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    PCGF3 polycomb group ring finger 3 [ Homo sapiens (human) ]

    Gene ID: 10336, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PCGF3provided by HGNC
    Official Full Name
    polycomb group ring finger 3provided by HGNC
    Primary source
    HGNC:HGNC:10066
    See related
    Ensembl:ENSG00000185619 MIM:617543; AllianceGenome:HGNC:10066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF3; DONG1; RNF3A
    Summary
    The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 24.1), endometrium (RPKM 13.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PCGF3 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (705832..770089)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (705458..767880)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (699621..763877)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:668197-668954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:674515-675154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:680358-681306 Neighboring gene uncharacterized LOC124900643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:682255-683203 Neighboring gene solute carrier family 49 member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:683204-684151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:686336-686923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:686924-687510 Neighboring gene myosin light chain 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:688618-689118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:694583-695083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:697641-698368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:699409-700394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:700395-701379 Neighboring gene uncharacterized LOC124900172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:720375-720890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:720891-721405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:725234-725734 Neighboring gene uncharacterized LOC107986246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15107 Neighboring gene uncharacterized LOC124900644 Neighboring gene chloride intracellular channel protein 6-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:759135-759682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21134 Neighboring gene PCGF3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:762535-763476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:774752-775469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:775470-776186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:776187-776904 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:778899-779770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:781743-782244 Neighboring gene uncharacterized LOC105374339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:782245-782744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:783251-783750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:784983-785792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:793259-793758 Neighboring gene complexin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:823745-824262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:824263-824778 Neighboring gene uncharacterized LOC105374340

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway. Hu Y, et al. Exp Cell Res, 2021 Mar 15. PMID 33485844
    2. KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. Wong SJ, et al. Structure, 2016 Oct 4. PMID 27568929, Free PMC Article
    3. PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study. Mu G, et al. Pharmacogenomics, 2020 Jun. PMID 32397904
    4. Extratelomeric Binding of the Telomere Binding Protein TRF2 at the PCGF3 Promoter Is G-Quadruplex Motif-Dependent. Purohit G, et al. Biochemistry, 2018 Apr 24. PMID 29589913
    5. Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells. Zhu Y, et al. Stem Cell Reports, 2022 May 10. PMID 35364009, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
      Title: PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
    2. PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study.
      Title: PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study.
    3. We demonstrate that promoter binding by TRF2 mediates PCGF3 promoter activity, and both the N-terminal and C-terminal domains of TRF2 are necessary for promoter activity.
      Title: Extratelomeric Binding of the Telomere Binding Protein TRF2 at the PCGF3 Promoter Is G-Quadruplex Motif-Dependent.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36550, FLJ43813, MGC40413, MGC129615, DKFZp686D20235

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone H2AK119 ubiquitin ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in random inactivation of X chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with X chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polycomb group RING finger protein 3
    Names
    RING finger protein 3A
    ring finger protein 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317836.3 → NP_001304765.1  polycomb group RING finger protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-7 all encode the same isoform (a).
      Source sequence(s)
      AC107464, AC139887
      Consensus CDS
      CCDS3339.2
      UniProtKB/Swiss-Prot
      D3DVN1, O15262, Q3KNV8
      UniProtKB/TrEMBL
      B3KQ06
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:154 → 236
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    2. NM_001395245.1 → NP_001382174.1  polycomb group RING finger protein 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC107464, AC139887
      Consensus CDS
      CCDS3339.2
      UniProtKB/Swiss-Prot
      D3DVN1, O15262, Q3KNV8
      UniProtKB/TrEMBL
      B3KQ06
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:154 → 236
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    3. NM_001395246.1 → NP_001382175.1  polycomb group RING finger protein 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC107464, AC139887
      Consensus CDS
      CCDS3339.2
      UniProtKB/Swiss-Prot
      D3DVN1, O15262, Q3KNV8
      UniProtKB/TrEMBL
      B3KQ06
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:154 → 236
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    4. NM_001395247.1 → NP_001382176.1  polycomb group RING finger protein 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC107464, AC139887
      Consensus CDS
      CCDS3339.2
      UniProtKB/Swiss-Prot
      D3DVN1, O15262, Q3KNV8
      UniProtKB/TrEMBL
      B3KQ06
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:154 → 236
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    5. NM_001395248.1 → NP_001382177.1  polycomb group RING finger protein 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC107464, AC139887
      Consensus CDS
      CCDS3339.2
      UniProtKB/Swiss-Prot
      D3DVN1, O15262, Q3KNV8
      UniProtKB/TrEMBL
      B3KQ06
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:154 → 236
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    6. NM_001395249.1 → NP_001382178.1  polycomb group RING finger protein 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC107464, AC139887
      Consensus CDS
      CCDS3339.2
      UniProtKB/Swiss-Prot
      D3DVN1, O15262, Q3KNV8
      UniProtKB/TrEMBL
      B3KQ06
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:154 → 236
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    7. NM_001395250.1 → NP_001382179.1  polycomb group RING finger protein 3 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC107464, AC139887
      UniProtKB/TrEMBL
      B3KQ06, B3KWT8
      Conserved Domains (2) summary
      cd17083
      Location:120 → 202
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cl17238
      Location:2 → 26
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    8. NM_001395251.1 → NP_001382180.1  polycomb group RING finger protein 3 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC107464, AC139887
      UniProtKB/TrEMBL
      B3KQ06, B3KWT8
      Conserved Domains (2) summary
      cd17083
      Location:120 → 202
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cl17238
      Location:2 → 26
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    9. NM_006315.7 → NP_006306.2  polycomb group RING finger protein 3 isoform a

      See identical proteins and their annotated locations for NP_006306.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1-7 all encode the same isoform (a).
      Source sequence(s)
      AC107464, AC139887
      Consensus CDS
      CCDS3339.2
      UniProtKB/Swiss-Prot
      D3DVN1, O15262, Q3KNV8
      UniProtKB/TrEMBL
      B3KQ06
      Related
      ENSP00000354724.5, ENST00000362003.10
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:154 → 236
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      705832..770089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449500.1 → XP_047305456.1  polycomb group RING finger protein 3 isoform X1

      UniProtKB/TrEMBL
      B3KQ06, B3KWT8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      705458..767880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348726.1 → XP_054204701.1  polycomb group RING finger protein 3 isoform X1

      UniProtKB/TrEMBL
      B3KQ06, B3KWT8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KNV8.1 GenPept UniProtKB/Swiss-Prot:Q3KNV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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