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    UBC8 E2 ubiquitin-conjugating protein UBC8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856704, updated on 9-Dec-2024

    Summary

    Official Symbol
    UBC8
    Official Full Name
    E2 ubiquitin-conjugating protein UBC8
    Primary source
    SGD:S000000738
    Locus tag
    YEL012W
    See related
    AllianceGenome:SGD:S000000738; FungiDB:YEL012W; VEuPathDB:YEL012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GID3
    Summary
    Enables ubiquitin-protein transferase activity. Involved in mitochondrial outer membrane translocase complex assembly; negative regulation of gluconeogenesis; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See UBC8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_001137.3 (131772..132551)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene protein anchor VAC8 Neighboring gene tRNA-Gln Neighboring gene 1,4-alpha-glucan branching enzyme Neighboring gene tRNA-Lys

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein binding PubMed 
    enables transferase activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin-protein transferase activity PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in mitochondrion  
    is_active_in nucleus  

    General protein information

    Preferred Names
    E2 ubiquitin-conjugating protein UBC8
    NP_010904.2
    • Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      131772..132551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178827.1 → NP_010904.2  TPA: E2 ubiquitin-conjugating protein UBC8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010904.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLN7, P28263
      UniProtKB/TrEMBL
      A6ZQT7, B3LS04, C8Z6Y8
      Conserved Domains (1) summary
      COG5078
      Location:2 → 149
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
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