, 2014 Sep 4. PMID 25190058, Free PMC Article
    4. CBX7 deficiency plays a positive role in dentin and alveolar bone development. Zhou Z, et al. J Mol Histol, 2016 Aug. PMID 27271093
    5. Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. Wu HA, et al. J Biol Chem, 2013 Dec 20. PMID 24194518, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.
      Title: CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.
    2. Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
      Title: Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
    3. CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
      Title: CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
    4. Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway.
      Title: Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway.
    5. A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells.
      Title: A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells.
    6. Mass spectrometry analysis revealed several non-histone protein interactions between CBX7 and the H3K9 methyltransferases SETDB1, EHMT1, and EHMT2. These CBX7-binding proteins possess a trimethylated lysine peptide motif highly similar to the canonical CBX7 target H3K27me3.
      Title: CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions.
    7. Knockdown of CBX7 in either embryonic cortical neurons or adult dorsal root ganglion (DRG) neurons enhances their axon growth ability. Two important transcription factors GATA4 and SOX11 are functional downstream targets of CBX7 in controlling axon regeneration.
      Title: Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration.
    8. CBX7 deficiency has a positive effect on tooth extraction socket healing.
      Title: Effect of CBX7 deficiency on the socket healing after tooth extractions.
    9. Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin.
      Title: Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.
    10. these results of this study suggest that CBX7 deficiency plays a positive role in dentin and alveolar bone formation.
      Title: CBX7 deficiency plays a positive role in dentin and alveolar bone development.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sebaceous gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chromobox protein homolog 7
    Names
    chromobox homolog 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144811.3 → NP_659060.1  chromobox protein homolog 7

      See identical proteins and their annotated locations for NP_659060.1

      Status: VALIDATED

      Source sequence(s)
      AC113595, BC042657, BQ571764
      Consensus CDS
      CCDS37143.1
      UniProtKB/Swiss-Prot
      Q8VDS3
      Related
      ENSMUSP00000105245.3, ENSMUST00000109616.9
      Conserved Domains (1) summary
      pfam00385
      Location:13 → 60
      Chromo; Chromo (CHRromatin Organization MOdifier) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79800005..79855344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245690.3 → XP_011243992.1  chromobox protein homolog 7 isoform X2

      UniProtKB/TrEMBL
      A0A6M8AZW7
      Conserved Domains (2) summary
      pfam17218
      Location:188 → 219
      CBX7_C; CBX family C-terminal motif
      cl28914
      Location:15 → 41
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    2. XM_011245691.3 → XP_011243993.1  chromobox protein homolog 7 isoform X3

      See identical proteins and their annotated locations for XP_011243993.1

      Conserved Domains (1) summary
      pfam17218
      Location:155 → 186
      CBX7_C; CBX family C-terminal motif

    3. XM_006521148.4 → XP_006521211.1  chromobox protein homolog 7 isoform X5

      Conserved Domains (1) summary
      pfam17218
      Location:96 → 127
      CBX7_C; CBX family C-terminal motif

    4. XM_006521147.5 → XP_006521210.1  chromobox protein homolog 7 isoform X4

      Conserved Domains (2) summary
      cd18646
      Location:7 → 62
      CD_Cbx7; chromodomain of chromobox homolog 7
      pfam17218
      Location:150 → 181
      CBX7_C; CBX family C-terminal motif

    5. XM_006521144.5 → XP_006521207.1  chromobox protein homolog 7 isoform X1

      UniProtKB/TrEMBL
      A0A6M8AZW7, F8WHN2
      Related
      ENSMUSP00000086708.5, ENSMUST00000089293.11
      Conserved Domains (2) summary
      cd18646
      Location:7 → 62
      CD_Cbx7; chromodomain of chromobox homolog 7
      pfam17218
      Location:209 → 240
      CBX7_C; CBX family C-terminal motif

    6. XM_011245692.4 → XP_011243994.1  chromobox protein homolog 7 isoform X3

      See identical proteins and their annotated locations for XP_011243994.1

      Conserved Domains (1) summary
      pfam17218
      Location:155 → 186
      CBX7_C; CBX family C-terminal motif

    RNA

    1. XR_003951404.2 RNA Sequence

    2. XR_384025.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDS3.1 GenPept UniProtKB/Swiss-Prot:Q8VDS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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