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    LSR lipolysis stimulated lipoprotein receptor [ Homo sapiens (human) ]

    Gene ID: 51599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSRprovided by HGNC
    Official Full Name
    lipolysis stimulated lipoprotein receptorprovided by HGNC
    Primary source
    HGNC:HGNC:29572
    See related
    Ensembl:ENSG00000105699 MIM:616582; AllianceGenome:HGNC:29572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILDR3; LISCH7
    Summary
    Predicted to be involved in several processes, including establishment of skin barrier; protein localization to tricellular tight junction; and tricellular tight junction assembly. Located in plasma membrane and tight junction. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach (RPKM 52.0), colon (RPKM 51.5) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LSR in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35249002..35267964)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37793654..37812636)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35739905..35758867)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187 member B Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14461 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35738792-35739594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35739595-35740396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35748323-35748823 Neighboring gene uncharacterized LOC105372380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35753027-35753725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35761221-35761960 Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene HNF4 motif-containing MPRA enhancer 344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35773293-35773802 Neighboring gene hepcidin antimicrobial peptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer. Shimada H, et al. Sci Rep, 2017 Jan 10. PMID 28071680, Free PMC Article
    2. Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer. Tang X, et al. J Cell Biochem, 2020 Nov. PMID 32048750
    3. Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells. Konno T, et al. J Histochem Cytochem, 2020 Jan. PMID 31662022, Free PMC Article
    4. Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line. Kyuno T, et al. Histochem Cell Biol, 2020 Jan. PMID 31650247
    5. LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway. Takahashi Y, et al. Biochem Biophys Res Commun, 2021 Jan 22. PMID 33388415

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-beta-dependent cell metabolism in human lung adenocarcinoma A549 cells.
      Title: Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.
    2. LSR Promotes Cell Proliferation and Invasion in Lung Cancer.
      Title: LSR Promotes Cell Proliferation and Invasion in Lung Cancer.
    3. Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.
      Title: Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.
    4. Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer.
      Title: Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer.
    5. LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.
      Title: LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.
    6. Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.
      Title: Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.
    7. HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.
      Title: HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.
    8. ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.
      Title: ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.
    9. Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.
      Title: Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.
    10. In pancreatic cancer, LSR contributes to the epithelial barrier and malignancy via growth factors and may be a potential targeting molecule in the therapy.
      Title: Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC10659, MGC48312, MGC48503

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in epithelial structure maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of blood-brain barrier IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of blood-brain barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of skin barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in liver development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within maintenance of blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization to tricellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tricellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricellular tight junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    part_of chylomicron IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in tricellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in tricellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipolysis-stimulated lipoprotein receptor
    Names
    LISCH protein
    angulin-1
    immunoglobulin-like domain containing receptor 3
    lipolysis-stimulated remnant
    liver-specific bHLH-Zip transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260489.2 → NP_001247418.2  lipolysis-stimulated lipoprotein receptor isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC002128, AD000684
      Consensus CDS
      CCDS59376.2
      UniProtKB/TrEMBL
      A0A8Z5DL71, Q9BWS2
      Related
      ENSP00000472569.2, ENST00000602122.5
      Conserved Domains (1) summary
      PHA03307
      Location:243 → 538
      PHA03307; transcriptional regulator ICP4; Provisional

    2. NM_001260490.2 → NP_001247419.2  lipolysis-stimulated lipoprotein receptor isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC002128, AD000684
      Consensus CDS
      CCDS92587.1
      UniProtKB/TrEMBL
      Q9BWS2
      Related
      ENSP00000394479.1, ENST00000427250.5
      Conserved Domains (2) summary
      PHA03307
      Location:154 → 450
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR01622
      Location:371 → 485
      SF-CC1; splicing factor, CC1-like family

    3. NM_001385215.1 → NP_001372144.1  lipolysis-stimulated lipoprotein receptor isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC002128, AD000684
      UniProtKB/TrEMBL
      Q9BWS2
      Conserved Domains (1) summary
      PHA03307
      Location:194 → 489
      PHA03307; transcriptional regulator ICP4; Provisional

    4. NM_015925.7 → NP_057009.4  lipolysis-stimulated lipoprotein receptor isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC002128, AD000684
      Consensus CDS
      CCDS12449.2
      UniProtKB/TrEMBL
      A0A8Z5ABK9, Q9BWS2
      Related
      ENSP00000346976.3, ENST00000354900.7
      Conserved Domains (1) summary
      PHA03307
      Location:243 → 539
      PHA03307; transcriptional regulator ICP4; Provisional

    5. NM_205834.4 → NP_991403.2  lipolysis-stimulated lipoprotein receptor isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AC002128, AD000684
      Consensus CDS
      CCDS12450.2
      UniProtKB/TrEMBL
      Q9BWS2, S4R3V8
      Related
      ENSP00000474797.2, ENST00000605618.6
      Conserved Domains (1) summary
      PHA03307
      Location:262 → 558
      PHA03307; transcriptional regulator ICP4; Provisional

    6. NM_205835.4 → NP_991404.2  lipolysis-stimulated lipoprotein receptor isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC002128, AD000684
      Consensus CDS
      CCDS12451.2
      UniProtKB/TrEMBL
      A0A8Z5AA41, Q9BWS2
      Related
      ENSP00000354034.3, ENST00000360798.7
      Conserved Domains (1) summary
      PHA03307
      Location:194 → 490
      PHA03307; transcriptional regulator ICP4; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35249002..35267964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258980.3 → XP_005259037.2  lipolysis-stimulated lipoprotein receptor isoform X1

      UniProtKB/TrEMBL
      Q9BWS2
      Related
      ENSP00000262627.3, ENST00000347609.8

    2. XM_011527026.3 → XP_011525328.2  lipolysis-stimulated lipoprotein receptor isoform X2

      UniProtKB/TrEMBL
      Q9BWS2

    3. XM_047438920.1 → XP_047294876.1  lipolysis-stimulated lipoprotein receptor isoform X3

      UniProtKB/TrEMBL
      Q9BWS2

    4. XM_047438921.1 → XP_047294877.1  lipolysis-stimulated lipoprotein receptor isoform X4

      UniProtKB/TrEMBL
      Q9BWS2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      37793654..37812636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321193.1 → XP_054177168.1  lipolysis-stimulated lipoprotein receptor isoform X1

      UniProtKB/TrEMBL
      Q9BWS2

    2. XM_054321194.1 → XP_054177169.1  lipolysis-stimulated lipoprotein receptor isoform X2

      UniProtKB/TrEMBL
      Q9BWS2

    3. XM_054321195.1 → XP_054177170.1  lipolysis-stimulated lipoprotein receptor isoform X3

      UniProtKB/TrEMBL
      Q9BWS2

    4. XM_054321196.1 → XP_054177171.1  lipolysis-stimulated lipoprotein receptor isoform X4

      UniProtKB/TrEMBL
      Q9BWS2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86X29.4 GenPept UniProtKB/Swiss-Prot:Q86X29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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