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    Armcx3 armadillo repeat containing, X-linked 3 [ Mus musculus (house mouse) ]

    Gene ID: 71703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Armcx3provided by MGI
    Official Full Name
    armadillo repeat containing, X-linked 3provided by MGI
    Primary source
    MGI:MGI:1918953
    See related
    Ensembl:ENSMUSG00000049047 AllianceGenome:MGI:1918953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALEX3; 1200004E24Rik
    Summary
    Acts upstream of or within several processes, including axonal transport of mitochondrion; mitochondrion organization; and positive regulation of transcription by RNA polymerase II. Located in cytosol; mitochondrial outer membrane; and nucleus. Is expressed in several structures, including central nervous system; hindlimb bud; jaw bone; mesenchyme derived from neural crest; and testis mesenchyme. Orthologous to human ARMCX3 (armadillo repeat containing X-linked 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 12.0), limb E14.5 (RPKM 11.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Armcx3 in Genome Data Viewer
    Location:
    X E3; X 56.25 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133657301..133662206)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134756552..134761457)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 7, pseudogene Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene microRNA 7093 Neighboring gene STARR-seq mESC enhancer starr_47969 Neighboring gene armadillo repeat containing, X-linked 2 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity. Gavaldà-Navarro A, et al. Int J Obes (Lond), 2022 Sep. PMID 35705702
    2. ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity. Mirra S, et al. Cancers (Basel), 2021 Mar 5. PMID 33807672, Free PMC Article
    3. DNA microarray analysis of region-specific gene expression in the mouse epididymis. Hsia N, et al. Biol Reprod, 2004 Feb. PMID 14561649
    4. Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway. Du J, et al. Tumour Biol, 2017 Jul. PMID 28705116
    5. The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. Mou Z, et al. J Biol Chem, 2009 May 15. PMID 19304657, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mammalian-specific Alex3/Galphaq protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.
      Title: A mammalian-specific Alex3/Gα(q) protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.
    2. The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity.
      Title: The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity.
    3. Sox10 is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3
      Title: The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonal transport of mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    armadillo repeat-containing X-linked protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358520.1 → NP_001345449.1  armadillo repeat-containing X-linked protein 3

      Status: VALIDATED

      Source sequence(s)
      AL772348, CX563636
      Consensus CDS
      CCDS30400.1
      UniProtKB/Swiss-Prot
      A2AKS4, Q8BHS6, Q91VP8, Q9DC32
      Related
      ENSMUSP00000084093.5, ENSMUST00000086880.11
      Conserved Domains (2) summary
      sd00043
      Location:156 → 190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112 → 363
      Arm_2; Armadillo-like

    2. NM_001358521.1 → NP_001345450.1  armadillo repeat-containing X-linked protein 3

      Status: VALIDATED

      Source sequence(s)
      AL772348, BY310567
      Consensus CDS
      CCDS30400.1
      UniProtKB/Swiss-Prot
      A2AKS4, Q8BHS6, Q91VP8, Q9DC32
      Related
      ENSMUSP00000084097.5, ENSMUST00000086884.5
      Conserved Domains (2) summary
      sd00043
      Location:156 → 190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112 → 363
      Arm_2; Armadillo-like

    3. NM_027870.4 → NP_082146.2  armadillo repeat-containing X-linked protein 3

      See identical proteins and their annotated locations for NP_082146.2

      Status: VALIDATED

      Source sequence(s)
      AL772348, BU505969, CJ071609
      Consensus CDS
      CCDS30400.1
      UniProtKB/Swiss-Prot
      A2AKS4, Q8BHS6, Q91VP8, Q9DC32
      Related
      ENSMUSP00000080518.4, ENSMUST00000081834.10
      Conserved Domains (2) summary
      sd00043
      Location:156 → 190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112 → 363
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133657301..133662206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318626.2 → XP_017174115.1  armadillo repeat-containing X-linked protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A2AKS4, Q8BHS6, Q91VP8, Q9DC32
      Conserved Domains (2) summary
      sd00043
      Location:156 → 190
      ARM; armadillo repeat [structural motif]
      pfam04826
      Location:112 → 363
      Arm_2; Armadillo-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHS6.1 GenPept UniProtKB/Swiss-Prot:Q8BHS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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