Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts19provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 19provided by MGI
Primary source: MGI:MGI:2442875
See related: Ensembl:ENSMUSG00000053441 AllianceGenome:MGI:2442875
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4831407I23Rik; D230034E10Rik
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is predominantly expressed in the ovary with lower levels of expression observed in kidney, heart, skeletal muscle, lung and testis. The encoded preproprotein undergoes proteolytic processing to generate an active protease. [provided by RefSeq, Jul 2016]
Expression: Biased expression in ovary adult (RPKM 2.6), limb E14.5 (RPKM 2.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 D3; 18 33.78 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (58967819..59186754)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (58835992..59053682)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation.
Title: Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation.
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.
Title: Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adamts19 (e-PCR), detects polymorphism
- UniSTS:464652

Adamts19 (e-PCR), detects polymorphism
- UniSTS:532647

Adamts19 (e-PCR), detects polymorphism
- UniSTS:256996

AU015154 (e-PCR)
- UniSTS:209385

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitral valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in tricuspid valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 19

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175506.4 → NP_780715.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 preproprotein

See identical proteins and their annotated locations for NP_780715.1

Status: REVIEWED

Source sequence(s)

AC132242, AY135183, CJ092717

Consensus CDS

CCDS29266.1

UniProtKB/Swiss-Prot

P59509

UniProtKB/TrEMBL

B2RWW7

Related

ENSMUSP00000050535.6, ENSMUST00000052907.7

Conserved Domains (6) summary

smart00209
Location:1091 → 1146

TSP1; Thrombospondin type 1 repeats

cd04273
Location:328 → 545

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:330 → 545

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:158 → 275

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:793 → 903

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1174 → 1199

PLAC; PLAC (protease and lacunin) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

58967819..59186754

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161138.1 → XP_036017031.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X3

Conserved Domains (2) summary

pfam05986
Location:289 → 399

ADAM_spacer1; ADAM-TS Spacer 1

pfam19030
Location:614 → 666

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_006525919.5 → XP_006525982.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X1

UniProtKB/TrEMBL

B2RWW7

Conserved Domains (5) summary

smart00209
Location:1115 → 1170

TSP1; Thrombospondin type 1 repeats

cd04273
Location:328 → 545

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:161 → 276

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:793 → 903

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:562 → 629

ADAM_CR_2; ADAM cysteine-rich domain
XM_036161139.1 → XP_036017032.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X4

Conserved Domains (2) summary

pfam05986
Location:283 → 393

ADAM_spacer1; ADAM-TS Spacer 1

pfam19030
Location:608 → 660

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_030250458.2 → XP_030106318.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X6

Conserved Domains (3) summary

cd04273
Location:328 → 545

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:161 → 276

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:562 → 621

ADAM_CR_2; ADAM cysteine-rich domain
XM_011246927.4 → XP_011245229.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X5

Conserved Domains (3) summary

cd04273
Location:328 → 545

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:161 → 276

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:562 → 587

ADAM_CR_2; ADAM cysteine-rich domain
XM_011246926.3 → XP_011245228.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X2

Conserved Domains (4) summary

smart00209
Location:681 → 736

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:359 → 469

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:128 → 195

ADAM_CR_2; ADAM cysteine-rich domain

cl00064
Location:9 → 111

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...