Grid1 glutamate receptor, ionotropic, delta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grid1provided by MGI
Official Full Name: glutamate receptor, ionotropic, delta 1provided by MGI
Primary source: MGI:MGI:95812
See related: Ensembl:ENSMUSG00000041078 AllianceGenome:MGI:95812
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GluD1; GluRdelta1
Summary: Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including regulation of postsynapse organization; social behavior; and synaptic signaling via neuropeptide. Part of trans-synaptic protein complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including brain; genitourinary system; gut; liver and biliary system; and spinal cord. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 4.3), frontal lobe adult (RPKM 4.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 20.84 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (34541751..35305344)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (34820003..35583387)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain.
Title: Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain.
Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity.
Title: Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity.
Study found that glutamate delta-1 KO mice have higher preference for cocaine in conditioned place preference test and exhibit significantly more cocaine-induced structural plasticity and spine maturation compared to wildtype.
Title: Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.
GluD1 interacts with mGlu5, and loss of GluD1 impairs normal mGlu5 signaling potentially by dysregulating coupling to its effector.
Title: Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus.
Deletion of GluD1 leads to aberrant circuitry in prefrontal cortex and amygdala. Furthermore, these findings are in agreement with the human genetic studies suggesting a strong association of GRID1 gene with several neuropsychiatric disorders.
Title: Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors.
GluRdelta1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with pre-synaptic neurexins containing splice segment 4 through Cbln subtypes.
Title: Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.
The residues in the highly conserved SYTANLAAF region form the activation gate for GluRdelta1, since mutations in a set of closely arranged residues are found to generate spontaneously open channels.
Title: Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate δ1 receptor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Mit149 (e-PCR), detects polymorphism
- UniSTS:127259

D14Mit17 (e-PCR), detects polymorphism
- UniSTS:127281

G36389 (e-PCR)
- UniSTS:49990

Grid1 (e-PCR), detects polymorphism
- UniSTS:143253

UniSTS:143254 (e-PCR)
- UniSTS:143254

Grid1 (e-PCR), detects polymorphism
- UniSTS:143254

D14Mit54 (e-PCR), detects polymorphism
- UniSTS:127411

D14Mit79 (e-PCR), detects polymorphism
- UniSTS:127435

11.MMHAP61FLD2.seq (e-PCR)
- UniSTS:123084

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AMPA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic signaling via neuropeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of trans-synaptic protein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, delta-1

Names: gluR delta-1 subunit; glutamate receptor delta-1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008166.2 → NP_032192.2 glutamate receptor ionotropic, delta-1 precursor

Status: VALIDATED

Source sequence(s)

AC154730, AK138279, BM899969, DN176234

Consensus CDS

CCDS26944.1

UniProtKB/Swiss-Prot

Q3UUL5, Q61627

Related

ENSMUSP00000044009.6, ENSMUST00000043349.7

Conserved Domains (2) summary

cd06392
Location:25 → 423

PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family

cd13730
Location:436 → 806

PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

34541751..35305344

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244962.4 → XP_011243264.1 glutamate receptor ionotropic, delta-1 isoform X2

Conserved Domains (2) summary

cd13730
Location:436 → 806

PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily

cd06392
Location:25 → 425

PBP1_iGluR_delta_1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
XM_006518565.4 → XP_006518628.1 glutamate receptor ionotropic, delta-1 isoform X1

Conserved Domains (2) summary

cd13730
Location:341 → 711

PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:25 → 330

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_006518566.4 → XP_006518629.1 glutamate receptor ionotropic, delta-1 isoform X3

Conserved Domains (2) summary

cd13730
Location:225 → 595

PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:1 → 214

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily